Protein Alignment mle and CG1582

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 909
• Identity: 312/909 - (34%)
• Similarity: 480/909 - (52%)
• Gaps: 111/909 - (12%)

  Fly   316 DGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRD--RRQNDNEYRQFL 378
            |.|..|......:|..|.:.|       |.|.  ..:::..:.:..|.|:.  .|:.:..|::.:
  Fly   392 DAEHHQSPKPSHYARGQTSRN-------DGGH--QRNVEAQTRENRRLLQQFVERRKEERYQKII 447

  Fly   379 EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYI-------CSGQGGYANI 436
            :.|::||..|....||..|..:|||:|.|.|||||:||:.|:|||::.       ......:..|
  Fly   448 DGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEI 512

  Fly   437 YVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LR 499
            ..|||||:|||.||||||.||.:::|..|||.:|.|:...:. ..:.|||.|:|||:|.:.  |.
  Fly   513 ICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQS-TRLSFCTTGILLRRLASDPLLG 576

  Fly   500 GVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAF 564
            .|:|:||||:|||...|||||:||::::....||.|||||||::...||.|||..|||::|||.|
  Fly   577 SVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTF 641

  Fly   565 PVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYN------KVCEDK----- 618
            ||||.|||||::|:|||...:::..||..:.|:::|..:.:.|::..:      |:.::|
  Fly   642 PVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAE 706

  Fly   619 -------YSQKTRNAMAMLSESDVSFELLEALLMHI--KSKNIP--GAILVFLPGWNLIFALMKF 672
                   ||:.|..::.::....::.||:|::|.:|  .|.:.|  |.||:||||:..|.::...
  Fly   707 TYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDS 771

  Fly   673 LQNTNIFGD-TSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDIC 736
            |.:..:|.. ..::.::|.||.:..::|..||:..|.|..||:|||||||||:||||.|||:|..
  Fly   772 LLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCG 836

  Fly   737 KARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRT 800
            ..:.|.|.|:.|:.|...||.|:.|.:|||||||||.||.|..|.:..|:| .:.....||:.|.
  Fly   837 LMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRV 901

  Fly   801 PLHEMALTIKLLRLGSIHHFLS---KALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARL 862
            ||.::.|.||.|:..:..:.||   :.||.|..|:|:.|...||::..|||.|:|||||..||.|
  Fly   902 PLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAAL 966

  Fly   863 PIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIV 927
            |::.|:||:|:.||:|.|.|.:..:|:..|..|. |...:.:|..|:..|.:.....|||:.::.
  Fly   967 PVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSP-FVSPLNKRTEADKCKRMFALGNSDHLTVLN 1030

  Fly   928 ASQMWRREKQRGEHMEAR-FCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP------------EE 979
            |.:.|....:||.:..:| :.....|.::|:..|.|.|.|.|:||...||.            :.
  Fly  1031 AYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDN 1095

  Fly   980 CMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAAL-------------- 1030
            .:....|::..:||:..|..|  |||..|||||.......:|....:..|:
  Fly  1096 ILTLTGVEQNHNGDNNRLLTS--LLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTR 1158

  Fly  1031 ------LHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSR--KIDLAAN 1087
                  :|.:||| |.::| |..||.||.||:||.|:..:..||:..:.::||...  |::|...
  Fly  1159 GDGYVKIHPSSVN-SQVSV-FQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDG 1221

  Fly  1088 NIVRV--DNWLNFDIEPELAAKIGALKP-ALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCV 1148
            :.:.:  ..|:             .||. .||....|.|.....|..|||.       ::|.|:
  Fly  1222 DFLFLLESGWI-------------ILKAHDLETAEMVQCLRAEMIKLLEEK-------IRDPCL 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	97/243 (40%)
		HrpA	378..>889	CDD:441249	224/546 (41%)
		OB_NTP_bind	1002..1079	CDD:400182	30/96 (31%)
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871
		RWD_DHX57	175..367	CDD:467661
		zf-CCCH	245..272	CDD:459885
		HrpA	452..>1075	CDD:441249	245/624 (39%)
		OB_NTP_bind	1114..1212	CDD:400182	31/101 (31%)