DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mle and smgl-2

DIOPT Version :10

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_001294374.1 Gene:smgl-2 / 177135 WormBaseID:WBGene00021365 Length:1089 Species:Caenorhabditis elegans


Alignment Length:919 Identity:250/919 - (27%)
Similarity:388/919 - (42%) Gaps:224/919 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   366 DRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQ 430
            ::.|...:.::..:.:::||||....||:..:..|.|:|:.|:|||||:||:.||:|       :
 Worm   126 NQHQKFQKLQKLRKLQKELPIAERAGEIVELLKTNQVLIVAGDTGCGKSTQVPQYLL-------K 183

  Fly   431 GGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLE 495
            .|:..:..||||||:..::|.|||.|...|.|..|.:.:|||:...:. ..:||.|.|:|||::|
 Worm   184 AGFTGVACTQPRRIACTALARRVAYETLNQYGSEVAFQIRFETTKSQK-TKLLFLTEGLLLRQME 247

  Fly   496 AG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLE 558
            ..  |...:.||:||:|||.:.||.|:.:|||:.....||.:|||||||:...|..||...||::
 Worm   248 KDSLLEKYNVIILDEVHERHLTSDLLIGLLRDLCTKRDDLKLILMSATINLDLFKGYFEGAPVVQ 312

  Fly   559 VPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCE--DKYSQ 621
            ||||.||:...: ..|.|..|     :|.:|..:::.|.             |.|:.|  ||...
 Worm   313 VPGRLFPIDVRW-HPIKQFID-----QSDKKTHKIDPEP-------------YLKILELIDKQFP 358

  Fly   622 KTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGD-TSQY 685
            .|:.                            |..|:||.|...|..:.:.|:|   :.: |:.:
 Worm   359 STQR----------------------------GDALIFLNGVAEISMVAEHLKN---YAELTNGW 392

  Fly   686 QILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARM---KLFTSHN 747
            .||..||.:..:||.|||:..|.|:.|.|||||:||||:|||.|.||||..|..:   :..|...
 Worm   393 IILMLHSTLSVEEQDKVFDQAPVGIRKCILSTNVAETSVTIDGIRFVIDSGKVNLIKHEPGTGTQ 457

  Fly   748 NLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLL 812
            .||.:   |.||.:..||||||||..||.|:.|.|:.:|:.::|....|:.|..|.||||.:..|
 Worm   458 KLTEF---WVSKASANQRKGRAGRTGPGICYRLYSQEQFEKMDDFTVSEINRVSLQEMALKMISL 519

  Fly   813 RLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCL--DAND--ELTPLGRLLARLPIEPRLGKMMV 873
            .|| :.......:|.|..|.:.|...:|:..|.|  |..|  .||.||.::::||:|..:.||:|
 Worm   520 NLG-LDPRTFPFIEKPSEDVLNEGLEVLKFQRVLRSDRGDILTLTALGNMVSKLPVEVPIAKMLV 583

  Fly   874 LGAVFGCADLMAIMA---SYSSTFS--EVFSLDIGQRRLANH------------------QKALS 915
            .|.|....::|..:|   |..|.|:  ....|:|.:||.:..                  |||..
 Worm   584 YGCVVDELEVMLTVAAGLSVQSPFTNRSYRELEIVERRASLTSPLGDPFTLISIFREWVLQKAFE 648

  Fly   916 GTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDA----------------- 963
            ||           ::.|..|....||   |..:...|:.....::.||                 
 Worm   649 GT-----------ARRWTMENGIDEH---RLYEISKLRAQYRQILEDAGLVEKASAAETGEDDSR 699

  Fly   964 --------KQQLLDL------------LQQAGFPEECMISHEVDERIDGD-DPV----------- 996
                    |::|.||            :..|....:.::..:.:|.::.: ||:           
 Worm   700 QRRIDQGEKRKLFDLKKSQRNNDRRQKVLNANKHFDKILEDKEEEDLEAEKDPLKADVKTVEFLL 764

  Fly   997 --------------------LDVSLALLCLGLYPNICVHKEKRKV-----------------LTT 1024
                                .:|...::..|||||..:.....|.                 :..
 Worm   765 SHKQRDVENIRKTHKISRKTAEVVRVIIAAGLYPNFSILDPVNKYGYGQEMFTHTRLKPFTQIHP 829

  Fly  1025 ESKAALLHKTSVN----CSNLAVTFPYPFFVFGEKIR-TRAVSCKQLSMVSPLQVILFGSRKIDL 1084
            .|..|..|..:::    ....:.....||  :|..:. |:...|.    |.|:..:.     ..|
 Worm   830 NSSIAQYHPETIDPRQGSDGFSRLHQIPF--YGLLLETTKPYICN----VMPVPAVY-----TLL 883

  Fly  1085 AANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVK 1149
            .|..||..|:|....|:..|..:..:           :.|..|.:|..:|...:|.|.:....|.
 Worm   884 VAQKIVIEDDWSQLSIDDFLELRFRS-----------STDCRSVLLDAKEIRYELTKGLAAKLVG 937

  Fly  1150 SAGDFGLQR 1158
            .||..|.:|
 Worm   938 EAGFSGRRR 946

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM_DHX9_rpt1 2..70 CDD:380683
DSRM_DHX9_rpt2 167..241 CDD:380684
DEXHc_DHX9 326..559 CDD:350730 75/194 (39%)
HrpA 378..>889 CDD:441249 185/525 (35%)
OB_NTP_bind 1002..1079 CDD:400182 16/98 (16%)
smgl-2NP_001294374.1 HrpA 143..>694 CDD:441249 205/626 (33%)
OB_NTP_bind 788..888 CDD:400182 18/110 (16%)
Blue background indicates that the domain is not in the aligned region.

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