DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx8

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_659080.2	Gene:	Dhx8 / 217207	MGIID:	1306823	Length:	1244	Species:	Mus musculus

Alignment Length:	973	Identity:	251/973 - (25%)
Similarity:	423/973 - (43%)	Gaps:	207/973 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 NAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCAL 233
            |...|.|:..:||  .:.....|..|.|. |.::...:...:|.|....|.|...|..
Mouse   371 NPNRRRNLVGETN--EETSMRNPDRPTHL-SLVSAPEVEDDSLERKRLTRISDPEKWE------- 425

  Fly   234 SLVRQLFHLNVI--EPF------SGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPR 290
              ::|:...||:  |.|      :|.|.|..||:.:...::    |:.:....::|
Mouse   426 --IKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIE----LVEEEPPFLRG--------- 475

  Fly   291 NIKIELDGPPIPLIVN----LSRIDSSQ----------QDGEKRQESSVIP------WAPPQANW 335
            :.|..:|..||.::.|    ||:....|          :..::..|...||      |..|..:
Mouse   476 HTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPD- 539

  Fly   336 NTWHACNIDEGELATTSIDDLSMDYERSLRDRRQND-NEYRQ-----------------FLEFRE 382
                    .||.....::..:.|         ..|| .|:::                 .||.||
Mouse   540 --------AEGRQIAANMRGIGM---------MPNDIPEWKKHAFGGNKASYGKKTQMSILEQRE 587

  Fly   383 KLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN---IYVTQPRRI 444
            .|||..::.:::.|::||.::|:.|.||.||||||.||:       .:.||.:   |..|||||:
Mouse   588 SLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYL-------AEAGYTSRGKIGCTQPRRV 645

  Fly   445 SAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVD 507
            :|:|||:||:.|....||..|||::|||.. ..|...|.:.|.|:|||:  ::..|...:.|::|
Mouse   646 AAMSVAKRVSEEFGCCLGQEVGYTIRFEDC-TSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLD 709

  Fly   508 EIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLE 572
            |.|||.:::|.|..:|:..|....|:.:|:.|||:|..|||:||...|:..:|||.:||
Mouse   710 EAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPV------ 768

  Fly   573 DIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSF 637
                                               ||.|.|..|..|               :..
Mouse   769 -----------------------------------EILYTKEPETDY---------------LDA 783

  Fly   638 ELLEALLMHIKSKNIPGAILVFLPG-------WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIP 695
            .|:..:.:|:...  ||.|||||.|       ..:::..||     ::..|..:..|||.:|.:|
Mouse   784 SLITVMQIHLTEP--PGDILVFLTGQEEIDTACEILYERMK-----SLGPDVPELIILPVYSALP 841

  Fly   696 RDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKT 760
            .:.|.::|:|.|.|..|::::|||||||:|||.|.:|:|....:.|::.|...:........|:.
Mouse   842 SEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQA 906

  Fly   761 NLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLT---PEMFRTPLHEMALTIKLLRLGSIHHFLS 822
            ..:||.|||||..||.|:.|.:...::  ::.||   ||:.||.|....|::|.:.:..:..|
Mouse   907 QAKQRAGRAGRTGPGKCYRLYTERAYR--DEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSF-- 967

  Fly   823 KALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIM 887
            ..::.||::.:|.|...|..:..||....||.|||.:|..|:||.|.||:::....||::.|..:
Mouse   968 DFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTI 1032

  Fly   888 ASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGL 952
            .|..|. ..||.....::.||:.:||.......||:.::.....|:..|     ....:|....:
Mouse  1033 VSMLSV-QNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNK-----FSNPWCYENFI 1091

  Fly   953 QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKE 1017
            |..::....|.::|:|.::.:          |::|....|...| .|..| :|.|.:.| ...|:
Mouse  1092 QARSLRRAQDIRKQMLGIMDR----------HKLDVVSCGKSTV-RVQKA-ICSGFFRN-AAKKD 1143

  Fly  1018 KRKVLTT--ESKAALLHKTSVNCSNLAVTFPYP-FFVFGEKIRTRAVSCKQLSMVSPLQVILF 1077
            .::...|  :.:...:|.:|      |:....| :.|:.|.:.|.....::::.:.|..::.|
Mouse  1144 PQEGYRTLIDQQVVYIHPSS------ALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEF 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	14/69 (20%)
		DEXDc	393..569	CDD:214692	73/180 (41%)
		DEXDc	402..542	CDD:238005	57/144 (40%)
		ATP-synt_B	<584..644	CDD:304375	7/59 (12%)
		Helicase_C	643..772	CDD:278689	45/135 (33%)
		HA2	842..926	CDD:214852	27/83 (33%)
		OB_NTP_bind	974..1078	CDD:285018	20/107 (19%)
Dhx8	NP_659080.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..289
		S1_DHX8_helicase	289..367	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..396		7/26 (27%)
		DEXDc	585..770	CDD:214692	78/233 (33%)
		DEXDc	606..744	CDD:238005	57/145 (39%)
		DEAH box	709..712		2/2 (100%)
		HELICc	769..926	CDD:238034	56/178 (31%)
		HA2	988..1070	CDD:214852	27/82 (33%)
		OB_NTP_bind	1104..1203	CDD:285018	22/116 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810