DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and CG4901

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	206/721 - (28%)
Similarity:	332/721 - (46%)	Gaps:	126/721 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 RQFLEFREK-LPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN--- 435
            |..:|.::| ||:...|..||..:..|..|:|...||.||||||.|::|       ..|||.
  Fly    58 RTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLL-------LAGYAKNGM 115

  Fly   436 IYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK--LEAGL 498
            |.:|||||::||:||.|||:|....:||||||:||||.|..|. ..|.|.|.|||||:  .:..|
  Fly   116 IGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRA-TKIRFLTDGVLLRESIKDRLL 179

  Fly   499 RGVSHIIVDEIHERDVNSDFLLVILRD-----MVDTYPDLHVILMSATIDTTKFSKYFGICPVLE 558
            ...|.||:||.|||.||:|.|..|::|     ......:|.|::.|||:|...|..||. |..:.
  Fly   180 LKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-CKGMY 243

  Fly   559 VPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKT 623
            :.||.:||:                                :...|:|.|...:.|.
  Fly   244 LEGRTYPVR--------------------------------VMHTKEEHEDYIHTVL-------- 268

  Fly   624 RNAMAMLSESDVSFELLEALLMHI---KSKNIPGAILVFLPGWNLIFAL---MKFLQNTNIFGDT 682
                              ..|.||   ..||  ..:|:||.|...|.:|   ::.|...:..| |
  Fly   269 ------------------VTLFHIHRTTPKN--HDVLIFLTGQEEIESLAQQIRQLAKIDTTG-T 312

  Fly   683 SQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHN 747
            :..::...::|:.:.:|.:.|.|.|..|.|:||:||||||||||..|..|||....:.|.|.:.:
  Fly   313 TDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVD 377

  Fly   748 NLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLL 812
            .|....:|..||....||.|||||...|.|:...::|...:..|...||:.||  :..::.::||
  Fly   378 GLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRT--NPTSMVLQLL 440

  Fly   813 RLG-SIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDE--LTPLGRLLARLPIEPRLGKMMVL 874
            .|. ..::|  ..|:||..|.:..|...|..:..:...|:  :|||||.:.:.|::|:..|:::.
  Fly   441 ALDIDCNNF--DFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLT 503

  Fly   875 GAVFGC-ADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMI-VASQMWRREKQ 937
            .:.||| .:::::::..||  ..||..:..:..:|....|...:|..||:.:: |.:...:.||.
  Fly   504 ASSFGCMEEILSLVSVLSS--DHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKP 566

  Fly   938 RGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLA 1002
            :      .:|....|.:.::....:.::||.:            ||..:...::..|   |:.:.
  Fly   567 K------MWCHDNYLNLRSLTYARNVRRQLRE------------ISEHLHLALNSSD---DIEML 610

  Fly  1003 LLCL--GLYPNICVHKEKRKVLTTESK-AALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCK 1064
            ..|:  |.:.||.|.:.....:|.... .:.:|.:||    |...:...:.:|.|.::|.....:
  Fly   611 KKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSV----LHGKYKPSYILFTEIVQTEQTFLR 671

  Fly  1065 QLSMVS 1070
            |::.:|
  Fly   672 QVTEIS 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	81/185 (44%)
		DEXDc	402..542	CDD:238005	68/149 (46%)
		ATP-synt_B	<584..644	CDD:304375	4/59 (7%)
		Helicase_C	643..772	CDD:278689	49/134 (37%)
		HA2	842..926	CDD:214852	21/86 (24%)
		OB_NTP_bind	974..1078	CDD:285018	19/100 (19%)
CG4901	NP_001334733.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840