Protein Alignment mle and kz

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Alignment Length: 1047
• Identity: 243/1047 - (23%)
• Similarity: 424/1047 - (40%)
• Gaps: 266/1047 - (25%)

  Fly   140 IDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAEL 204
            :|::|..:.:::.:...:.|.:......|...:.|.          |.....:..|..:.:.:..
  Fly    60 VDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLG----------DLAAVQIPEEELQQYTSIS 114

  Fly   205 SIYVPALNRTVTARESGSNKKS------ASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPY 263
            .:....|.|..|..|..:.||.      |.||.|..|     .:|.|:.....|..:::|:|:
  Fly   115 QVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGL-----RVNAIKGSKRKLLVEEEEELQ-- 172

  Fly   264 PVKLSPNLI------------NKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQD 316
            ..:.:||:|            ::.||.......|:..|..:.|   .||              |.
  Fly   173 AKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSI---APP--------------QI 220

  Fly   317 GEKRQESSVIPWAPPQANWNTWHAC---NIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFL 378
            ..|.....:.|...|.       ||   .:......||.:.:.
  Fly   221 AVKPPIKKLKPEPNPP-------ACIHQTVYVPVHRTTEVQNA---------------------- 256

  Fly   379 EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN---IYVTQ 440
              |.:|||.|...:::..||:||:||:.|.||.|||||:.|::.       :.|||.   |.||:
  Fly   257 --RLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLY-------EAGYAQHKMIGVTE 312

  Fly   441 PRRISAISVAERVARERCEQLGDT-VGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVS 502
            |||::||::::|||.|.  .|.:: |.|.:|||... .|...|.|.|.||||:::|..  |...|
  Fly   313 PRRVAAIAMSKRVAHEM--NLPESEVSYLIRFEGNV-TPATRIKFMTDGVLLKEIETDFLLSKYS 374

  Fly   503 HIIVDEIHERDVNSDFLLVILRDMVDTY----PDLHVILMSATI---DTTKFSKYFGI-CPVLEV 559
            .||:||.|||.|.:|.|:.:|..:|...    ..|.:|:||||:   |.|:.::.|.| .|:|:|
  Fly   375 VIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKV 439

  Fly   560 PGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVED---EEQLLSEDKDEAEINY---------- 611
            ..|.|||...|.:.  ...|:|  ||:.||..::.:   |..:|.....:.|:|.
  Fly   440 EARQFPVTIHFQKR--TPDDYV--AEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFP 500

  Fly   612 ------------NKVCEDKYSQKTRNAMAMLSE-SDVSFELLEALLMHIKSKNIPGAILVFLPGW 663
                        .||.|::..:...:|.:.:.: .::.|::...:      :||..:...||..
  Fly   501 YHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVI------RNIRKSKKKFLAQ- 558

  Fly   664 NLIFALMKF-LQNTNIFGDTSQYQ---------------------------------------IL 688
               .||.|. |.:..:.||.::..                                       :|
  Fly   559 ---MALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVL 620

  Fly   689 PCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYA 753
            |.:|.:..::|.::|.|||:|....::|||:||||:||..|.:|:|..:.:.:|:.....::::.
  Fly   621 PLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFV 685

  Fly   754 TVWASKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGSI 817
            ..:.||.:.:||.|||||:..|.|:.|.|.|.: ...||...|::.:.|:.::.|.::.:.:..:
  Fly   686 VTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRV 750

  Fly   818 HHFLSKALEPPPVDAVIEAEVLLREMRCLDA-------NDELTP----LGRLLARLPIEPRLGKM 871
            .||..    |.|.|.| :.:...|.:..|.|       |.:|.|    ||.:::|.|:.||.|||
  Fly   751 VHFPF----PSPPDQV-QLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKM 810

  Fly   872 MVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRR------LAN--HQKALSGTKCSDHV----A 924
            :.|............:.:..|. .||. ::.|.:|      .||  |:|..|.....::.    .
  Fly   811 LALSHQQNLLPYTVCLVAALSV-QEVL-IETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDP 873

  Fly   925 MIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQ----------------- 972
            |::...:...|....:.....||...||:...|:.:...:.||.:.:.
  Fly   874 MVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPP 938

  Fly   973 ---QAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKT 1034
               ||.|..:.::: .:.:|:....|:.|::              .||:|:.|          |.
  Fly   939 TDAQARFLRQILLA-GMGDRVARKVPLADIA--------------DKEERRRL----------KY 978

  Fly  1035 SVNCSNL 1041
            :.||:::
  Fly   979 AYNCADM 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	15/79 (19%)
		DEXHc_DHX9	326..559	CDD:350730	82/249 (33%)
		HrpA	378..>889	CDD:441249	170/602 (28%)
		OB_NTP_bind	1002..1079	CDD:400182	7/40 (18%)
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	201/782 (26%)
		DEXHc_DHX37	260..439	CDD:350740	75/188 (40%)