DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx9

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001382485.1	Gene:	Dhx9 / 304859	RGDID:	1308548	Length:	1392	Species:	Rattus norvegicus

Alignment Length:	1386	Identity:	682/1386 - (49%)
Similarity:	914/1386 - (65%)	Gaps:	138/1386 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVN 66
            |||:|||.:|.|.::.|.::||..|.||||:|:||||||...|.|:|||||||||:.||.|||||
  Rat     3 DIKNFLYAWCGKRKMTPAYEIRAVGNKNRQKFMCEVRVEGFNYAGMGNSTNKKDAQSNAARDFVN 67

  Fly    67 YLVRVGKLNTNDVPA--------------DAGASG--------GGP-------RTGLEGAGMAGG 102
            ||||:.::.:.:|||              |:.||.        |||       :.....:|:...
  Rat    68 YLVRINEVKSEEVPAVGIVPPPPILSDTSDSTASTGEGLPPPMGGPLPPHLALKAAENNSGVESS 132

  Fly   103 SGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTI 167
            ||.      |..||          ..|.|.....|......||.:...|:|..|:||.:|||||:
  Rat   133 SGY------GSPGP----------TWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTL 181

  Fly   168 ENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCA 232
            ||||.|||.|.|...|:.:||||.|||:|.|||:||::||:..|.|.:.|||.|||||.|::|||
  Rat   182 ENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCA 246

  Fly   233 LSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELD 297
            |||||||:||.|||.:||..|||:.|:::||.|.|||:|..::..|::.|||.:|.|     .:|
  Rat   247 LSLVRQLYHLGVIEAYSGLTKKKEGERVEPYKVFLSPDLELQLQNVVQELDLEIVPP-----PVD 306

  Fly   298 GPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYER 362
             |.:|:|:|:.:: :..:..:::....|:||:|||:|||.|.:.|||||.||..|.:.:|||.:.
  Rat   307 -PSMPVILNIGKL-AHFEPSQRQNAVGVVPWSPPQSNWNPWTSSNIDEGPLAYASTEQISMDLKN 369

  Fly   363 SLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYIC 427
            .|..:.:.|:..:..|:.||.||:....:|||.||:.|.||||||.||||||||:.||||||:|.
  Rat   370 ELAYQMEQDHNLQSVLQERELLPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQ 434

  Fly   428 SGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLR 492
            :.:....||.|||||||||::||||||.||.|:.|.:.||||||||:.|||:.:|:|||||||||
  Rat   435 NDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLR 499

  Fly   493 KLEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVL 557
            |||||:||:||:|||||||||:|:|||||:|||:|..||::.::|||||||||.|.:||..||::
  Rat   500 KLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPII 564

  Fly   558 EVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQK 622
            ||.||.||||::||||.||||.|:|..:. :|:|:.||:.   .||.|   .|.|.:|.|:|..:
  Rat   565 EVYGRTFPVQEYFLEDCIQMTQFIPPPKD-KKKKDKEDDG---GEDDD---ANCNLICGDEYGPE 622

  Fly   623 TRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQI 687
            |:.:|:.|:|.:..|||:||||.:|::.|:|||:||||||||||:.:.|.|:|.:.|| :.:|||
  Rat   623 TKLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLENNSHFG-SHRYQI 686

  Fly   688 LPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSY 752
            ||.||||||:||||||:|||:||||:|||||||||||||:|:|:|||.||.::||||:|||:|:|
  Rat   687 LPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNY 751

  Fly   753 ATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSI 817
            ||||||||||||||||||||||||||.|||||||..||.::|||||||||||:||:|||||||.|
  Rat   752 ATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFDRLETHMTPEMFRTPLHEIALSIKLLRLGGI 816

  Fly   818 HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD 882
            ..||:||:||||:|||||||..|||:..||||||||||||:||:||||||.||||::|.:|...|
  Rat   817 GQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGD 881

  Fly   883 LMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFC 947
            .:..: |.::.|.|.|..:  .:||....:..:|.:.|||||::...|.|...:..||..|.|||
  Rat   882 AVCTI-SAATCFPEPFISE--GKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMSGEEAEIRFC 943

  Fly   948 DWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNI 1012
            :.|.|.|:|:.:.|:||.||.::|..:||||:|:::.....  .|.|..|||.::||..|:|||:
  Rat   944 EQKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTN--TGPDNNLDVVISLLAFGVYPNV 1006

  Fly  1013 CVHKEKRKVLTTESKAALLHKTSVNC--SNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVI 1075
            |.||||||:||||.:.||:||:||||  |:..:.:|.|||||||||||||:|.|.:::|:|||::
  Rat  1007 CYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLL 1071

  Fly  1076 LFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLV 1140
            ||.|:|:. :...||.:|:|:...|..|.||.|.||:.|:|.|:......|:.|.:|:.....::
  Rat  1072 LFASKKVQ-SDGQIVFIDDWIRLQISHEAAACITALRAAMEALVVEVSKQPNIISQLDPVNEHML 1135

  Fly  1141 KVVKDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGR------------------- 1186
            ..::.:...||.  |:....|     |.::.||..|||..|::.|.
  Rat  1136 NTIRQISRPSAA--GINLMIG-----SVRYGDGPRPPKMARYDNGSGYRRGYGGGGYGGGGYGGG 1193

  Fly  1187 FTNSSFG---RRGNGRTF--------GGGYGNNGGGYGNNGGGYGNIGGGY-------------- 1226
            :.:..||   ..|.|..|        |||:|:.|||:|:.|||:|..|||:
  Rat  1194 YGSGGFGGGFGSGGGGGFGGGFNSGGGGGFGSGGGGFGSGGGGFGGGGGGFSGGGGGGGFGGGRG 1258

  Fly  1227 GNNAGGYGNNGGYGNNGGGYRNNGGGYGNNG--GGYGNKRGGFG----------------DSFES 1273
            |...||:|.:||:|:.||||...|||||..|  ||||...||:|                :|:..
  Rat  1259 GGGGGGFGGSGGFGSGGGGYGVGGGGYGGGGGSGGYGGGSGGYGGGGGGYGGGEGYNMSPNSYRG 1323

  Fly  1274 N-RGSGGGFRNGDQGGRWGNF 1293
            | .|.|||:|.|.|||...||
  Rat  1324 NYGGGGGGYRGGSQGGYRNNF 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	39/63 (62%)
		DSRM	170..240	CDD:214634	43/69 (62%)
		DEXDc	393..569	CDD:214692	120/175 (69%)
		DEXDc	402..542	CDD:238005	97/139 (70%)
		ATP-synt_B	<584..644	CDD:304375	21/59 (36%)
		Helicase_C	643..772	CDD:278689	93/128 (73%)
		HA2	842..926	CDD:214852	40/83 (48%)
		OB_NTP_bind	974..1078	CDD:285018	57/105 (54%)
Dhx9	NP_001382485.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341989
Domainoid	1	1.000	220	1.000	Domainoid score	I2549
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1039
Inparanoid	1	1.050	1193	1.000	Inparanoid score	I180
OMA	1	1.010	-	-		QHG45656
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0006547
OrthoInspector	1	1.000	-	-		oto98495
orthoMCL	1	0.900	-	-		OOG6_105518
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4785
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910