DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and dhx16

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	645	Identity:	199/645 - (30%)
Similarity:	317/645 - (49%)	Gaps:	88/645 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 IDEGELATTSIDDLSM----DYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVV 403
            ::|.|:.|.....::|    ..:.|..:..|.:.:.:...|.|..|||...|.::|.||.|:.::
Zfish   367 LEEEEMITFVSTAITMKGTLSEKESEPELSQAEKQKQSIQEVRRSLPIFPYREDLLAAIGDHQIL 431

  Fly   404 IIRGNTGCGKTTQIAQYILDDYICSGQGGYA----NIYVTQPRRISAISVAERVARERCEQLGDT 464
            :|.|.||.||||||.||:|::       ||.    .|..|||||::|:|||.|||:|...:||:.
Zfish   432 VIEGETGSGKTTQIPQYLLEE-------GYTKGGMKIGCTQPRRVAAMSVAARVAQEMSVKLGNE 489

  Fly   465 VGYSVRFESVFPRPYGAIL-FCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDM 526
            ||||:|||.....  ..|| :.|.|:|||:.  |..|...|.||:||.|||.:::|.|..:::|:
Zfish   490 VGYSIRFEDCTSE--RTILKYMTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILFGLIKDI 552

  Fly   527 VDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRK 591
            ....|||.|::.|||:||.:||.:|...||..:|||.|||..::.:        .|.|:
Zfish   553 ARFRPDLKVLVASATLDTERFSSFFDDAPVFRIPGRRFPVDIYYTK--------APEAD------ 603

  Fly   592 EVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAI 656
                               |.:.|                       ::..|.:|:...  ||.:
Zfish   604 -------------------YLEAC-----------------------VVSVLQIHVTQS--PGDV 624

  Fly   657 LVFLPGWNLIFALMKFLQN--TNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            ||||.|...|.|..:.||.  ..:....|:..:||.::.:|.|.|.|:|.|.|.|..|::::|||
Zfish   625 LVFLTGQEEIEACCELLQERCRRLGSKISELLVLPIYANLPSDMQAKIFNPTPPGARKVVVATNI 689

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            ||||:|||.|::|||....:.|.:.:...:.|......|:.:..||.||||||..|.||.|.:..
Zfish   690 AETSLTIDGIIYVIDPGFCKQKSYNAKTGMESLIVTPCSRASANQRAGRAGRVAAGKCFRLYTAW 754

  Fly   785 RFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDA 848
            .|: .:|:...||:.||.|..:.|.:|.|.:..:.||  ..::|||.:.::.|...|..:..|:.
Zfish   755 AFKHEMEETTVPEIQRTNLGNVVLLLKSLGINDLIHF--DFMDPPPHETLVLALEQLYALGALNH 817

  Fly   849 NDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKA 913
            ..|||.|||.:|.||::|.|.||::....:.|::.:..:|:..|..:.:|.....:...|::.:.
Zfish   818 LGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNNSIFYRPKDKVVHADNARM 882

  Fly   914 LSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQ 973
            .......||:.::.....|   .:.|  ...::|....:|..:|....|.:.||..|:.:
Zfish   883 NFVVPGGDHLVLLNVYTQW---VESG--YSTQWCFENFIQFRSMKRARDVRDQLEGLMDR 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	82/182 (45%)
		DEXDc	402..542	CDD:238005	64/146 (44%)
		ATP-synt_B	<584..644	CDD:304375	3/59 (5%)
		Helicase_C	643..772	CDD:278689	48/130 (37%)
		HA2	842..926	CDD:214852	21/83 (25%)
		OB_NTP_bind	974..1078	CDD:285018	199/645 (31%)
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923
		GBP_C	<177..296	CDD:303769
		coiled coil	271..285	CDD:293879
		DEXDc	407..594	CDD:214692	88/195 (45%)
		DEXDc	429..568	CDD:238005	64/147 (44%)
		Helicase_C	612..742	CDD:278689	48/131 (37%)
		HA2	811..895	CDD:214852	21/83 (25%)
		OB_NTP_bind	916..1028	CDD:285018	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810