Protein Alignment mle and ucp12

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_588050.1
• Gene: ucp12 / 2539263
• PomBaseID: SPCC895.09C
• Length: 1327
• Species: Schizosaccharomyces pombe
• Alignment Length: 1069
• Identity: 287/1069 - (26%)
• Similarity: 469/1069 - (43%)
• Gaps: 213/1069 - (19%)

  Fly   153 EAFDVNAAIHGNWT------------IENAKERLNIYKQTNNIRDDYKYTPVGP------EHARS 199
            |:||.|.::..|.|            ::|...::   :....:|.||..:..|.      ..|||
pombe   388 ESFDGNISLEPNSTEWDDDVSALQSILDNKVSKI---ENGCRVRIDYPTSEFGELFVDFRRPARS 449

  Fly   200 FLAELSIYVPALNRTVTARESGSNKKSASK-----------SCALSLVRQLFHLNVIEPFSGTLK 253
            :.|    ::|.::.:.|.|.:...|.|..|           .|.||.
pombe   450 YPA----HIPLMSLSSTKRMASYIKLSILKKMVVYAMDLRGECMLSW------------------ 492

  Fly   254 KKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGE 318
                             |.|.:.|.|:.....:.:..||.....|      |:||..:.|....:
pombe   493 -----------------LYNHLQENIEDFLQNIGSLLNISAATIG------VSLSSQNKSAPTAK 534

  Fly   319 KRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREK 383
            |  .:|..|....::...:...||.....:.:.|       |:..:|:              |||
pombe   535 K--NNSFKPKLFRRSRELSEKLCNNWSERVKSPS-------YQLKVRE--------------REK 576

  Fly   384 LPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAIS 448
            ||....|.:|:.||..:.||:|.|.||.||:||:.|:|||.|:.||:.....:..||||||||||
pombe   577 LPAWESRRKIMDAIQHSQVVVISGETGSGKSTQVVQFILDHYLSSGEKDLQTVVCTQPRRISAIS 641

  Fly   449 VAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLE----AGLRGVSHIIVDEI 509
            :|||||.||...:|..|||||..|....:. ..:.|||.|:|||:::    ..|..:|.::|||:
pombe   642 LAERVAFERDTTVGKEVGYSVHGEKSISKE-TLLEFCTTGLLLRRIQQHGLGFLSTLSCVVVDEV 705

  Fly   510 HERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDI 574
            |||.:.:|.||.:|:.::...|:|.|||||||:::..|..|||....|.:.||.||::.:::|
pombe   706 HERSIENDILLTLLKLVISRIPNLKVILMSATVNSDTFKYYFGNAGHLHIHGRTFPIKDYYIE-- 768

  Fly   575 IQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFEL 639
                ||.|      |..|.:|||.:....|.|.||:|:.:     |:...:..|.|..|.
pombe   769 ----DFAP------KLNEDDDEEDVPRRKKKEYEIDYHLI-----SRLVSSIDAELGSSS----- 813

  Fly   640 LEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFE 704
                          |:|||||||.:.|...::.:::.    |.|::::||.|:.:...|||:.|:
pombe   814 --------------GSILVFLPGVSNIARCIREIKSK----DGSKFEVLPLHASLNTSEQRRCFK 860

  Fly   705 PVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRA 769
            ...:  .|||.:||||||||||||:|.|||..:.:...:....:|.::...|||:...:||:|||
pombe   861 TYTK--RKIICATNIAETSITIDDVVAVIDSGRVKQIDYDVERDLVTFKETWASRAACQQRRGRA 923

  Fly   770 GRVRPGFCFTLCSRA-RFQALEDNLTPEMFRTPLHEMALTI-----------KLLRLGSIHHFLS 822
            |||:.|.|:.|.:|. ..:.:.....||:.||.|.::.|.:           ..:..|||..|::
pombe   924 GRVKKGICYKLYTRGFEEKGMLGQTPPEVLRTALSQVCLNVVPLVKRFSSAGNSVNQGSIKKFMN 988

  Fly   823 KALEPPPVDAVIE-AEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAI 886
            ..::||. ||.:: |...|.::..|..:::||.||..|..|||:.:|||::|.|::||..:....
pombe   989 SLIDPPN-DATVDLALKKLIQVGALTVSEDLTGLGEYLVSLPIDLKLGKLLVFGSIFGYLEPALT 1052

  Fly   887 MASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKG 951
            :.:..||.|. |..|...|.:.:.|....|...:|  |.:..:.:...| .||.....::|:...
pombe  1053 ITAILSTKSP-FLGDDEAREIRSKQSQGWGDVLAD--ARVYHNWLEILE-TRGVKKTVQWCEEMH 1113

  Fly   952 LQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGD-----DPVLDVSLALLCLGLYPN 1011
            |..:|:..|...:.:|         .|...:.....:::.|:     ...|.|...|:...|.||
pombe  1114 LHYTTLQQIRQNRNEL---------SEAAQLLELTTKKLTGNFDWYSTENLTVLSTLIAAALSPN 1169

  Fly  1012 I--CVHKEKRKV------LTTESKAAL------------LHKTSVNCSNLAVTFPYPFFVFGEKI 1056
            :  ||:.:|:.|      |..|.:|.|            :|.:|....|........|..:.:|:
pombe  1170 VVKCVYPDKKFVASFSGSLEMEQEARLTKFYDQNNQRLFIHPSSTMFVNSPNASRCTFVAYEQKV 1234

  Fly  1057 RTRAVSCKQLSMVSPLQVILFGSRKI-------DLAANNIVRVDNWLNFDIEPELAAKIGALKPA 1114
            .|.....:..:.::...:||.|:..|       .|..:....:..|      |::...:..||..
pombe  1235 ETTKPFLRNCTPINTYGMILLGANDILIDPLGKGLILDQAYCIKAW------PKVVILLKMLKRC 1293

  Fly  1115 LEDLITVACDNPSDILRLEEPYAQLVKVV 1143
            |:..:....::.|. |..|....|.::.:
pombe  1294 LDASLHERLESSSG-LNYESEIHQCIRTL 1321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	18/90 (20%)
		DEXHc_DHX9	326..559	CDD:350730	89/236 (38%)
		HrpA	378..>889	CDD:441249	190/527 (36%)
		OB_NTP_bind	1002..1079	CDD:400182	20/96 (21%)
ucp12	NP_588050.1	UBA	277..312	CDD:395502
		RWD_YLR419W-like	403..505	CDD:467662	22/143 (15%)
		HrpA	575..>1138	CDD:441249	208/619 (34%)
		OB_NTP_bind	1158..1258	CDD:400182	21/99 (21%)