DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and SPBC15C4.05

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_595925.1	Gene:	SPBC15C4.05 / 2539831	PomBaseID:	SPBC15C4.05	Length:	1428	Species:	Schizosaccharomyces pombe

Alignment Length:	1076	Identity:	299/1076 - (27%)
Similarity:	498/1076 - (46%)	Gaps:	219/1076 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 QEQRDMNEAEAFDVNAAIHGNWTI-----------ENAKERLNIYKQTNNIRDDYKYTPVGPEHA 197
            ||:.|:.:.|    |..::.|:|:           .:...:..::|..:||:.::|..|:|
pombe   426 QEEEDIQDTE----NDLLNANYTLLPLTTDKSGTRPSTTLQYELHKIGSNIKAEFKTMPIG---- 482

  Fly   198 RSFLAELSIYVPALNRTVTARESGSNKKSASKSCALS--------LVR----------QLFHLNV 244
                 ::........|..|.:::.|:.|:...:..|:        |.|          |.|..:.
pombe   483 -----KIGYQSTCFVRCSTGQKTFSDLKTVLPTATLAADYISMIVLFRLMANFTKISLQTFPKSF 542

  Fly   245 IEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSR 309
            .|.:.....:|::..|.. ..|:|    .|:|.:||..:|..               |.....|:
pombe   543 KEVYGKFSAEKQNTDLAE-DAKIS----EKLDSIIKSKELET---------------PTSATTSK 587

  Fly   310 IDSSQQD-----GEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQ 369
            :.:...:     |.:|         ||:...|.|                            |:|
pombe   588 LMAPMDNIGKFSGFER---------PPETLLNKW----------------------------RQQ 615

  Fly   370 NDNE-YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGY 433
            .::| ..:|..||.:||....|..|:.|:|::.::||.|:|||||:|||..::|::...:|:.
pombe   616 LESESAEKFKVFRNQLPATMFRETIIDAVNNSQLLIISGDTGCGKSTQIPAFLLENSTKNGKA-- 678

  Fly   434 ANIYVTQPRRISAISVAERVARERCEQLG---------DTVGYSVRFESVFPRPYGAILFCTVGV 489
            ..||||:||||||||:|.||::|    ||         :.||||||.:|.. .|...:.:.|.|.
pombe   679 VKIYVTEPRRISAISLANRVSQE----LGGNPPSARSHELVGYSVRLDSKC-TPLTPLTYVTTGT 738

  Fly   490 LLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFG 552
            .||.||.|  :..|:|:|:||:|||.::||.||:.:..::..:|.|.:|:||||::..||..||.
pombe   739 FLRLLEVGNEIESVTHLIIDEVHERSIDSDLLLIHVLHLLKQHPHLKIIIMSATLNAEKFQLYFE 803

  Fly   553 ICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCED 617
            ...::.:||:.:||.:|:||||:.......|..:...:..:|:::  ...|:.:|.|: ||..||
pombe   804 GSNLITIPGKTYPVHRFYLEDILSQFGNDKSFGNAAGQDVIEEDD--YETDQQDASIS-NKSAED 865

  Fly   618 KYSQKTRNAM-AMLSESDVSFELLEALLMHIKSKNIP---GAILVFLPGWNLIFALMKFLQNTNI 678
            ...:  .|.: |..:|..:::.|:..||.:|.::..|   ..:||||||.:.|..:...:::..:
pombe   866 AIVE--MNLIPAWYNEKAINYGLIVYLLKYIFTEGDPKFSKCVLVFLPGISEILRVKSLIEDMPM 928

  Fly   679 FGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLF 743
            |.:..::.|...||.:...:|:.||...|:|..||:||||||||.:||.|:..|||....|...:
pombe   929 FRNHRKFCIYMLHSTLSSAQQQSVFNIPPKGCRKIVLSTNIAETGVTIPDVTCVIDTGVHREMRY 993

  Fly   744 TSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSR----ARFQALEDNLTPEMFRTPLHE 804
            .|..:|:.....:.||.|.:||.||||||:.|.|:.|.|:    .:|.:.:   |||:.|..|.|
pombe   994 NSRRHLSRLTDTFVSKANAKQRSGRAGRVQEGICYHLFSKFKHDTQFLSYQ---TPEILRLNLQE 1055

  Fly   805 MALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLG 869
            :.|.:|:.::|.:...|.|||:||....:|.|...|.::..|..|::||.||:.|::||::..||
pombe  1056 VVLRVKMCQMGDVQDVLGKALDPPSSTNIIRALEKLHQVGALSENEKLTKLGKFLSQLPVDANLG 1120

  Fly   870 KMMVLGAVFGCAD----LMAIMASYSSTFSEVFSLDIGQRRLANHQK---ALSGTKCSDHVAMIV 927
            |::|||..:.|.|    ::|::     |....|...:.....||..:   |...|: ||.|.|..
pombe  1121 KILVLGCFYKCVDAASSIVAML-----TIGSPFRKSVDNEFSANKARLSFAKENTR-SDLVLMYY 1179

  Fly   928 ASQMWRR--EKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQ----------------- 973
            |...||.  ....|.. |..|...|.|.:..:::....|.|||..|:.
pombe  1180 AYCAWREICLSPLGPD-EDSFAKEKYLNLEALSMTESLKIQLLSELKDMKLLGASDVDTCKSLKR 1243

  Fly   974 ------AGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHK-EKRK--VLTTESKAA 1029
                  |..|:|    |:::   .|:..:|   ..::...|||||..:. |||:  .|:|..:..
pombe  1244 SICRRFAVIPKE----HDIN---SGNAEIL---CGVIAASLYPNILRYDYEKRQWSTLSTNKRVR 1298

  Fly  1030 LLHKTSVNCSNLAVTFPYPFFVFGEKI-RTRA---------VSCKQLSMVSPLQV---ILFGSRK 1081
            :| ..|||..:.....|..|..:...: .|||         |:.:||.|:..|:|   :..|..|
pombe  1299 IL-DVSVNNRSELPNMPSKFVAYTNMMSSTRASEYVNETTMVTLRQLLMMCGLKVENRVSVGQAK 1362

  Fly  1082 ID-----------LAANNIVR--VDNWLN-FDIEPE 1103
            :|           .|:.:|:|  ::..|| |..||:
pombe  1363 LDNFTVYFENVYVSASLSILRRFIETSLNEFFAEPD 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	14/87 (16%)
		DEXDc	393..569	CDD:214692	76/186 (41%)
		DEXDc	402..542	CDD:238005	64/150 (43%)
		ATP-synt_B	<584..644	CDD:304375	12/60 (20%)
		Helicase_C	643..772	CDD:278689	48/131 (37%)
		HA2	842..926	CDD:214852	27/90 (30%)
		OB_NTP_bind	974..1078	CDD:285018	31/119 (26%)
SPBC15C4.05	NP_595925.1	DEXDc	637..820	CDD:214692	77/189 (41%)
		DEXDc	650..793	CDD:238005	64/149 (43%)
		Helicase_C	891..1022	CDD:278689	47/130 (36%)
		HA2	1093..1177	CDD:214852	27/89 (30%)
		OB_NTP_bind	1218..1349	CDD:285018	33/141 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47184
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810