DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and l(2)37Cb

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	1022	Identity:	264/1022 - (25%)
Similarity:	422/1022 - (41%)	Gaps:	209/1022 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 GSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWT 166
            |..:::......||.:...|....|.    |...|.....|::::.|.......|   :..|...
  Fly     3 GKNRKRTASSSSSGEEPDSEEESRLK----DLQERDEFASRLKKRDDDRTRNVVD---STGGRRA 60

  Fly   167 IENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSC 231
            ||.|.:||.:..:     |..|..|    |.|  |.....|:          |...:.|.|....
  Fly    61 IEEATKRLKLEHE-----DRDKIVP----HLR--LQSRRQYL----------EKRKDDKVAELEA 104

  Fly   232 ALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIEL 296
            .:.....||..:|:      .|::|:|:      :....|:|...|..|..:|..:...|:..:|
  Fly   105 DILDDEYLFDESVL------TKREKEER------EYKKQLLNIAKEHEKARELERIQRYNMPQDL 157

  Fly   297 DGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDD------ 355
            ........|.:...:......:|:.|:..:  |..:.::....|...:|.||.   :||
  Fly   158 KKGERSEYVEVDEFEKQPNSEQKKWEAEQL--ASARFHFGAKDAKAEEEYELL---LDDQIDFIQ 217

  Fly   356 -LSMDYERSLRDRRQ---NDNEYRQFL--EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKT 414
             |::|..|.....||   .:.|.::..  |.|..||:...:.:::.|:.::.|:||.|.||.|||
  Fly   218 ALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKT 282

  Fly   415 TQIAQYILDDYICSGQGGYAN----IYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVF 475
            ||:.||::       :.|:..    |..|||||::|:|||.|||.|...:||:.||||:|||..
  Fly   283 TQVPQYLV-------EAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDC- 339

  Fly   476 PRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILM 538
            ......:.:.|.|.|.|:.  |..|...|.:|:||.|||.:::|.|..:::|:....|:|.:::.
  Fly   340 TSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLIS 404

  Fly   539 SATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSED 603
            |||:|..|||.:|...|:..:|||.:||..|:.:        .|.|:
  Fly   405 SATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTK--------APEAD------------------ 443

  Fly   604 KDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIP-GAILVFLPGWNLIF 667
                   |...|                       .:..|.:|...   | |.|||||.|.:.|.
  Fly   444 -------YIDAC-----------------------CVSVLQIHATQ---PLGDILVFLTGQDEIE 475

  Fly   668 ALMKFLQN--TNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIV 730
            ...:.|.:  ..:.....:..::|.::.:|.|.|.|:|||.|....|:||:|||||||:|||:|:
  Fly   476 TCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNII 540

  Fly   731 FVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLT 794
            :|||...|:...|.|...:.|...|..||.:..||.|||||..||.||.|.:...:: .||||..
  Fly   541 YVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTV 605

  Fly   795 PEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLL 859
            ||:.|..|....|.:|.|.:..:.||  ..|:|||.:.::.|...|..:..|:.:.|||.|||.:
  Fly   606 PEIQRINLGNAVLMLKALGINDLIHF--DFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRM 668

  Fly   860 ARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVF--------SLDIGQRRLANHQKALSG 916
            |..|::|.:|||::....:.|::.|..:|:..|..|.:|        ..|..::.. ||..
  Fly   669 AEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNF-NHMH---- 728

  Fly   917 TKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECM 981
               .||::::.....|..     .....::|....:|..:|....|.::||:.|:|:.
  Fly   729 ---GDHLSLLQVYNQWAE-----TDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRV------- 778

  Fly   982 ISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTT-------------------ESK 1027
               |:|              .:.||....|:      ||..|.                   .::
  Fly   779 ---EID--------------MVSCLPETVNV------RKAATAGYFYHVARLSKGGHYKTIKHNQ 820

  Fly  1028 AALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAV---SCKQLSMVSP 1071
            ..::|..|.....|.....|...||..|...|.|   ..|.|..|:|
  Fly   821 TVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAP 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	13/69 (19%)
		DEXDc	393..569	CDD:214692	70/181 (39%)
		DEXDc	402..542	CDD:238005	57/145 (39%)
		ATP-synt_B	<584..644	CDD:304375	3/59 (5%)
		Helicase_C	643..772	CDD:278689	51/131 (39%)
		HA2	842..926	CDD:214852	24/91 (26%)
		OB_NTP_bind	974..1078	CDD:285018	21/120 (18%)
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	213/756 (28%)
		DEXDc	269..408	CDD:238005	57/146 (39%)
		HELICc	491..581	CDD:197757	38/89 (43%)
		HA2	651..735	CDD:214852	24/91 (26%)
		OB_NTP_bind	770..869	CDD:285018	25/128 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840