DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Tdrd9

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_017450003.1	Gene:	Tdrd9 / 299343	RGDID:	1306942	Length:	1396	Species:	Rattus norvegicus

Alignment Length:	914	Identity:	276/914 - (30%)
Similarity:	425/914 - (46%)	Gaps:	181/914 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 IELDG--PPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDL 356
            :||.|  |..|          ::...|:.|.|..:|...|.|.         .:..:..|::...
  Rat    23 VELLGLPPAFP----------AEAPREEVQRSEEVPSEAPTAQ---------AQDPVKATALARP 68

  Fly   357 SMDYERSLRDRR---QNDNEYRQFLEFRE------------------------------------ 382
            :..:.|||..|.   :..|:||| ||.:|
  Rat    69 ASAFGRSLSQRSSEVEYINKYRQ-LEAQELDIYGQDQPPSGPGLRSPLAKISNVACIPETTYKYP 132

  Fly   383 KLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAI 447
            .|||...:.|:::.|..|.||||.|.||.||:||:.||:||.|  :.:..:.||.|||||:|.|.
  Rat   133 DLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHY--TQRSAFCNIVVTQPRKIGAS 195

  Fly   448 SVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEA--GLRGVSHIIVDEIH 510
            |:|..:::||...||..|||.|..|...... ..:::.|.||||:|:.:  .|...:|:.:||:|
  Rat   196 SIARWISKERSWTLGGLVGYQVGLEKTATED-TRLIYMTTGVLLQKIVSAKSLMEFTHVFIDEVH 259

  Fly   511 ERDVNSDFLLVILRDMVDTYPD-LHVILMSATIDTTKFSKYFGI--------CPVLEVPGRAFPV 566
            ||....||||:::|.::.|... :.||||||||:..:|:.||.:        ..|.||.|:...:
  Rat   260 ERTEEMDFLLLVVRKLLRTNSRFVKVILMSATINCKQFADYFAVPVQNKMNPAYVFEVEGKPHTI 324

  Fly   567 QQFFLEDI--IQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCED----KYSQKTRN 625
            :|::|.|:  |..:...|          ...||.::::|..|..::..::.:|    :...||.:
  Rat   325 EQYYLNDLGHIYHSGLPP----------YRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWS 379

  Fly   626 AMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPC 690
            ....:||.                    .::||||||...|..:.:.|  ||:.  ..:.|:.|.
  Rat   380 GAQFVSER--------------------SSVLVFLPGLGEINYMHELL--TNMI--HKRLQVYPL 420

  Fly   691 HSQIPRDEQRKVF-EPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYAT 754
            ||.:..:||..|| .||| |..||||||||||:|:|:.|:.:|||.|..|..:.....|..|...
  Rat   421 HSSVTLEEQNNVFLSPVP-GYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRL 484

  Fly   755 VWASKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGSIH 818
            .|||||:.:|||||||||..|:|:.|..|..: .|:.|::.|||.|.||....|.:|||.:|...
  Rat   485 SWASKTSCDQRKGRAGRVSKGYCYRLIHRDFWDSAIPDHVVPEMLRCPLGSTVLKVKLLDMGEPR 549

  Fly   819 HFLSKALEPPPVDAVIEAEVLLREMRCL-------DAN---DELTPLGRLLARLPIEPRLGKMMV 873
            ..|:.||.||.:..:....:||:|:..|       |.|   .|||.|||:||:||:..:|||::|
  Rat   550 ALLATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLIV 614

  Fly   874 LGAVFGCAD---LMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRRE 935
            ||.||||.|   ::|...|..:.|:..|...:...|...|   .||:..||.:|::.|.:.|:..
  Rat   615 LGHVFGCLDECLIIAAALSLKNFFTMPFRQHLDGYRNKVH---FSGSSRSDCLALVEAFRAWQAC 676

  Fly   936 KQRGE--HMEARFCDWKGL---QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDP 995
            :||||  |.:... ||..|   |:..:..:.:..::|.:.:.|        .:..||.|    .|
  Rat   677 RQRGELRHPKDEL-DWGRLNYIQIKRIREVAELYEELKNRISQ--------FNMFVDPR----HP 728

  Fly   996 VLD---------VSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFV 1051
            |||         :...:|....|||.....:..:.:.....|....||:|...::.   ||.|..
  Rat   729 VLDQEYPYKQRFILQVVLAGAFYPNYFTFGQPDEEMAVRELAGRDPKTTVVLKHIP---PYGFLY 790

  Fly  1052 FGEKIRTRAVSCKQLSMVSPLQVILFGSRK--IDLAANNIVRVDNWLNFDIEP--ELAAKIGALK 1112
            : :::::....|.|      ::.|:|...|  ::.:.|...|      |...|  .||.|:..||
  Rat   791 Y-KQLQSLFRQCGQ------VKSIVFDGAKAFVEFSRNPTER------FKTLPAVNLAVKMSQLK 842

  Fly  1113 PALE 1116
            .:||
  Rat   843 VSLE 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	72/186 (39%)
		DEXDc	402..542	CDD:238005	61/142 (43%)
		ATP-synt_B	<584..644	CDD:304375	9/63 (14%)
		Helicase_C	643..772	CDD:278689	54/129 (42%)
		HA2	842..926	CDD:214852	36/96 (38%)
		OB_NTP_bind	974..1078	CDD:285018	21/112 (19%)
Tdrd9	XP_017450003.1	DEXDc	146..327	CDD:214692	72/183 (39%)
		DEXDc	151..292	CDD:238005	61/143 (43%)
		Helicase_C	385..502	CDD:278689	56/141 (40%)
		HA2	590..667	CDD:214852	32/79 (41%)
		TUDOR	924..1026	CDD:278965
		TUDOR	962..1009	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920