DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx32

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001123511.1	Gene:	Dhx32 / 361667	RGDID:	1311740	Length:	751	Species:	Rattus norvegicus

Alignment Length:	864	Identity:	189/864 - (21%)
Similarity:	339/864 - (39%)	Gaps:	186/864 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 EKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFRE 382
            |..:|....|.|.|:..:......:.|..|....:.:||    |.:..|.....:.|.:.|:.||
  Rat     7 EMDEEELEHPNASPEKRYFPESLDSSDGDEEGVLACEDL----ELNPFDGLPYSSRYYKLLKERE 67

  Fly   383 KLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAI 447
            :|||...:...:.::..|.||::.|::.|||::|:.|:.. :|..|....:..:..||..:.:|:
  Rat    68 ELPIWKEKYSFMESLLQNQVVLVSGDSKCGKSSQVPQWCA-EYCLSIHYQHGGVICTQVHKQTAV 131

  Fly   448 SVAERVARERCEQLGDTVGYSVRFESVFPRPYGAIL-FCTVGVLLRKLEA----GLRGVSHIIVD 507
            .:|.|||.|....:|..|||.:.||:.....  .|| :||..:|.|::.:    |..||  ||:|
  Rat   132 QLALRVADEMDVNIGHEVGYVIPFENCCTTE--TILRYCTDDMLQREMMSNPFLGSYGV--IILD 192

  Fly   508 EIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLE 572
            ::|||.:.:|.||.:|:|::...|:|.:|:..:....::.|.|:|..|:|||..: .||:..:|.
  Rat   193 DVHERSLATDVLLGLLKDVLLARPELKLIINCSPFLISRLSSYYGNVPLLEVRNK-HPVEVVYLS 256

  Fly   573 DIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSF 637
                                        ...||                              .|
  Rat   257 ----------------------------GAQKD------------------------------PF 263

  Fly   638 ELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFL--QNTNIFGDTSQYQILPCHSQIPRDEQR 700
            |.:..|:..|......|.::|||.....|....:.:  :.:|:..|..:..::|.:.:    |:.
  Rat   264 ESVVRLIFEIHRSGEQGDVVVFLACEQDIEKTYEIVCQEGSNLNPDVGELVVIPLYPK----EKC 324

  Fly   701 KVFEPVPE-------GVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWAS 758
            .:|.||.|       ...:::|:|:..|:.|....:.||||:...|.:::.......|......|
  Rat   325 SLFRPVDETEKRCQASQRRVVLTTSCGESLIWSHTVRFVIDVGLERRQVYNPRIRANSLVLQPIS 389

  Fly   759 KTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTP----EMFRTPLHEMALTIKLLRLGSIHH 819
            ::..|.||...|....|..|.|.:.   :....::.|    ||....|..|.|.:|.:.:..:..
  Rat   390 QSQAEIRKQLLGSSPSGKLFCLYTE---EFASKDMRPLKPAEMQEANLTSMVLFMKRVDIAGLGR 451

  Fly   820 --FLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD 882
              |:::    |..:::::|...|..:..||.:..|:..|.:::..|::|:|.|.::....|.|.|
  Rat   452 CDFMNR----PAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVD 512

  Fly   883 LM---AIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKC--------SDHVAMIVASQMWRRE- 935
            .|   |.|.:..|.|..|           .|....:...|        .||..:|.....::..
  Rat   513 EMLTIAAMVTAPSCFLHV-----------PHGAEEAAVTCWKTFLHPEGDHFTLINIYNAYQDTV 566

  Fly   936 -KQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP--EECMISHEVDERIDGDDPVL 997
             ....||....:|....|..|.:.:....:.:||:::::...|  |....|.|     :|    |
  Rat   567 LNSANEHCVETWCHNCFLSCSALRMADVIRAELLEIIKRIELPYAEPAFGSQE-----NG----L 622

  Fly   998 DVSLALLCLGLYPNIC--VHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRA 1060
            ::..|||. |.:..|.  |......::.|..:.|.||.    .|:.|:|...|
  Rat   623 NIKKALLS-GYFMQIARDVDGSGNYLMLTHKQVAQLHP----LSSYAITKKMP------------ 670

  Fly  1061 VSCKQLSMVSPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKI---------------GA 1110
                        :.:||  .:..::.||.:||.:    .:.|||..::               ..
  Rat   671 ------------EWVLF--HQFSISENNYIRVTS----AVSPELFMQLVPQYYFSNLPPSESKDI 717

  Fly  1111 LKPALEDLITVACDNPSDI 1129
            |:.|...|.|.|.|...|:
  Rat   718 LQQASGHLPTTAMDKDQDV 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	57/180 (32%)
		DEXDc	402..542	CDD:238005	47/144 (33%)
		ATP-synt_B	<584..644	CDD:304375	4/59 (7%)
		Helicase_C	643..772	CDD:278689	30/137 (22%)
		HA2	842..926	CDD:214852	21/94 (22%)
		OB_NTP_bind	974..1078	CDD:285018	21/107 (20%)
Dhx32	NP_001123511.1	HrpA	19..687	CDD:224557	173/797 (22%)
		DEXDc	86..202	CDD:238005	39/120 (33%)
		HA2	472..556	CDD:214852	21/94 (22%)
		OB_NTP_bind	597..704	CDD:285018	31/150 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900