DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx29

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_766182.2	Gene:	Dhx29 / 218629	MGIID:	2145374	Length:	1365	Species:	Mus musculus

Alignment Length:	1178	Identity:	357/1178 - (30%)
Similarity:	573/1178 - (48%)	Gaps:	224/1178 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 RIQEQRD----------MNEAEAFDVN------AAIHGNWTIENAKERLNIYKQTNNIRDDYKYT 190
            |..||:|          :.|.|.||.|      ||     .:.:|||:...:|...|.:...:
Mouse   233 RYAEQQDEEEKGEGSKGLEEEEKFDPNQRYLNLAA-----RLLDAKEQAAAFKLEKNKQGQKE-- 290

  Fly   191 PVGPEHARSFLAELS------IYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFS 249
              ..|..|.|..|:.      |:.||:.   .:.:....||.|..:.|.|.:    :||:.|..:
Mouse   291 --AQEKIRKFQREMETLEDHPIFNPAIK---ISHQQNEKKKPAPATEAESAL----NLNLFEKSA 346

  Fly   250 GTLKKKKDEQLKPYPVK---------------------------LSPN----------------- 270
            ...:::|.::.:|:.|:                           .|||
Mouse   347 AATEEEKGKKKEPHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVAVGRYWKCRVR 411

  Fly   271 LINKIDEV---------------------------IKGLDLPVVNP---RNI------------- 292
            ::...|:|                           :||..:..:.|   |::
Mouse   412 VVRSEDDVLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWSDEEKKREE 476

  Fly   293 --KIELDGPP---IPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELAT-- 350
              |:|.:.|.   |..::|..: ...||..::|.||.......|:.:|...    :.:.:||.
Mouse   477 LNKMETNKPRDLFIAKLLNKLK-QQQQQQQQQRPESEKGGSEDPEESWENL----VSDEDLAALS 536

  Fly   351 ---TSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCG 412
               ||.:||:.  .|||..|.|:..:|::.|:.|::||:...|..|:..:..:.||::.|.||.|
Mouse   537 LEPTSAEDLAP--VRSLFRRLQSTPKYQRLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSG 599

  Fly   413 KTTQIAQYILDDYICSGQGG-YANIYVTQPRRISAISVAERVARERCEQLG---------DTVGY 467
            |:||:..::|:|.:....|. ..||..||||||||:|:|.||    ||:||         ...||
Mouse   600 KSTQVPHFLLEDLLLDECGARKCNIVCTQPRRISAVSLATRV----CEELGCESGPGGRNSLCGY 660

  Fly   468 SVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTY 530
            .:|.||..... ..:|:||.|||||||:..  |..|||:||||:|||.|.||||||||::::...
Mouse   661 QIRMESRASES-TRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKR 724

  Fly   531 PDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVED 595
            .|||:||||||:|:.|||.||..||:|.:.||::||:.|.||||::.|.||...:|...:|.:|:
Mouse   725 SDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHLEDIVEETGFVLEKDSEYCQKFLEE 789

  Fly   596 EEQLLSEDKDEA------------------EIN--YNKVCEDKYSQKTRNAMAMLSESDVSFELL 640
            ||::......:|                  |:|  |     .|||.:|::|:..::...::.:|:
Mouse   790 EEEITINVTSKAGGVKKYQEYIPVQSGASPELNPFY-----QKYSSRTQHAILYMNPHKINLDLI 849

  Fly   641 EALLMHI-KS---KNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRK 701
            ..||::: ||   :||.||:|:||||...|..|...|.:...| .:.:||::..||.:...:|..
Mouse   850 LELLVYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSSDRRF-YSERYQVIALHSVLSTQDQAA 913

  Fly   702 VFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRK 766
            .|...|.||.||:|:||||||.|||.|:|||||..:.:...:...:.::|....:.||.:..||:
Mouse   914 AFMFPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQ 978

  Fly   767 GRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVD 831
            |||||||.||||.|.:|.||:...|...||:.|.||.|:.|.|....|||...||||||:||.:.
Mouse   979 GRAGRVRDGFCFRLYTRERFEGFLDYSVPEILRVPLEELCLHIMKCDLGSPEDFLSKALDPPQLQ 1043

  Fly   832 AVIEAEVLLREMRCLDAND-ELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFS 895
            .:..|..|||::...:.|: :|||||:.||.||:..::|||::.||:|||.:.:|.:|:. .|..
Mouse  1044 VISNAMNLLRKIGACEPNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAV-MTEK 1107

  Fly   896 EVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGE-HMEARFCDWKGLQMSTMNV 959
            ..|...||::..|:..|:......|||:.:..|...|::.:|.|. ..|..:|....|..:::..
Mouse  1108 SPFITPIGRKDEADLAKSSLAVADSDHLTIYNAYLGWKKAQQEGGFRSEISYCQRNFLNRTSLLT 1172

  Fly   960 IWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPV--LDVSL--ALLCLGLYPNICVHKEKRK 1020
            :.|.||:|:.|::.|||.     |....|...|...:  .|::|  |:|..|||.::......:.
Mouse  1173 LEDVKQELMKLVKAAGFS-----SSPSWEGRKGPQTLSFQDIALLKAVLAAGLYDSVGKIMCTKS 1232

  Fly  1021 VLTTESKA---------ALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVIL 1076
            |..||..|         |.:|.:||| .:|..   |.:.::.||:|...|..::.::::|..|:|
Mouse  1233 VDVTEKLACMVETAQGKAQVHPSSVN-RDLQT---YGWLLYQEKVRYTRVYLRETTLITPFPVLL 1293

  Fly  1077 FGSRKIDLAANN---IVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQ 1138
            ||.   |:...:   ::.||.|:.|....::|.....|:..::.::....:||.  :.||..  :
Mouse  1294 FGG---DIEVQHRERLLSVDGWIYFQAPVKIAVIFKQLRVLIDSVLRKKLENPK--MSLEND--K 1351

  Fly  1139 LVKVVKDL 1146
            :::::.:|
Mouse  1352 ILQIITEL 1359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	17/75 (23%)
		DEXDc	393..569	CDD:214692	88/187 (47%)
		DEXDc	402..542	CDD:238005	73/151 (48%)
		ATP-synt_B	<584..644	CDD:304375	15/79 (19%)
		Helicase_C	643..772	CDD:278689	53/132 (40%)
		HA2	842..926	CDD:214852	29/84 (35%)
		OB_NTP_bind	974..1078	CDD:285018	31/116 (27%)
Dhx29	NP_766182.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..257		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..524		6/23 (26%)
		DEXDc	577..763	CDD:214692	89/190 (47%)
		DEXDc	588..735	CDD:238005	72/151 (48%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	701..704		2/2 (100%)
		Helicase_C	863..984	CDD:278689	49/121 (40%)
		HA2	1055..1136	CDD:214852	29/81 (36%)
		OB_NTP_bind	1178..1298	CDD:285018	36/131 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820