Protein Alignment mle and Dhx8

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_659080.2
• Gene: Dhx8 / 217207
• MGIID: 1306823
• Length: 1244
• Species: Mus musculus
• Alignment Length: 973
• Identity: 251/973 - (25%)
• Similarity: 423/973 - (43%)
• Gaps: 207/973 - (21%)

  Fly   169 NAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCAL 233
            |...|.|:..:||  .:.....|..|.|. |.::...:...:|.|....|.|...|..
Mouse   371 NPNRRRNLVGETN--EETSMRNPDRPTHL-SLVSAPEVEDDSLERKRLTRISDPEKWE------- 425

  Fly   234 SLVRQLFHLNVI--EPF------SGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPR 290
              ::|:...||:  |.|      :|.|.|..||:.:...::    |:.:....::|
Mouse   426 --IKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIE----LVEEEPPFLRG--------- 475

  Fly   291 NIKIELDGPPIPLIVN----LSRIDSSQ----------QDGEKRQESSVIP------WAPPQANW 335
            :.|..:|..||.::.|    ||:....|          :..::..|...||      |..|..:
Mouse   476 HTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPD- 539

  Fly   336 NTWHACNIDEGELATTSIDDLSMDYERSLRDRRQND-NEYRQ-----------------FLEFRE 382
                    .||.....::..:.|         ..|| .|:::                 .||.||
Mouse   540 --------AEGRQIAANMRGIGM---------MPNDIPEWKKHAFGGNKASYGKKTQMSILEQRE 587

  Fly   383 KLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN---IYVTQPRRI 444
            .|||..::.:::.|::||.::|:.|.||.||||||.||:       .:.||.:   |..|||||:
Mouse   588 SLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYL-------AEAGYTSRGKIGCTQPRRV 645

  Fly   445 SAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVD 507
            :|:|||:||:.|....||..|||::|||.. ..|...|.:.|.|:|||:  ::..|...:.|::|
Mouse   646 AAMSVAKRVSEEFGCCLGQEVGYTIRFEDC-TSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLD 709

  Fly   508 EIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLE 572
            |.|||.:::|.|..:|:..|....|:.:|:.|||:|..|||:||...|:..:|||.:||
Mouse   710 EAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPV------ 768

  Fly   573 DIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSF 637
                                               ||.|.|..|..|               :..
Mouse   769 -----------------------------------EILYTKEPETDY---------------LDA 783

  Fly   638 ELLEALLMHIKSKNIPGAILVFLPG-------WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIP 695
            .|:..:.:|:...  ||.|||||.|       ..:::..||     ::..|..:..|||.:|.:|
Mouse   784 SLITVMQIHLTEP--PGDILVFLTGQEEIDTACEILYERMK-----SLGPDVPELIILPVYSALP 841

  Fly   696 RDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKT 760
            .:.|.::|:|.|.|..|::::|||||||:|||.|.:|:|....:.|::.|...:........|:.
Mouse   842 SEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQA 906

  Fly   761 NLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLT---PEMFRTPLHEMALTIKLLRLGSIHHFLS 822
            ..:||.|||||..||.|:.|.:...::  ::.||   ||:.||.|....|::|.:.:..:..|
Mouse   907 QAKQRAGRAGRTGPGKCYRLYTERAYR--DEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSF-- 967

  Fly   823 KALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIM 887
            ..::.||::.:|.|...|..:..||....||.|||.:|..|:||.|.||:::....||::.|..:
Mouse   968 DFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTI 1032

  Fly   888 ASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGL 952
            .|..|. ..||.....::.||:.:||.......||:.::.....|:..|     ....:|....:
Mouse  1033 VSMLSV-QNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNK-----FSNPWCYENFI 1091

  Fly   953 QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKE 1017
            |..::....|.::|:|.::.:          |::|....|...| .|..| :|.|.:.| ...|:
Mouse  1092 QARSLRRAQDIRKQMLGIMDR----------HKLDVVSCGKSTV-RVQKA-ICSGFFRN-AAKKD 1143

  Fly  1018 KRKVLTT--ESKAALLHKTSVNCSNLAVTFPYP-FFVFGEKIRTRAVSCKQLSMVSPLQVILF 1077
            .::...|  :.:...:|.:|      |:....| :.|:.|.:.|.....::::.:.|..::.|
Mouse  1144 PQEGYRTLIDQQVVYIHPSS------ALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEF 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	15/71 (21%)
		DEXHc_DHX9	326..559	CDD:350730	85/261 (33%)
		HrpA	378..>889	CDD:441249	169/525 (32%)
		OB_NTP_bind	1002..1079	CDD:400182	15/79 (19%)
Dhx8	NP_659080.2	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..289
		S1_DHX8_helicase	289..367	CDD:240189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..396		7/26 (27%)
		HrpA	580..>1211	CDD:441249	206/721 (29%)
		DEAH box	709..712		2/2 (100%)