DRSC/TRiP Functional Genomics Resources

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Protein Alignment mle and DHX30

DIOPT Version :9

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:XP_011531792.1 Gene:DHX30 / 22907 HGNCID:16716 Length:1265 Species:Homo sapiens


Alignment Length:1303 Identity:368/1303 - (28%)
Similarity:577/1303 - (44%) Gaps:355/1303 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 IRQTGPKNRQ-----RFLCEVRVEPNTYIGVGNSTNKKDAEKN----ACRDFVNYLVRVGKLNTN 77
            :...|||.::     ::...|.||       |..:.|.|||:.    ||:.|..:    |.|   
Human   148 VHTNGPKKKKVTLHIKWPKSVEVE-------GYGSKKIDAERQAAAAACQLFKGW----GLL--- 198

  Fly    78 DVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSG-PQDL---------GEAYRPLNHD--- 129
                       |||..|..|.       :.||...:.| |.|.         ..::|.||.:   
Human   199 -----------GPRNELFDAA-------KYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPESIR 245

  Fly   130 -GGDGGNRYSVIDRIQEQRDMNEAE---------------------------AF---DVNAAIHG 163
             ||.||...| :.|.:|:.:..|.|                           :|   |.::||..
Human   246 PGGPGGLSRS-LGREEEEDEEEELEEGTIDVTDFLSMTQQDSHAPLRDSRGSSFEMTDDDSAIRA 309

  Fly   164 NWTIENAKERL----NIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNK 224
            .......|..|    .|...::..::..::..||   .::.|:.|::..|.   .:|....|..|
Human   310 LTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVG---TKTKLSTLTLLWPC---PMTFVAKGRRK 368

  Fly   225 KSASKSCALSLVRQLFHLNVI----EPFS------GTLKKKKDEQLKP----------------- 262
            ..|....|....::|..|.::    ||.:      .:|::..:.|.:|                 
Human   369 AEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIETFL 433

  Fly   263 --YPVK---LSPNLINKIDEVIK-GLDL-PVVNPRNIKIELDGPP-IPLI----VNLSR--IDSS 313
              |||:   ::|.|..:.|:::. |.|. |:.:|      :.|.| :||:    |.||:  ::..
Human   434 NHYPVESSWIAPELRLQSDDILPLGKDSGPLSDP------ITGKPYVPLLEAEEVRLSQSLLELW 492

  Fly   314 QQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFL 378
            ::.|...||:       ||                                              
Human   493 RRRGPVWQEA-------PQ---------------------------------------------- 504

  Fly   379 EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRR 443
                 ||:...|..||.||..:|||:|.|:|||||||:|.|.:|:.|:..|:|...|:.:|||||
Human   505 -----LPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRR 564

  Fly   444 ISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEA--GLRGVSHIIV 506
            |||:|||:||:.|....|...||:.||.||..|...||:||||||:|||||::  .|.||||:||
Human   565 ISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIV 629

  Fly   507 DEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFL 571
            ||:||||||:||||::|:.:....|.|.::|||||.|..:||:|||.|||::|||..:||::.:|
Human   630 DEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYL 694

  Fly   572 EDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVS 636
            |||:.                                    |:.:.:|..:.|:..:. .|..:.
Human   695 EDILA------------------------------------KLGKHQYLHRHRHHESE-DECALD 722

  Fly   637 FELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRK 701
            .:|:..|::||.::..||.||.|||||..|..:.:.||.. :....|:|.|||.||.||..:|:.
Human   723 LDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEA-LGMHESKYLILPVHSNIPMMDQKA 786

  Fly   702 VFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRK 766
            :|:..|.||.||:|:||||||||||:|||.|:|....:.:.:.....::...|||.|:.|:.||:
Human   787 IFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRR 851

  Fly   767 GRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIH-------HFLSKA 824
            |||||.:.||.:.|..|:|.:.:.....||:.||||..:.|..|      ||       .|||||
Human   852 GRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAK------IHMPEKTAVEFLSKA 910

  Fly   825 LEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMAS 889
            ::.|.:.||.||.:||:|:..||..:.||.||:.||.:..:|||.|.:||.|:|.|  |..::..
Human   911 VDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRC--LHPLLVV 973

  Fly   890 YSSTFSEVFSLDIGQRRLANHQKA-LSGTKCSDHVAMIVASQ------MWRREKQRGEHMEARFC 947
            .|....:.||..:..|...:..|| ||....|||:|.:.|..      .|:....|..::|... 
Human   974 VSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENL- 1037

  Fly   948 DWKGLQMSTMNVIWDAKQQLLDLLQQA---GFPEEC-MISHEVDERIDGDDPVLDVSLALLCLGL 1008
                |...::..|....:|..:.:.:|   |.|.:| :.|.:.:|..:.::.|..|.:|    ||
Human  1038 ----LYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEEELVKGVLMA----GL 1094

  Fly  1009 YPNICVHKEKRKV------------LTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTR-- 1059
            |||: :...:.||            ..|:|...||||:::|..             ..::|:|  
Human  1095 YPNL-IQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINRE-------------ATRLRSRWL 1145

  Fly  1060 ----------AVSCKQLSMVSPLQVILF----------GSR-KIDLAANNIVRVD---------- 1093
                      :|..:..|.|.||.|:|.          |.| .|.|:.::::|::          
Human  1146 TYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLK 1210

  Fly  1094 ---NWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAGDFG 1155
               ..|...:|..|.:::.||.|:                 ::|.:.||:.::.:|.....|.|.
Human  1211 ELRRALGRMVERSLRSELAALPPS-----------------VQEEHGQLLALLAELLRGPCGSFD 1258

  Fly  1156 LQR 1158
            :::
Human  1259 VRK 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM 4..68 CDD:214634 14/54 (26%)
DSRM 170..240 CDD:214634 13/73 (18%)
DEXDc 393..569 CDD:214692 99/177 (56%)
DEXDc 402..542 CDD:238005 79/141 (56%)
ATP-synt_B <584..644 CDD:304375 5/59 (8%)
Helicase_C 643..772 CDD:278689 58/128 (45%)
HA2 842..926 CDD:214852 31/84 (37%)
OB_NTP_bind 974..1078 CDD:285018 32/141 (23%)
DHX30XP_011531792.1 HrpA 494..>1143 CDD:224557 264/775 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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