Protein Alignment mle and Dhx16

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_997661.1
• Gene: Dhx16 / 294232
• RGDID: 1302963
• Length: 1044
• Species: Rattus norvegicus
• Alignment Length: 988
• Identity: 254/988 - (25%)
• Similarity: 414/988 - (41%)
• Gaps: 243/988 - (24%)

  Fly   100 AGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGN 164
            |..||  ||...|...|.:    .:|.:.|..:...|    :|:|   |:.|.:||
  Rat   141 ASESG--KRKTGGSKSPTE----EKPASEDEWERTER----ERLQ---DLEERDAF--------- 183

  Fly   165 WTIENAKERLNIYKQTNNI--RDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSA 227
              .|..::|..  .:|.|:  |.|.|......:..:....:....||.|           .|||.
  Rat   184 --AERVRQRDK--DRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPEL-----------RKKSR 233

  Fly   228 SKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKG-LDLPVVNPRN 291
            .:                     .|.|::.|:|:....:|:.      :||:.| ::|.....|.
  Rat   234 RE---------------------YLAKREREKLEDLEAELAD------EEVLFGDVELSRHERRE 271

  Fly   292 IKIELDGPPIPLIVNLSRIDSSQQDGEK------------------------RQESSVIPWAPPQ 332
            :|.:      ..:.:|:|...:..:.||                        .:||..     |.
  Rat   272 LKYK------RRVRDLAREYRAAGEQEKLEATNRYHMPKETRGQPARATDIVEEESGA-----PG 325

  Fly   333 ANWNTWHACNIDEGELATTSID--------------DLSMDYERSLRDRRQNDNE---------- 373
            .....|....:|...|...:.|              |.::::.|:.  :.|.|.|
  Rat   326 EEQRRWEEARLDAASLKFGARDAAAQEPQYQLVLEEDETIEFVRAA--QLQGDEEPSSGPPLSAQ 388

  Fly   374 --YRQFLE-FREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYA- 434
              .::.:: .|..||:...|.|:||||.::.|:||.|.||.||||||.||:.::       ||.
  Rat   389 AQQKESIQAVRRSLPVFPFREELLTAIANHQVLIIEGETGSGKTTQIPQYLFEE-------GYTK 446

  Fly   435 ---NIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL-- 494
               .|..|||||::|:|||.|||||...:||:.||||:|||.. ......:.:.|.|:|||:.
  Rat   447 KGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDC-TSERTVLRYMTDGMLLREFLS 510

  Fly   495 EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEV 559
            |..|...|.::|||.|||.:::|.|..:::|:....|:|.|::.|||:||.:||.:|...||..:
  Rat   511 EPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATLDTARFSAFFDDAPVFRI 575

  Fly   560 PGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTR 624
            |||.|||..|:.:        .|.|:                         |.:.|
  Rat   576 PGRRFPVDIFYTK--------APEAD-------------------------YLEAC--------- 598

  Fly   625 NAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQN--TNIFGDTSQYQI 687
                          ::..|.:|:...  ||.|||||.|...|.|..:.||:  ..:.....:..:
  Rat   599 --------------VVSVLQIHVTQP--PGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLV 647

  Fly   688 LPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSY 752
            ||.::.:|.|.|.::|:|.|.|..|::::|||||||:||:.|::|:|....:.|.:.....:.|.
  Rat   648 LPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESL 712

  Fly   753 ATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGS 816
            .....||.:..||.||||||..|.||.|.:...:| .||:...||:.||.|..:.|.:|.|.:..
  Rat   713 TVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHD 777

  Fly   817 IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCA 881
            :.||  ..|:|||.:.::.|...|..:..|:...|||..||.:|.||::|.|.||::....:.|:
  Rat   778 LMHF--DFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCS 840

  Fly   882 DLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARF 946
            :.:..:|:..|..:.:|.....:...|::.:........||:.::.....|..     ....:::
  Rat   841 EEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAE-----SGYSSQW 900

  Fly   947 CDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPN 1011
            |....:|..:|....|.::||..||::                       ::|.|. .|.|.|..
  Rat   901 CYENFVQFRSMRRARDVREQLEGLLER-----------------------VEVGLT-SCQGDYVR 941

  Fly  1012 ICVHKEKRKVLTT 1024
            :      ||.:|:
  Rat   942 V------RKAITS 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	13/75 (17%)
		DEXHc_DHX9	326..559	CDD:350730	89/265 (34%)
		HrpA	378..>889	CDD:441249	175/520 (34%)
		OB_NTP_bind	1002..1079	CDD:400182	6/23 (26%)
Dhx16	NP_997661.1	PTZ00121	<146..>410	CDD:173412	57/338 (17%)
		HrpA	401..>1028	CDD:441249	197/651 (30%)