DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and Dhx15

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001178526.1	Gene:	Dhx15 / 289693	RGDID:	1308072	Length:	795	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	199/678 - (29%)
Similarity:	330/678 - (48%)	Gaps:	93/678 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYV 438
            |...|:.|.:||:...:......:..:...::.|.||.||||||.|:.: :|:.|..|....:..
  Rat   127 YYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCV-EYMRSLPGPKRGVAC 190

  Fly   439 TQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAIL-FCTVGVLLRKL--EAGLRG 500
            |||||::|:|||:|||.|....||..||||:|||......  .|| :.|.|:|||:.  :..|..
  Rat   191 TQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAK--TILKYMTDGMLLREAMNDPLLER 253

  Fly   501 VSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFP 565
            ...||:||.|||.:.:|.|:.:|:::|....||.||:||||:|..||..||..||:|.:|||..|
  Rat   254 YGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHP 318

  Fly   566 VQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAML 630
            |:.|          :.|..|                .|..||.|            :|...:.|.
  Rat   319 VEIF----------YTPEPE----------------RDYLEAAI------------RTVIQIHMC 345

  Fly   631 SESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQN--TNIFGDTSQYQILPCHSQ 693
            .|.:                   |.:|:||.|...|....|.::.  .::..:....:|:|.:|.
  Rat   346 EEEE-------------------GDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYST 391

  Fly   694 IPRDEQRKVFEPVP----EGV--TKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSY 752
            :|..:|:::|||.|    .|.  .|:::||||||||:|||.:|||||...|:.|::.....:.|.
  Rat   392 LPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESL 456

  Fly   753 ATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQA-LEDNLTPEMFRTPLHEMALTIKLLRLGS 816
            .....||.:.:||.|||||.|||.||.|.:...::. ::||..||:.|:.|..:.|.:|.|.:..
  Rat   457 LVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDD 521

  Fly   817 IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCA 881
            :.||  ..::||..:.::.|..||..:..|:.:.:||.||.::|..|::|:|.||::....:.|:
  Rat   522 LVHF--DFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCS 584

  Fly   882 -DLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEAR 945
             ::::|.|..|  ..:.|......::.|:..|........||:.::.....:::..:..:.....
  Rat   585 NEVLSITAMLS--VPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDN 647

  Fly   946 FCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYP 1010
            |.:::.| ||..||    :|||..::.:...|..   |.:...|    |..:::..||: .|.:.
  Rat   648 FINYRSL-MSADNV----RQQLSRIMDRFNLPRR---STDFTSR----DYYINIRKALV-TGYFM 699

  Fly  1011 NICVHKEK--RKVLTTESKAALLHKTSV 1036
            .: .|.|:  ..:...:::...||.::|
  Rat   700 QV-AHLERTGHYLTVKDNQVVQLHPSTV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	75/178 (42%)
		DEXDc	402..542	CDD:238005	61/142 (43%)
		ATP-synt_B	<584..644	CDD:304375	8/59 (14%)
		Helicase_C	643..772	CDD:278689	45/136 (33%)
		HA2	842..926	CDD:214852	20/84 (24%)
		OB_NTP_bind	974..1078	CDD:285018	12/65 (18%)
Dhx15	NP_001178526.1	HrpA	124..763	CDD:224557	199/678 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810