DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and rha-2

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_498895.1	Gene:	rha-2 / 176207	WormBaseID:	WBGene00015525	Length:	1148	Species:	Caenorhabditis elegans

Alignment Length:	1208	Identity:	281/1208 - (23%)
Similarity:	460/1208 - (38%)	Gaps:	320/1208 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GQQKRVFDGQSGPQDL-------GEAYRPLNHDG---GDGGNRYSVIDRIQEQRDMNEAEAFDVN 158
            |::|...|..|...|.       ||..:.|...|   ..||.:.....:.:|...:.: :|....
Worm     2 GKRKTKEDNASEDYDANELMIVPGEKRKKLEKSGEKSATGGKKNRNFAKEKEVAKLTK-QAKRKL 65

  Fly   159 AAIHGNWTIENAKERL---------------NIYKQTNNIRDDYKYTPVGPEHARSFLAELSI-- 206
            ||:.....::..:|.|               .:...|...::..| .||.||..:.|..:...
Worm    66 AAVQSRKALKQTQEELFAGLAEFQLDPSKLCQLSSSTKLSKEPEK-APVFPEKLKVFSGKTKTEA 129

  Fly   207 ------YVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPV 265
                  |.|      |..||.|.::...:...          |.||....|::           |
Worm   130 KRTQQDYYP------TDDESSSEEEEEEEEGD----------NDIEDAGNTVE-----------V 167

  Fly   266 KLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAP 330
            |:.|..::.:||.|.|      ||.              .||.:|...::|.|:.....::  |.
Worm   168 KIEPIDLDDVDEAIDG------NPE--------------TNLDQIVVKREDDEESDNEDIL--AL 210

  Fly   331 PQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILT 395
            |                 .||.|:...:..|||           ::..:.|.:|||.|....|:.
Worm   211 P-----------------TTTVINRKKVIVERS-----------KEIQKSRAELPIFAEEMRIVE 247

  Fly   396 AINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN----IYVTQPRRISAISVAERVARE 456
            |||:|.|.::.|.||.||||||.|::.       :.|||:    |.:|:|||::||::|:||..|
Worm   248 AINENLVTVVCGETGSGKTTQIPQFLY-------EAGYASEGELIGITEPRRVAAIAMAQRVGVE 305

  Fly   457 RCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFL 519
            ..:.  |.|.|.:|:|........ |||.|.|||::::|..  |:..|.|::||.|||.:.||.|
Worm   306 LAKP--DEVSYQIRYEGTRSETTN-ILFMTDGVLMKEMEQDVMLKKYSVILIDEAHERSMYSDVL 367

  Fly   520 LVILRDMV----DTYPDLHVILMSATIDTTKFS--KYFGIC--PVLEVPGRAFPVQQFFLEDIIQ 576
            :.:|..:|    .|...|.:::||||:....|:  |.|.:.  .|::|..|.|||...|  :...
Worm   368 IGMLSRIVPLRSKTARPLRLVIMSATLRLDDFTHKKLFPLLTPKVIKVDARQFPVSVHF--EKRT 430

  Fly   577 MTDFVPSAESRRKRKEVEDE----------------EQLLSEDKDEAEINYNKVCEDK------- 618
            ..|::.||  .||...:.:.                :||:::.|....:.|.   .||
Worm   431 PDDYIASA--FRKTCRIHETLPPGAILVFVTGQHEVKQLITKLKKRYPVVYE---TDKNGEVLVK 490

  Fly   619 ----YSQKTRNAMAMLSESDV--------SFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMK 671
                :.:|...|...:...|.        .||.::..||.....|..||...|          ..
Worm   491 GTKEWKEKKVEAAKSIKLEDFKEETPETEDFEDVDDGLMDGDDMNERGAAEAF----------DD 545

  Fly   672 FLQNTNIFGDTSQYQI----------------LPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIA 720
            :.:..|..||.|..::                ||.:|.:...:||:||:..|.|:...::|||:|
Worm   546 YEEFENGDGDLSDGKVENSIGAPPADCEPLYCLPLYSLLSMGKQRRVFDETPAGMRLCVISTNVA 610

  Fly   721 ETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRAR 785
            |||:||..:.:|||....:.:|:.|...::.:|....|:.:.:||.|||||:..|..:.|.|.|.
Worm   611 ETSLTIPGVKYVIDGGFEKRRLYDSITGVSRFAVCRISQASGDQRAGRAGRISAGHAYRLYSSAV 675

  Fly   786 FQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIE-AEVLLREMRCLDAN 849
            :|.......||:...|..::.|.:|.:.:..:.:|   .....|.:.::| ||..|..:..|..:
Worm   676 YQDFVKFADPEILSKPADQLVLHLKSMNIVKVVNF---PFPSAPDEQMLESAEKRLCRLGALSES 737

  Fly   850 DE-------LTPLGRLLARLPIEPRLGKMMVLG---AVFGCADLMAIMASYSSTFSEVFSL--DI 902
            .:       :|.||:.||..|:.|...|.:.:.   .:...|.|:..:.|.......|.||  |.
Worm   738 TKNGKTEARITKLGKTLAVFPLAPSYAKFIAMADQHNLMSHAILLISLLSVREPLIPVSSLRGDT 802

  Fly   903 GQ-------------RRLANHQKA--LSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGL 952
            .:             ||..:|..|  |...|...|.|. ||.|:         ...||.|:..||
Worm   803 PEETKELMKNVLKERRRWCSHTGARRLGDLKVLMHAAS-VAEQI---------KYNARECEKVGL 857

  Fly   953 QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKE 1017
            ::..:......:|||.:::..:     |...|..  .:|.|.|.
Worm   858 RVKALVEARKLRQQLTNIVNAS-----CKKEHAA--ALDSDLPP--------------------- 894

  Fly  1018 KRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIR---TRAVSCKQLSMVSPLQVILFGS 1079
                 .|:.:|.||.:..|..             |.:::.   .|:|..:::...:....::.|.
Worm   895 -----PTDQQAQLLRQMVVAS-------------FSDRLARRVDRSVGQEEVQKGAYETTLIKGH 941

  Fly  1080 RKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDIL-RLEEPYAQ----- 1138
            ..||..:         :.|..|||.......::...:.|:|..|....:.| ||.|.|..
Worm   942 VFIDPCS---------VVFTEEPEFVIYQELVQVNEKKLMTSVCAVDKEWLSRLAESYCNYGEQD 997

  Fly  1139 -----LVKVVKDLCVKSAG-DFG-----LQRESGILPH 1165
                 :...|||:.||:.. .||     |..|:..:||
Worm   998 KNQEPIYDPVKDMVVKTVKVTFGPLNWELPNENRSVPH 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	15/92 (16%)
		DEXDc	393..569	CDD:214692	71/189 (38%)
		DEXDc	402..542	CDD:238005	56/149 (38%)
		ATP-synt_B	<584..644	CDD:304375	14/94 (15%)
		Helicase_C	643..772	CDD:278689	41/144 (28%)
		HA2	842..926	CDD:214852	24/110 (22%)
		OB_NTP_bind	974..1078	CDD:285018	13/106 (12%)
rha-2	NP_498895.1	HrpA	218..989	CDD:224557	215/876 (25%)
		DEXDc	254..394	CDD:238005	56/149 (38%)
		P-loop_NTPase	<350..>477	CDD:304359	36/130 (28%)
		HELICc	577..662	CDD:197757	31/84 (37%)
		HA2	730..822	CDD:214852	18/91 (20%)
		OB_NTP_bind	870..990	CDD:285018	30/174 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810