DRSC/TRiP Functional Genomics Resources

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Protein Alignment mle and Ythdc2

DIOPT Version :10

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_001156485.1 Gene:Ythdc2 / 240255 MGIID:2448561 Length:1445 Species:Mus musculus


Alignment Length:1368 Identity:402/1368 - (29%)
Similarity:572/1368 - (41%) Gaps:413/1368 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 PADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVID-RI 143
            |.....||||  ||..|.|..||.|      .|..||...|.         |.||....:.| ||
Mouse     9 PRPPAPSGGG--TGGGGGGSGGGGG------GGGGGPASCGP---------GGGGRAKGLKDIRI 56

  Fly   144 QEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYV 208
            .|          :|..|::      .|.||.....|.     :.::........|:|:..||   
Mouse    57 DE----------EVKIAVN------IALERFRYGDQR-----EMEFPSSLTSTERAFIHRLS--- 97

  Fly   209 PALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLIN 273
            .:|.....::..|:|:                :|.|         ||||.....:.: ::.||.:
Mouse    98 QSLGLVSKSKGKGANR----------------YLTV---------KKKDGSETAHAM-MTCNLTH 136

  Fly   274 KIDEVIKGL--DLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSV-------IPWA 329
            .....::.|  ..||.|....:         |:....|.:....:.|.|:.|..       ||..
Mouse   137 NTKHAVRSLIQRFPVTNKERTE---------LLPKTERGNVFAVEAENREMSKTSGRLNNGIPQV 192

  Fly   330 PPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEIL 394
            |            :..||                           .:|..||:.||:...:.||:
Mouse   193 P------------VKRGE---------------------------SEFDSFRQSLPVFEKQEEIV 218

  Fly   395 TAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCE 459
            ..|.:|.||:|.|.||.||||||.|::|||  |...|....|:.|||||::||:||||||.||.|
Mouse   219 KIIKENKVVLIVGETGSGKTTQIPQFLLDD--CFKNGIPCRIFCTQPRRLAAIAVAERVAAERRE 281

  Fly   460 QLGDTVGYSVRFES-VFPRPYGAILFCTVGVLLRKLEAG---LRGVSHIIVDEIHERDVNSDFLL 520
            ::|.|:||.:|.|| |.|:.  .:.|||.|||||.|.||   |..|:|:||||:||||..|||||
Mouse   282 RIGQTIGYQIRLESRVSPKT--LLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLL 344

  Fly   521 VILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMT------- 578
            ..|||::..:|.|.:||.||.:|...|.:|||.|||:.:.||.|.|::.|||||::.|       
Mouse   345 TKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEM 409

  Fly   579 --------------------------DFVPSAESRRKRKEVEDEEQLLSEDKD-------EAEIN 610
                                      .|.|.::.:|....|.:|..||.:..|       |.::|
Mouse   410 LKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVN 474

  Fly   611 -----------------------------------YNKVCEDKYSQKTRNAMAM----------- 629
                                               .|...:.::|:.:..|:.:           
Mouse   475 CLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVE 539

  Fly   630 ----------------------------------------------LSES--------DVSF--- 637
                                                          |.||        |:|.   
Mouse   540 QLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDR 604

  Fly   638 ELLEA-------------LLMHIKSKNI-----PGAILVFLPGWNLIFALM-KFLQNTNIFGD-T 682
            |||:|             |:||: ..||     .||||:||||::.|..|. :.|.:...|.| |
Mouse   605 ELLKAYHHSFDDEKVDLDLIMHL-LYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNT 668

  Fly   683 SQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHN 747
            .:||:...||.:...:|:||.:..|.||.||||||||||||||::|:|||||..|.:.|.|.:.|
Mouse   669 HRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALN 733

  Fly   748 NLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLL 812
            .:|....||.||.:..||||||||.|||.||.|.||.|||.:.:..|||:.|.||.|:.|..|||
Mouse   734 FVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLL 798

  Fly   813 R--LGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLG 875
            .  ..:|..||.||.||||...|..|..:|:.:..:||.::||.||..||.||:||.||||::..
Mouse   799 APVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCA 863

  Fly   876 AVFGCAD---LMAIMASYSSTFSEVFSLDIGQRRLAN--HQKALSGTKCSDHVAMIVASQMWRRE 935
            .|..|.|   .:|...:|...|  |......|:|.|.  .::..:|| .|||:|::.|.|.|  :
Mouse   864 VVLKCLDPILTIACTLAYRDPF--VLPTQASQKRAAMLCRKRFTAGT-FSDHMALLRAFQAW--Q 923

  Fly   936 KQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVS 1000
            |.|.:..|..||:...|..:||.:|...:.|||..|:.:||         |..|..||  :.||:
Mouse   924 KARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGF---------VRARGGGD--IRDVN 977

  Fly  1001 L---------ALLCLGLYPNICVHKEKRKVLTT--ESKAALLHKTSV------------NCSNLA 1042
            .         |.|..|:|||: ||.::..|:.|  :.|....|.|||            |....|
Mouse   978 TNSENWAVVKAALVAGMYPNL-VHVDRENVILTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAA 1041

  Fly  1043 V-TFPYPFFVFGEKIRT-RAVSCKQLSMVSPLQVILF-GSRKIDLAANNI--------------- 1089
            : ..|..:.::.|..|. |..:.:..|.|:|:.|::| |..:  ||:|.:               
Mouse  1042 IQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPAR--LASNALQEPSSFRADGIPNDS 1104

  Fly  1090 ---------------VRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQL 1139
                           :::|.||||.:|||.|:.:..|:.....|.......||      :|::|:
Mouse  1105 SDSEMEDRTTANLAALKLDEWLNFKLEPEAASLLLQLRQKWHSLFLRRMRAPS------KPWSQV 1163

  Fly  1140 ----VKVVKDLCVKSAGDFGLQRESGI-----------LP-------HQSR------QFSDGGGP 1176
                ::.:..:........|||:.|||           ||       :.||      :|:||...
Mouse  1164 DEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSTADTEFADGSTT 1228

  Fly  1177 PKR 1179
            .:|
Mouse  1229 GER 1231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM_DHX9_rpt1 2..70 CDD:380683
DSRM_DHX9_rpt2 167..241 CDD:380684 11/73 (15%)
DEXHc_DHX9 326..559 CDD:350730 102/236 (43%)
HrpA 378..>889 CDD:441249 248/682 (36%)
OB_NTP_bind 1002..1079 CDD:400182 26/93 (28%)
Ythdc2NP_001156485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50 19/57 (33%)
R3H_DEXH_helicase 61..119 CDD:100077 14/96 (15%)
PRK11131 203..>1033 CDD:182986 299/851 (35%)
DEXHc_YTHDC2 208..383 CDD:350745 94/178 (53%)
DEAH box 331..334 2/2 (100%)
ANK repeat 520..552 CDD:293786 1/31 (3%)
ANK 1 521..553 1/31 (3%)
ANK 2 554..586 0/31 (0%)
ANK repeat 554..582 CDD:293786 0/27 (0%)
SF2_C_RHA 612..767 CDD:350178 71/155 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1303 14/53 (26%)
YTH 1304..1433 CDD:410979
Blue background indicates that the domain is not in the aligned region.

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