DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and Dhx33

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001099272.1	Gene:	Dhx33 / 287464	RGDID:	1307239	Length:	698	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	194/635 - (30%)
Similarity:	305/635 - (48%)	Gaps:	98/635 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 RRQ-------NDNEYRQFLEF-REKLPIAAMRSEILTAIN--DNPVVIIRGNTGCGKTTQIAQYI 421
            |||       :.:.||:.||. |..|||...|.::|..:.  ||.|:|  |.||.||||||.||:
  Rat    40 RRQTPPLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLI--GETGSGKTTQIPQYL 102

  Fly   422 LDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCT 486
            .:..| |.||   .|.||||||::|||:|.||:.|:..:||..|||:||||.|.... ..|.|.|
  Rat   103 YEGGI-SRQG---IIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSED-TRIKFLT 162

  Fly   487 VGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVIL------RDMVDTYPDLHVILMSATID 543
            .|:|||:.  ::.||..|.:|:||.|||.:::|.|..::      |..:...| |.||:||||:|
  Rat   163 DGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLP-LKVIVMSATMD 226

  Fly   544 TTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAE 608
            ...||:||...|||.:.||..|:|.|:.:...|  |::.:|
  Rat   227 VDLFSQYFNGAPVLYLEGRQHPIQIFYTKQPQQ--DYLHAA------------------------ 265

  Fly   609 INYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGA--ILVFLPGWNLIFALMK 671
                                          |:....:|   :..|.:  |||||.|...|.|:.|
  Rat   266 ------------------------------LVSVFQIH---QEAPSSQDILVFLTGQEEIEAMSK 297

  Fly   672 FLQN--TNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVID 734
            ..::  .::........:||.::.:|..:|.:||:..|:|..|:|:|||||||||||..|.:|:|
  Rat   298 TCRDIAKHLPDGCPSMLVLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVD 362

  Fly   735 ICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFR 799
            ....:.|.:...:.|...|....|||...||.|||||...|.|:.|.:...|...|....||:.|
  Rat   363 TGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFDKFEKMAAPEIQR 427

  Fly   800 TPLHEMALTIKLLRLGSI--HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARL 862
            ..|..:.|.:..:::.::  ..|:|:. .|..::|.|....||..:...|....|||:||.:|..
  Rat   428 CNLASVMLQLLAMKVPNVLTFDFMSRP-SPDHIEAAIAQLDLLGALEHKDDQLALTPIGRKMAAF 491

  Fly   863 PIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIV 927
            |:||:..|.::|.:.|.|.:.:..:.|..|..|.:::....:..:.:.:|....:: .||:.::
  Rat   492 PLEPKFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSE-GDHITLL- 554

  Fly   928 ASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP 977
              .::|..|..|.:.:  :|....:....|.::.:.:.||.|:..:...|
  Rat   555 --NIYRTFKNIGGNKD--WCKENFVNSKNMLLVAEVRAQLRDICLKMSMP 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	83/185 (45%)
		DEXDc	402..542	CDD:238005	67/147 (46%)
		ATP-synt_B	<584..644	CDD:304375	2/59 (3%)
		Helicase_C	643..772	CDD:278689	47/132 (36%)
		HA2	842..926	CDD:214852	20/83 (24%)
		OB_NTP_bind	974..1078	CDD:285018	1/4 (25%)
Dhx33	NP_001099272.1	DEXDc	49..252	CDD:214692	92/210 (44%)
		DEXDc	83..225	CDD:238005	68/149 (46%)
		Helicase_C	282..399	CDD:278689	44/116 (38%)
		HA2	469..554	CDD:214852	21/85 (25%)
		OB_NTP_bind	588..688	CDD:285018	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810