DRSC/TRiP Functional Genomics Resources

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Protein Alignment mle and Dhx36

DIOPT Version :9

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_001101148.1 Gene:Dhx36 / 310461 RGDID:1308767 Length:1000 Species:Rattus norvegicus


Alignment Length:1083 Identity:359/1083 - (33%)
Similarity:547/1083 - (50%) Gaps:177/1083 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 GGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEA 152
            ||||...:|:|..||..:.    .|..|....|....|.:..|.:.|..|:     ::|...|:.
  Rat    13 GGPRGSGQGSGGGGGGSRG----SGGGGGGRGGRGRHPAHLKGREIGLWYA-----KKQTQKNKE 68

  Fly   153 EAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTA 217
            ......|.:|.:...|....:|....|..|.:|..              |::|.:.|..:...| 
  Rat    69 AERQERAVVHMDERREEQIVQLLNSVQAKNDKDSE--------------AQISWFAPEDHGYGT- 118

  Fly   218 RESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGL 282
             |..|.||..|                        :||.|.|.|        .|:|:..:..:  
  Rat   119 -EVSSEKKINS------------------------EKKLDNQEK--------KLLNQEKKTYR-- 148

  Fly   283 DLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGE 347
                                 |.:.|.||.                               |...
  Rat   149 ---------------------ITDKSYIDR-------------------------------DSEY 161

  Fly   348 LATTSIDDLSMDYERSLRD--RRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTG 410
            |...:..:|.:| ::.|.|  :::.|..|.:...||:|||...|:.|::..||::.|.:|.|.||
  Rat   162 LLQQNEPNLGLD-QQLLEDLQKKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETG 225

  Fly   411 CGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQL--GDTVGYSVRFES 473
            ||||||:.|:|||:||..|.|....|..||||||||||||||||.||.|..  |::.||.:|.:|
  Rat   226 CGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQS 290

  Fly   474 VFPRPYGAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVI 536
            ..||..|:||:||.|::|:.|::.  |..||||::||||||::.||.|:.:::|::....||.||
  Rat   291 RLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVI 355

  Fly   537 LMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRR------------K 589
            |||||::..|||:|||.||::.:||..|||.::.|||||:...:.|..:..|            .
  Rat   356 LMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRGFMQGHVN 420

  Fly   590 RKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPG 654
            |:|.|::|.:..|....    |.|..:.:||..|.:.:.|:.:..|...|:.||:.:|..:...|
  Rat   421 RQEKEEKEAIYKERWPA----YIKELQTRYSASTIDVLEMMDDDKVDLNLIAALIRYIVLEEEDG 481

  Fly   655 AILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            |||||||||:.|..|...|.:..:| .:.::.|:|.||.:|...|.:||:..|.||.||:::|||
  Rat   482 AILVFLPGWDNISTLHDLLMSQVMF-KSDRFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNI 545

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            |||||||||:|:|||..|.:...|.:.||:::.:..|.||.|.:|||||||||:||.|:.|.:..
  Rat   546 AETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGL 610

  Fly   785 RFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDAN 849
            |...|:|...||:.||||.|:.|.||:||||.|.:|||:.::||..:||:.:...|.|:..||..
  Rat   611 RASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELSALDKQ 675

  Fly   850 DELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD-LMAIMASYSSTFSEVFSLDIGQRRLAN-HQK 912
            :||||||..|||||:||.:|||::.||:|.|.| ::.|.||.|  |.:.|.:.:|:.::|: .:|
  Rat   676 EELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLS--FKDPFVIPLGKEKIADARRK 738

  Fly   913 ALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWK-GLQMSTMNVIWDAKQQLLDLLQQAGF 976
            .|:....|||:.::.|.:.|...|:||...|..:| |: .|..:|:.::.:.|.|..:.|..|||
  Rat   739 ELAKETRSDHLTVVNAFEGWEEAKRRGFRYEKDYC-WEYFLSSNTLQMLHNMKGQFAEHLLGAGF 802

  Fly   977 PEECMISHEVDERIDGDDPVLDVS-------LALLCLGLYPNICVHK----EKRKVLTTESKA-- 1028
                     |..| ...||..:::       .|::|.||||.:...:    :|||::...:|:  
  Rat   803 ---------VSSR-SPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSDG 857

  Fly  1029 -ALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAA-----N 1087
             ..:|..|||...  ..|.|.:.::..|:||.::.....:.|||..::.||.   |::.     .
  Rat   858 LVSIHPKSVNVEQ--TDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGG---DISIQKDKDQ 917

  Fly  1088 NIVRVDNWLNFDIEPELAAKIGALKPALEDLI--TVACDNPSD 1128
            .|:.||.|:.|.....:|..:..|:..|:.|:  .:.|.:|.|
  Rat   918 EIIAVDEWIVFQSPERIAHLVKGLRKELDILLQEKIECPHPVD 960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM 4..68 CDD:214634
DSRM 170..240 CDD:214634 13/69 (19%)
DEXDc 393..569 CDD:214692 93/179 (52%)
DEXDc 402..542 CDD:238005 77/143 (54%)
ATP-synt_B <584..644 CDD:304375 15/71 (21%)
Helicase_C 643..772 CDD:278689 60/128 (47%)
HA2 842..926 CDD:214852 37/85 (44%)
OB_NTP_bind 974..1078 CDD:285018 29/117 (25%)
Dhx36NP_001101148.1 HrpA 187..893 CDD:224557 290/725 (40%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 257..309 29/51 (57%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 326..329 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 379..620 95/245 (39%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 490..549 23/59 (39%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1 509..520 4/10 (40%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 621..690 36/68 (53%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 630..689 29/58 (50%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 833..897 14/65 (22%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 841..852 3/10 (30%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 862..892 9/31 (29%)
Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..192 52/290 (18%)
Required for the pre-miR-134 transport. /evidence=ECO:0000269|PubMed:23651854 1..96 21/91 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53 13/43 (30%)
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..43 11/33 (33%)
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1 45..97 11/56 (20%)
DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1 45..67 5/26 (19%)
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 98..378 125/382 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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