Protein Alignment mle and Dhx37

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_017176254.1
• Gene: Dhx37 / 208144
• MGIID: 3028576
• Length: 1161
• Species: Mus musculus
• Alignment Length: 825
• Identity: 217/825 - (26%)
• Similarity: 347/825 - (42%)
• Gaps: 195/825 - (23%)

  Fly   372 NEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN- 435
            |...:..|.|.||||.|....|:.|:.::|:||:.|.||.|||||:.|::.       :.||::
Mouse   236 NRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLY-------EAGYSSE 293

  Fly   436 ---IYVTQPRRISAISVAERVARERCEQLGD-TVGYSVRFESVFPRPYGAILFCTVGVLLRKLEA 496
               |.||:|||::|:::::|||:|.  .|.. .|.|.:|:|...... ..|.|.|.||||::::.
Mouse   294 DSIIGVTEPRRVAAVAMSQRVAKEM--NLSHRVVSYQIRYEGNVTEE-TRIKFMTDGVLLKEIQK 355

  Fly   497 GLRGVSH--IIVDEIHERDVNSDFLLVILRDMV----DTYPDLHVILMSATI---DTTKFSKYFG 552
            ....:.:  :|:||.|||.|.:|.||.:|..:|    ..:..|.:::||||:   |.|:..:.|.
Mouse   356 DFLLLKYKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFT 420

  Fly   553 I-CPVLEVPGRAFPVQQFF-----LED--------IIQMTDFVPS--------------AESRRK 589
            . .||::|..|.|||...|     |:|        :.::...:|:              |..||.
Mouse   421 TPPPVIKVESRQFPVTVHFNKRTPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRL 485

  Fly   590 RKEVE---DEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAML----------------SESDV 635
            ||...   .:.|...||..|....:.     |...:.|.|.||.                .:.|.
Mouse   486 RKAFPFRCSQPQEKEEDSAEGMRRFK-----KSRTRARKAQAMALPQINLDNYSVLPAGEGDEDR 545

  Fly   636 SFEL---LEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTS-QYQILPCHSQIPR 696
            ..|:   .|||                  |.:|...|.....|.....|.| ...:||.:|.:..
Mouse   546 EAEMDDEEEAL------------------GSDLDLDLGDSEANEGEQPDASLPLHVLPLYSLLAP 592

  Fly   697 DEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTN 761
            ::|.:||:|.|||....:::||:||||:||..|.:|:|..|.:.:.:.....::|:...|.|:.:
Mouse   593 EKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQAS 657

  Fly   762 LEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALE 826
            .:||.|||||..||.|:.|.|.|.|...|....||:.|.|:.::.|.:|.|.:..:.:|....
Mouse   658 ADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALSIEKVINFPFPT-- 720

  Fly   827 PPPVDAVIEAEVLLREMRCLDANDE---------------LTPLGRLLARLPIEPRLGKMMVLGA 876
            ||.|:|::.||.||..:..|.|..:               :|.|||.::..|:.||..||:.|..
Mouse   721 PPSVEALVAAEELLVALGALQAPPKQERMKKLQMSQLSCPITALGRTMSTFPVAPRYAKMLALSQ 785

  Fly   877 VFGCAD-LMAIMASYSSTFSEVF-SLD---IGQRRLANHQKALSGTKCSDHVAMIVASQMWRREK 936
            ..||.. .:||:|  :.|..|:| .||   ..::.||.    |.|.:..       .:||.|...
Mouse   786 QHGCLPYTIAIVA--AMTVRELFEELDRPAASEKELAE----LKGRRAR-------VAQMKRTWA 837

  Fly   937 QRGEHME--------------------ARFCDWKGLQMSTMNVIWDAKQQLLDLLQ----QAGF- 976
            .:|..::                    .:||...||:...|..|...:.||...:.    :||.
Mouse   838 GQGPSLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTAVNAVCPEAGLF 902

  Fly   977 -------PEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAA----- 1029
                   |.|..:::               ...::..||..::....:...:|..:.|.|
Mouse   903 LDPKMQPPTESQVTY---------------LRQIMAAGLGDHLARRVQSEDLLDPKWKNAYKTPL 952

  Fly  1030 -----LLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMV 1069
                 .:|.:||....|.     .|.|:.|.:.|..:..|.:|.|
Mouse   953 LDDPVFIHPSSVLFKELP-----EFVVYQEIVETTKMYMKGVSTV 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	69/201 (34%)
		HrpA	378..>889	CDD:441249	174/591 (29%)
		OB_NTP_bind	1002..1079	CDD:400182	16/78 (21%)
Dhx37	XP_017176254.1	HrpA	248..>1036	CDD:441249	213/813 (26%)