DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx37

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001099396.2	Gene:	Dhx37 / 288647	RGDID:	1306837	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	824	Identity:	218/824 - (26%)
Similarity:	349/824 - (42%)	Gaps:	193/824 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 NEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN- 435
            |...:..|.|.||||.|....|:.|:.::|:||:.|.||.|||||:.|::.       :.||::
  Rat   236 NRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLY-------EAGYSSE 293

  Fly   436 ---IYVTQPRRISAISVAERVARERCEQLGD-TVGYSVRFESVFPRPYGAILFCTVGVLLRKLEA 496
               |.||:|||::|:::::|||:|.  .|.. .|.|.:|:|...... ..|.|.|.||||::::.
  Rat   294 DSIIGVTEPRRVAAVAMSQRVAKEM--NLSHRVVSYQIRYEGNVTEE-TRIKFMTDGVLLKEIQK 355

  Fly   497 GLRGVSH--IIVDEIHERDVNSDFLLVILRDMV----DTYPDLHVILMSATI---DTTKFSKYFG 552
            ....:.:  :|:||.|||.|.:|.||.:|..:|    ..:..|.:::||||:   |.|:..:.|.
  Rat   356 DFLLLKYKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFT 420

  Fly   553 I-CPVLEVPGRAFPVQQFF-----LED--------IIQMTDFVPS--------------AESRRK 589
            . .||::|..|.|||...|     |:|        :.::...:|:              |..||.
  Rat   421 TPPPVIKVESRQFPVTVHFNKRTPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRL 485

  Fly   590 RKEVE---DEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAML----------------SESDV 635
            ||...   .:.|.:.||..|....:.     |...:.|.|.||.                .:.|.
  Rat   486 RKAFPIRCSQPQEMEEDSAEGMRRFK-----KSRTRARKAQAMALPQINLDNYSVLPAGEGDEDR 545

  Fly   636 SFEL---LEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTS-QYQILPCHSQIPR 696
            ..|:   .|||                  |.:|...|.....|.....|.| ...:||.:|.:..
  Rat   546 EAEMDDEEEAL------------------GSDLDLDLGDSEANEGEQPDASLPLHVLPLYSLLAP 592

  Fly   697 DEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTN 761
            ::|.:||:|.|||....:::||:||||:||..|.:|:|..|.:.:.:.....::|:...|.|:.:
  Rat   593 EKQAQVFKPPPEGTRLCVIATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQAS 657

  Fly   762 LEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALE 826
            .:||.|||||..||.|:.|.|.|.|...|....||:.|.|:.::.|.:|.|.:..:.:|....
  Rat   658 ADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNIEKVINFPFPT-- 720

  Fly   827 PPPVDAVIEAEVLLREMRCLDANDE---------------LTPLGRLLARLPIEPRLGKMMVLGA 876
            ||.|:|:|.||.||..:..|.|..:               :|.|||.::..|:.||..||:.|..
  Rat   721 PPSVEALIAAEELLIALGALQAPPKQERMKKLQMSQLSCPITALGRTMSTFPVAPRYAKMLALSQ 785

  Fly   877 VFGCAD-LMAIMASYSSTFSEVF-SLDIGQRRLANHQK--ALSGTKCSDHVAMIVASQMWRREKQ 937
            ..||.. .:||:|  :.|..|:| .||   |..|:.::  .|.|.:..       .:||.|....
  Rat   786 QHGCLPYTIAIVA--AMTVRELFEELD---RPAASEEELAELKGRRTR-------VAQMKRTWAG 838

  Fly   938 RGEHME--------------------ARFCDWKGLQMSTMNVIWDAKQQLLDLLQ----QAGF-- 976
            :|..::                    .:||...||:...|..|...:.||...:.    :||.
  Rat   839 QGASLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTAVNAVCPEAGLFL 903

  Fly   977 ------PEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAA------ 1029
                  |.|..:::               ...::..||..::....:...:|..:.|.|
  Rat   904 DPKMQPPTESQVTY---------------LRQIMAAGLGDHLARRVQSEDLLDPKWKNAYKTPLL 953

  Fly  1030 ----LLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMV 1069
                .:|.:||....|.     .|.|:.|.:.|..:..|.:|.|
  Rat   954 DDPVFIHPSSVLFRELP-----EFVVYQEIVETTKMYMKGVSTV 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	66/190 (35%)
		DEXDc	402..542	CDD:238005	52/150 (35%)
		ATP-synt_B	<584..644	CDD:304375	18/81 (22%)
		Helicase_C	643..772	CDD:278689	38/129 (29%)
		HA2	842..926	CDD:214852	26/102 (25%)
		OB_NTP_bind	974..1078	CDD:285018	20/114 (18%)
Dhx37	NP_001099396.2	HrpA	236..1009	CDD:224557	218/824 (26%)
		DEXDc	267..407	CDD:238005	52/149 (35%)
		HELICc	578..667	CDD:197757	31/88 (35%)
		HA2	730..781	CDD:282288	14/50 (28%)
		HA2	761..852	CDD:214852	28/102 (27%)
		OB_NTP_bind	887..1004	CDD:285018	22/126 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810