DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and CG32533

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster

Alignment Length:	1045	Identity:	263/1045 - (25%)
Similarity:	427/1045 - (40%)	Gaps:	270/1045 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 KKSASKSCALSLVRQLFHLNVIEPFS---------GTLKKKKDEQLKPYPVKLSPN------LIN 273
            ||.|.:..:   .|:...:|:|| ||         |.|:.|..:..:    .|..|      .:.
  Fly     5 KKKADEHAS---SRRRTQINLIE-FSFLDHKAELVGLLQAKSRQVGR----SLVENEADFWKFVG 61

  Fly   274 KIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTW 338
            |.:.:::....||:.||..:.||               ||.|...:.:..
  Fly    62 KYEAMMRSTGQPVLPPRLAEAEL---------------SSMQPYHRSKHL--------------- 96

  Fly   339 HACNIDEGELATTSIDDLSMDYERSL---RDRRQND--NEYRQFLEFREKLPIAAMRSEILTAIN 398
             |..:|..||...:.|.:...:...|   .|.||.:  ...|:..:.:..||||..|.::..|::
  Fly    97 -ALRLDADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALD 160

  Fly   399 DNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGD 463
            .:.|||:.|:|||||:||:.||:.|       .||.:|..|||||::.:|:.:|||.|..:..|.
  Fly   161 TSRVVIVAGDTGCGKSTQVPQYLYD-------FGYRSIACTQPRRLACVSLCKRVAHELLDDYGS 218

  Fly   464 TVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDM 526
            .|.:.:|||....: ...|||.|.|:|||:|  .|.|.....:|:||||||::..||||.:.:.:
  Fly   219 RVAFQIRFERSRTK-LTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCL 282

  Fly   527 VDTYPDLHVILMSATIDTTKFSKYFGI--CPVLEVPGRAFPVQQFFLEDII------QMTDFVPS 583
            :...|.|.:|||||||:...|..|||.  ..:::||||.||::..:|....      |.|    |
  Fly   283 LRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQAT----S 343

  Fly   584 AESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIK 648
            ..|:|.|.:.....|:||            :.:.:|....|
  Fly   344 KRSQRNRIDPAPFVQVLS------------LIDQQYPTSER------------------------ 372

  Fly   649 SKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKI 713
                 |.:|:|:.|.|.|.::::.:.  ....:.:.:.:||.||.....:|.|||:..|||:.|.
  Fly   373 -----GDVLIFVSGVNEIESVVEAVH--EYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKC 430

  Fly   714 ILSTNIAETSITIDDIVFVID-----------ICKA-RMKLFTSHNNLTSYATVWASKTNLEQRK 766
            |:||||||||:|:|.:.||:|           .||. |:|.|            |.||::.:|||
  Fly   431 IVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEF------------WVSKSSADQRK 483

  Fly   767 GRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVD 831
            |||||..||.||.|.:..::.|.|...|||::|.||..|.|.:..:.|..:..|  ..:|.|..:
  Fly   484 GRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAF--PFIEAPETE 546

  Fly   832 AVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSE 896
            .:.:..:.|::...|...:::|||||.||.||:|..:|||:::|:||...:.:..:|:..|..:.
  Fly   547 RIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNP 611

  Fly   897 VFSLDIGQRRLANHQKALSGTKCSDH---VAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMN 958
            :.:.....:|....:::|.    |||   ..::....:|.:.|.|.:... ::|...|::.....
  Fly   612 LTNRAHTDQRCVRERESLE----SDHGDLFTLVRLYNVWVQLKMRRDGTR-QWCRRLGIEEQRFY 671

  Fly   959 VIWDAKQQLLDLLQQAGF------------------------------------PEECMI----- 982
            .:...:||...:|:..|.                                    |.:..:
  Fly   672 EVTKLRQQFQRILESCGMVVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSA 736

  Fly   983 -----SHEVDERIDGDDPVLDVSL----------------------------ALLCLGLYPNICV 1014
                 ..|..|...||| :.||..                            .||..|.||.:.:
  Fly   737 GRVAEDEEEQEEAQGDD-MRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAI 800

  Fly  1015 HKE-----------------------------KRKVLTTESKAALLHKTSVNCSNLAVTFPYPFF 1050
            ..|                             |...|...:::.||.|.......|.::..:...
  Fly   801 SDEFNYCKGGGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQLL 865

  Fly  1051 VFGEKIRTR---AVSCKQLSMVSPLQVILFGSRKIDLAAN-NIVRVDNWLNFDIEPELAAKIGAL 1111
            .:...:.|.   .::|.:|...   |.:|..|..||..|. ..:..|.||..|: |...:.:..|
  Fly   866 CYQSLLETAKPYLINCIRLPAA---QTLLLFSFAIDTNAGITQIACDGWLGLDL-PMPGSGMELL 926

  Fly  1112 KPALE 1116
            :.|:|
  Fly   927 RRAIE 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	4/15 (27%)
		DEXDc	393..569	CDD:214692	74/179 (41%)
		DEXDc	402..542	CDD:238005	61/141 (43%)
		ATP-synt_B	<584..644	CDD:304375	8/59 (14%)
		Helicase_C	643..772	CDD:278689	47/140 (34%)
		HA2	842..926	CDD:214852	24/86 (28%)
		OB_NTP_bind	974..1078	CDD:285018	26/209 (12%)
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	74/179 (41%)
		DEXDc	163..298	CDD:238005	61/142 (43%)
		Helicase_C	358..490	CDD:278689	53/186 (28%)
		HA2	560..640	CDD:214852	24/83 (29%)
		OB_NTP_bind	<792..897	CDD:285018	16/107 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468110
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850