DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx40

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001005873.1	Gene:	Dhx40 / 287595	RGDID:	1359618	Length:	779	Species:	Rattus norvegicus

Alignment Length:	826	Identity:	223/826 - (26%)
Similarity:	360/826 - (43%)	Gaps:	147/826 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 PIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISV 449
            ||...|.:::.|:.||..:|:.||||.|||||:.:|:.:    :|...:..|.|||||:::||||
  Rat    54 PIQKQRKKLIQAVRDNSFLIVTGNTGSGKTTQLPKYLYE----AGFSQHGMIGVTQPRKVAAISV 114

  Fly   450 AERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHER 512
            |:|||.|....||..|||.|||:....:. .||.:.|.|.||:.:  :..|...|.||:||.|||
  Rat   115 AQRVAEEMKCTLGSKVGYQVRFDDCSSKE-TAIKYMTDGCLLKHILGDPNLNKFSVIILDEAHER 178

  Fly   513 DVNSDFLLVILRDMV-DTYPD----LHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLE 572
            .:.:|.|..:|:.:. |..|:    |.|::||||::..|.|.:||.||:.::|||.:||::.|.
  Rat   179 TLTTDILFGLLKKLFQDKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFC- 242

  Fly   573 DIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSF 637
            ::|...|                                                   .|:....
  Rat   243 NLIGPRD---------------------------------------------------RENTAYI 256

  Fly   638 ELLEALLMHIKSKNIPGAILVFLPG-------WNLIFALMKF------LQNTNIFGDTSQYQILP 689
            :.:..:.|.|....:.|.|||||.|       ..|:|.:.:.      :|:|.:.|    ..|||
  Rat   257 QAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDG----LLILP 317

  Fly   690 CHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHN---NLTS 751
            |:..:..|:||::|.|.|.|:.|.::||||:.||:|||.|.:|:|....:.   .:||   .|..
  Rat   318 CYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQ---LNHNPRLGLDI 379

  Fly   752 YATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLG 815
            ...|..||:...||.|||||...|.||.:.|:..: |.:.|::.||:.||.|..:.||:|.|.:.
  Rat   380 LEVVPISKSEALQRSGRAGRTASGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIH 444

  Fly   816 SIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGC 880
            .:..|  ..|:||....::||...|.:...:|.:..:|.||..:...|:.|.|...::..|...|
  Rat   445 DVIRF--PYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIRAASLDC 507

  Fly   881 ADLM---AIMASYSSTFSEVFSLDIGQRRLANHQK-ALSGTKCSDHVAMIVASQMWRREKQRGEH 941
            .||:   |.|.|..:.|......:..:.....|:: |......:|...:.|..:..:........
  Rat   508 EDLLLPIAAMLSVENVFIRPVDPEYQKEAEQKHRELAAKAGGFNDFATLAVIFEQCKSSGAPASW 572

  Fly   942 MEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCL 1006
            .:..:..|:.| .|...|....::.:..|.||:.||.|..           :.|..:|....||.
  Rat   573 CQKHWIHWRCL-FSAFRVEAQLRELIRKLKQQSDFPRETF-----------EGPKHEVLRRCLCA 625

  Fly  1007 GLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSP 1071
            |.:.|:......|...|.:.:.:.:|....:..:...| ...:.:|.|.:.|..|..:   :|.|
  Rat   626 GYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQET-KLEWIIFHEVLVTTKVYAR---IVCP 686

  Fly  1072 LQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPY 1136
            ::.                   .|:. |:.|:| .::.|     .||.:||.....|..|.:...
  Rat   687 IRY-------------------EWVR-DLLPKL-HELNA-----HDLSSVARREMRDDARRKWTN 725

  Fly  1137 AQLVKVVKDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRF 1182
            .:.||.:||         |:.:|  :|....|:..|......|.||
  Rat   726 KENVKQLKD---------GISKE--VLKKMQRRNDDKSISDARARF 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	75/182 (41%)
		DEXDc	402..542	CDD:238005	60/146 (41%)
		ATP-synt_B	<584..644	CDD:304375	1/59 (2%)
		Helicase_C	643..772	CDD:278689	50/144 (35%)
		HA2	842..926	CDD:214852	18/87 (21%)
		OB_NTP_bind	974..1078	CDD:285018	19/103 (18%)
Dhx40	NP_001005873.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HrpA	51..750	CDD:224557	219/814 (27%)
		DEAH box	173..176		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810