Protein Alignment mle and ddx-35

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_497420.1
• Gene: ddx-35 / 175308
• WormBaseID: WBGene00022056
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 763
• Identity: 216/763 - (28%)
• Similarity: 335/763 - (43%)
• Gaps: 156/763 - (20%)

  Fly   381 REKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYA----NIYVTQP 441
            |.:|||...|..||........:||.|.|||||:||:.|::|       :.|:|    .|.:|||
 Worm    74 RIRLPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLL-------EAGWAADGRQIVITQP 131

  Fly   442 RRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVSHI 504
            ||::.:::|.|||.|:...||..|||:|||:.|..:. ..:.|.|.|:|||::.|.  |...|.|
 Worm   132 RRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVSDKD-TKVKFMTDGLLLREILADPLLSKYSII 195

  Fly   505 IVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGI----------CPVLEV 559
            ::||.|||..|:|.||.:||.::....||.:|:.|||:|...|..:|.:          ..::.|
 Worm   196 MIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAELFKDFFEMNETGNSDKDTAGIISV 260

  Fly   560 PGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTR 624
            .||..||                                         .:::.|.....|.|...
 Worm   261 EGRTHPV-----------------------------------------AVHHTKTSVPDYCQSAV 284

  Fly   625 NAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQN-TNIFGDTSQYQIL 688
            :.                 :::|.....||.|||||.|.:.:..:.:.|:. .....:..:..::
 Worm   285 DT-----------------VINIHKHENPGDILVFLTGQDEVEDVCEKLRELAGNLKNCDRLWVV 332

  Fly   689 PCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYA 753
            ||:..:|..||.|.|:..|.|..|::::|||||.||||..|.:|||....:::...:.|.:.:..
 Worm   333 PCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLM 397

  Fly   754 TVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIH 818
            .|..||.:.|||.|||||:|||.|:.|...:.|:...:...||:.|..:....|.:|.|.:.::|
 Worm   398 RVTVSKASAEQRAGRAGRIRPGKCYRLYPESEFERFAEGTVPEIQRCQMASTILQLKALGVQNVH 462

  Fly   819 --HFLSKALEPPPVDAVIEAEVLLREMRCLDANDELT-PLGRLLARLPIEPRLGKMMVLGAVFGC 880
              |:||    |||..|:|....||..:..:|...:|| |||..:|..|:.|...|.::..|.|||
 Worm   463 RFHYLS----PPPSWAMINGLELLYALGAIDETSQLTSPLGLQMAEFPLPPMHSKCLLKSAEFGC 523

  Fly   881 A-DLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMW----RREKQRGE 940
            : :::.|:|...  ..:||.....||..|:..:.....:..||:.|:.....:    |.:|...:
 Worm   524 STEMVTIVAMMQ--IQDVFITPYRQRHQADVIRKKFAVEEGDHMTMLNVFTKFVENGRSKKWCSD 586

  Fly   941 HMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLC 1005
            |    |.:::|| |...||    :.||:.||::  |..|     :|..|
 Worm   587 H----FVNYRGL-MRADNV----RSQLVRLLKR--FEIE-----KVSSR---------------- 619

  Fly  1006 LGLYPNICVHKEKRKVLTTE--SKAALLHKTSVNCSNLAVTFPYPFFVF-GEKIRTRAVSCKQLS 1067
             ||   |...:..|:.|.|.  |:||..|.|.   ..:.|...:||.:: |..|..:....|.:.
 Worm   620 -GL---INCSENIRQCLVTGFFSQAAQYHYTG---KYMTVKESFPFNMYKGSSIMFKKDYPKWVI 677

  Fly  1068 MVSPLQVILFGSRKIDLAANNIVRVDNWL--------NFDIEPELAAK 1107
            ....:|         |...:..|....||        .|..|.|||.|
 Worm   678 FTEVMQ---------DSIRDVTVIEPEWLYELAPHYYEFGTEGELAEK 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	71/193 (37%)
		HrpA	378..>889	CDD:441249	162/528 (31%)
		OB_NTP_bind	1002..1079	CDD:400182	18/79 (23%)
ddx-35	NP_497420.1	HrpA	95..>703	CDD:441249	203/727 (28%)