Protein Alignment mle and mog-1

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_499212.1
• Gene: mog-1 / 176409
• WormBaseID: WBGene00003389
• Length: 1131
• Species: Caenorhabditis elegans
• Alignment Length: 1066
• Identity: 280/1066 - (26%)
• Similarity: 461/1066 - (43%)
• Gaps: 208/1066 - (19%)

  Fly    73 KLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRY 137
            |.|:.|:|.        ||          |...:||..|.:   :.:..|:|....:..|...|.
 Worm   150 KRNSWDMPT--------PR----------GERDRKRYMDSE---RSISSAWRSERRNRDDEKRRR 193

  Fly   138 SVIDRIQEQ--RDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNI-RDDYKYTPVGPEHARS 199
               .|..|.  |.:.|.:|         ..|..:.:||....::..|: |:.|       ::..:
 Worm   194 ---HRKPEDSVRSVKEEKA---------EPTFHDDEERAQWEEEQKNLDREWY-------DNEGA 239

  Fly   200 FLAELSIYVPALNRTVTARESGSNKKSAS-----KSCALSLVRQLFHLN---------VIEPFSG 250
            |..|.:.:....:..|..||....:|:..     |..|:....:|:..|         :.:..|.
 Worm   240 FDDEYNPFNKVSDEFVEKREKQWQEKTQKPRLTVKQQAIKRENELWENNRLHRSGVVAMADELSS 304

  Fly   251 TLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLI-------VNLS 308
            ..:.:.||              |::..:::.:..|.::.|.:..:...|.||::       |:.:
 Worm   305 IFEDETDE--------------NRVTILVQNIVPPFLDGRIVFTKQAQPIIPVVDTTCDMAVSAA 355

  Fly   309 R---IDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLR-DRRQ 369
            |   ....:::.|.|:::....|....:...........:.|.|....|| |.:|:.|.: ....
 Worm   356 RGSVAVRKRREVEDRKKAQDKHWELAGSKLGNLMGVKEKKDETADPEDDD-SGNYKESHQFASHM 419

  Fly   370 NDNE-------YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYIC 427
            .|||       .:...:.||.||:.|.|.:::..|.:|.||||.|.||.|||||:|||:|:|
 Worm   420 KDNEAVSDFAMEKSIKQQREYLPVFACRQKMMNVIRENNVVIIVGETGSGKTTQLAQYLLED--- 481

  Fly   428 SGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLR 492
             |.|....|..|||||::|:|||.|||.|....||..|||::|||...... ..|.:.|.|:|||
 Worm   482 -GFGDSGLIGCTQPRRVAAMSVARRVADEMGVDLGQDVGYAIRFEDCTSEK-TIIKYMTDGILLR 544

  Fly   493 KL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYF-GIC 554
            :.  :..|...|.||:||.|||.:|:|.|..:||:::....||.:|:.|||:|..||:.:| |.|
 Worm   545 ECLGDGSLDQYSAIIMDEAHERSLNTDVLFGLLREVIAKRADLKLIVTSATMDADKFADFFGGNC 609

  Fly   555 PVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKY 619
            |...:|||.|||:.|                  ..|..|||.
 Worm   610 PTFTIPGRTFPVELF------------------HARTPVEDY----------------------- 633

  Fly   620 SQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQ 684
                           |...:.:|:.:|:  ..:.|.||:|:||...|....:.::..  .|:..:
 Worm   634 ---------------VDAAVKQAVTIHL--GGMDGDILIFMPGQEDIECTCEMIKEK--LGELDE 679

  Fly   685 ---YQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSH 746
               ..:||.:||:|.|.|.|:|:..|.|:.|.|::|||||||:|:|.|:||||....:||::...
 Worm   680 APPLAVLPIYSQLPSDLQAKIFQRAPGGMRKAIVATNIAETSLTVDGILFVIDPGFCKMKVYNPR 744

  Fly   747 NNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTIK 810
            ..:.:.:....|:.:..||.|||||..||.|:.|.:..:|: .|..:..||:.||.|..:.|.:|
 Worm   745 IGMDALSIFPVSQASANQRTGRAGRTGPGQCYRLYTERQFKDELLKSTVPEIQRTNLANVVLLLK 809

  Fly   811 LLRLGSI--HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMV 873
            .|.:..:  .||    ::.||.|.::.:...|..:..||...:|||:||.:...|::|.|.||::
 Worm   810 SLGVDDLLKFHF----MDAPPQDNMLNSMYQLWTLGALDNTGQLTPMGRKMVEFPLDPTLSKMLI 870

  Fly   874 LGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQR 938
            :.|..||:|.:..:.|..|. ..:|....|:...|:.:|.......|||:..:.....||..|
 Worm   871 MSAEMGCSDEVLTIVSMLSV-PAIFFRPKGREEEADAKKEKFQVPESDHLTFLNVYIQWRTHK-- 932

  Fly   939 GEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP-----------EECMIS---HEVDER 989
               ..|::|....|.:..:..:.:.:.||.:::|....|           .:|:.|   |.. .|
 Worm   933 ---YSAKWCADNYLHVKALKKVREVRAQLKEIMQDLKLPLISNGSEWDIVRKCICSAYFHNA-AR 993

  Fly   990 IDGDDPVLDVSLALLC----------LGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVT 1044
            :.|....::|...:.|          :|..|:..|:.|    |...:|..:...|:|:...||..
 Worm   994 LKGIGEYVNVRTGIPCFLHPTSALFGMGFMPDYVVYHE----LIMTAKEYMQCVTAVDAIWLAEL 1054

  Fly  1045 FPYPFFVFGEKIRTRAVSCKQLSMVS 1070
            .|. |:...|..::|    |:|.|.|
 Worm  1055 GPM-FYSIKESKQSR----KELKMES 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	14/79 (18%)
		DEXHc_DHX9	326..559	CDD:350730	93/243 (38%)
		HrpA	378..>889	CDD:441249	177/519 (34%)
		OB_NTP_bind	1002..1079	CDD:400182	19/79 (24%)
mog-1	NP_499212.1	PTZ00121	<24..434	CDD:173412	59/338 (17%)
		HrpA	441..>1056	CDD:441249	211/694 (30%)