DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Ythdc2

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_038953178.1	Gene:	Ythdc2 / 307446	RGDID:	1563192	Length:	1434	Species:	Rattus norvegicus

Alignment Length:	1366	Identity:	399/1366 - (29%)
Similarity:	566/1366 - (41%)	Gaps:	420/1366 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVID-RI 143
            |.....||||  ||       ||.|          ||...|.         |.||....:.| ||
  Rat     9 PRPPAPSGGG--TG-------GGGG----------GPASCGP---------GSGGRAKGLKDIRI 45

  Fly   144 QEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYV 208
            .|          :|..|::      .|.||.....|.     :.::........|:|:..||
  Rat    46 DE----------EVKIAVN------IALERFRYGDQR-----EMEFPSSLTSTERAFIHRLS--- 86

  Fly   209 PALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLIN 273
            .:|.....::..|:|:                :|.|         ||||.....:.: ::.||.:
  Rat    87 QSLGLVSKSKGKGANR----------------YLTV---------KKKDGSETAHAM-MTCNLTH 125

  Fly   274 KIDEVIKGL--DLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSV-------IPWA 329
            .....::.|  ..||.|....:         |:....|.:....:.|.|:.|..       ||..
  Rat   126 NTKHAVRSLIQRFPVTNKERTE---------LLPKTERGNVFAVEAENREMSKTSGRLNNGIPQV 181

  Fly   330 PPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEIL 394
            |            :..||                           .:|..||:.||:...:.||:
  Rat   182 P------------VKRGE---------------------------SEFDSFRQSLPVFEKQEEIV 207

  Fly   395 TAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCE 459
            ..|.:|.||:|.|.||.||||||.|::|||  |...|....|:.|||||::||:||||||.||.|
  Rat   208 KIIKENKVVLIVGETGSGKTTQIPQFLLDD--CFKNGIPCRIFCTQPRRLAAIAVAERVAAERRE 270

  Fly   460 QLGDTVGYSVRFES-VFPRPYGAILFCTVGVLLRKLEAG---LRGVSHIIVDEIHERDVNSDFLL 520
            ::|.|:||.:|.|| |.|:.  .:.|||.|||||.|.||   |..|:|:||||:||||..|||||
  Rat   271 RIGQTIGYQIRLESRVSPKT--LLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLL 333

  Fly   521 VILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMT------- 578
            ..|||::..:|.|.:||.||.:|...|.:|||.|||:.:.||.|.|::.|||||::.|
  Rat   334 TKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEM 398

  Fly   579 --------------------------DFVPSAESRRKRKEVEDEEQLLSEDKD-------EAEIN 610
                                      .|.|.::.:|....|.:|..||.:..|       |.::|
  Rat   399 LKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVN 463

  Fly   611 -----------------------------------YNKVCEDKYSQKTRNAMAM----------- 629
                                               .|...:.::|:.:..|:.:
  Rat   464 CLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVE 528

  Fly   630 ----------------------------------------------LSES--------DVSF--- 637
                                                          |.||        |:|.
  Rat   529 QLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDR 593

  Fly   638 ELLEA-------------LLMHIKSKNI-----PGAILVFLPGWNLIFALM-KFLQNTNIFGD-T 682
            |||:|             |:||: ..||     .||||:||||::.|..|. :.|.:...|.| |
  Rat   594 ELLKAYHHSFDDEKVDLDLIMHL-LYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNT 657

  Fly   683 SQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHN 747
            .:||:...||.:...:|:||.:..|.||.||||||||||||||::|:|||||..|.:.|.|.:.|
  Rat   658 HRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALN 722

  Fly   748 NLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLL 812
            .:|....||.||.:..||||||||.|||.||.|.||.|||.:.:..|||:.|.||.|:.|..|||
  Rat   723 FVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLL 787

  Fly   813 R--LGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLG 875
            .  ..:|..||.||.||||...|..|..:|:.:..:||.::||.||..||.||:||.||||::..
  Rat   788 APVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCA 852

  Fly   876 AVFGCAD---LMAIMASYSSTFSEVFSLDIGQRRLAN--HQKALSGTKCSDHVAMIVASQMWRRE 935
            .|..|.|   .:|...:|...|  |......|:|.|.  .::..:|| .|||:|::.|.|.|  :
  Rat   853 VVLKCLDPILTIACTLAYRDPF--VLPTQASQKRAAMLCRKRFTAGT-FSDHMALLRAFQAW--Q 912

  Fly   936 KQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVS 1000
            |.|.:..|..||:...|..:||.:|...:.|||..|:.:||         |..|..||  :.||:
  Rat   913 KARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGF---------VRARGGGD--IRDVN 966

  Fly  1001 L---------ALLCLGLYPNICVHKEKRKVLTT--ESKAALLHKTSV------------NCSNLA 1042
            .         |.|..|:|||: ||.::..|:.|  :.|....|.|||            |....|
  Rat   967 TNSENWAVVKAALVAGMYPNL-VHVDRENVVLTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAA 1030

  Fly  1043 V-TFPYPFFVFGEKIRT-RAVSCKQLSMVSPLQVILF---------------------------G 1078
            : ..|..:.::.|..|. |..:.:..|.|:|:.|::|                           .
  Rat  1031 IQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPARLTSNALQEPSSFRADGIPNDSSD 1095

  Fly  1079 SRKIDLAANNI--VRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQL-- 1139
            |...|....|:  :::|.||||.:|||.|:.:..|:.....|.......||      :|::|:
  Rat  1096 SEMEDRTTANLAALKLDEWLNFKLEPEAASLLLQLRQKWHSLFLRRMRAPS------KPWSQVDE 1154

  Fly  1140 --VKVVKDLCVKSAGDFGLQRESGI-----------LP-------HQSR------QFSDGGGPPK 1178
              ::.:..:........|||:.|||           ||       :.||      :||||....:
  Rat  1155 ATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSSADTEFSDGSTAAE 1219

  Fly  1179 R 1179
            |
  Rat  1220 R 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	11/69 (16%)
		DEXDc	393..569	CDD:214692	95/179 (53%)
		DEXDc	402..542	CDD:238005	80/143 (56%)
		ATP-synt_B	<584..644	CDD:304375	20/182 (11%)
		Helicase_C	643..772	CDD:278689	65/135 (48%)
		HA2	842..926	CDD:214852	32/88 (36%)
		OB_NTP_bind	974..1078	CDD:285018	34/155 (22%)
Ythdc2	XP_038953178.1	R3H_DEXH_helicase	50..108	CDD:100077	14/96 (15%)
		HrpA	193..>1020	CDD:224557	299/848 (35%)
		DEXHc_YTHDC2	197..372	CDD:350745	94/178 (53%)
		ANK repeat	509..541	CDD:293786	1/31 (3%)
		ANK repeat	543..571	CDD:293786	0/27 (0%)
		OB_NTP_bind	975..1070	CDD:400182	26/95 (27%)
		YTH	1293..1422	CDD:410979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920