Protein Alignment mle and mog-4

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_497027.1
• Gene: mog-4 / 175117
• WormBaseID: WBGene00003392
• Length: 1008
• Species: Caenorhabditis elegans
• Alignment Length: 1143
• Identity: 280/1143 - (24%)
• Similarity: 471/1143 - (41%)
• Gaps: 263/1143 - (23%)

  Fly     3 IKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEP-NTYIGV-----GNSTNKKDAEKNAC 61
            |:||..|..::...:.. ..||.||...:  |.|..:.. |..:||     .:||..|:..|.
 Worm    55 IQSFADQLMSRMPRQAT-SARQRGPTTAE--LAEQELNRLNRAVGVLEDYSASSTKTKNVRKR-- 114

  Fly    62 RDFVNYLVRVGKLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPL 126
                    :......::.|..|                              |.|   |::.:|.
 Worm   115 --------KESSSEDDEAPIKA------------------------------SKP---GKSVKPS 138

  Fly   127 NHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNI----RDDY 187
            ..|..:     |.|:.::.:.|.:.||...:.|.|       |.||:    .:|.|:    |||.
 Worm   139 KSDDSE-----SDIEAMEAKLDADIAERDALAARI-------NKKEK----DKTRNVMEKKRDDN 187

  Fly   188 K------YTPVGPEHARSF--------LAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQ 238
            |      ...:..|..|.:        |.||...|.. ::|:.|||..:.::.|.    :...::
 Worm   188 KDKEGSSMDKLREESRRQYLKKRKVDKLEELEAIVHD-DQTLFAREKLTKREKAD----MEYRKK 247

  Fly   239 LFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPP--- 300
            :.........:|.:.|.|...|.....|..|:...:.||            .:.:...||..
 Worm   248 VLEYTKAHGKAGDVMKMKRYHLPDASTKQIPSQYVEDDE------------EDFRPGGDGAKWEE 300

  Fly   301 ---IPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYER 362
               :..:::|...|:.:    |.||..::                :||           .:|:.:
 Worm   301 EQLMASMLHLGAKDAKR----KEQEFELL----------------LDE-----------KVDFIQ 334

  Fly   363 SLRDRRQN--------DNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQ 419
            :|:....|        :.:.....|.|:.||:.|.|...:.|:.::.|:||.|.||.|||||:.|
 Worm   335 ALQMPGTNEEVVETEAEKKKMSIEETRKSLPVYAFRDAFIEAVKEHQVLIIEGETGSGKTTQLPQ 399

  Fly   420 YILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILF 484
            |:.:...|  :|| ..|..|||||::|:|||.|||.|...:||..||||:|||...... ..:.:
 Worm   400 YLYEAGFC--EGG-KRIGCTQPRRVAAMSVAARVADEVGCKLGTQVGYSIRFEDCTSEK-TVLKY 460

  Fly   485 CTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKF 547
            .|.|:|||:.  |..|...|.:::||.|||.:::|.|..:::|:.....||.:::.|||:|..||
 Worm   461 MTDGMLLREFLNEPDLASYSVMMIDEAHERTLHTDILFGLVKDIARFRKDLKLLISSATLDAEKF 525

  Fly   548 SKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYN 612
            |.:|...|:..:|||.|||                                         :|.|.
 Worm   526 SSFFDDAPIFRIPGRRFPV-----------------------------------------DIYYT 549

  Fly   613 KVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMK-FLQNT 676
            :..|..|               |...::..:.:|: ::.:||.|||||.|...|..:.: .::.:
 Worm   550 QAPEADY---------------VDAAIVTIMQIHL-TQPLPGDILVFLTGQEEIETVQEALMERS 598

  Fly   677 NIFGDTSQYQI-LPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARM 740
            ...|...:..| ||.::.:|.|.|.|:|||.|:...|::|:|||||||:|||.|.:|||...::.
 Worm   599 KALGSKIKELIPLPVYANLPSDLQAKIFEPTPKDARKVVLATNIAETSVTIDGINYVIDPGFSKQ 663

  Fly   741 KLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHE 804
            ..|.:.:.:.....|..||....||.|||||..||.||.|.:...:: .||:...||:.||.|..
 Worm   664 NSFDARSGVEHLHVVTISKAAANQRAGRAGRTGPGKCFRLYTAWAYKHELEEQPIPEIQRTNLGN 728

  Fly   805 MALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLG 869
            :.|.:|.|.:..:.||  ..|:|||.:.::.|...|..:..|:...|||.|||.:|..|.:|.:.
 Worm   729 VVLMLKSLGIHDLVHF--DFLDPPPQETLVIALEQLYALGALNHRGELTKLGRRMAEFPCDPCMS 791

  Fly   870 KMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRR 934
            ||::....:.|::.:..:|:..|..:.||.....|...|:..:....:...||:.::.....|:.
 Worm   792 KMIIASEKYECSEEIVTIAAMLSCNAAVFYRPKAQVIHADSARKGFWSPAGDHITLMNVYNKWQE 856

  Fly   935 EKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDV 999
            ..     ...|:|....:|..||....|.:.||:.||::.          |::.:...|  .:.:
 Worm   857 SS-----FSQRWCVENYVQHRTMKRARDVRDQLVGLLERV----------EIETKSSTD--TIKI 904

  Fly  1000 SLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYP----------FFVFGE 1054
            ..|:.. |.:.|:      .|:..|.....:.||.:        |.|:|          :.|:.|
 Worm   905 RKAITA-GYFYNV------SKLDNTGHYKTVKHKHT--------THPHPNSCLFEETPRWVVYFE 954

  Fly  1055 KIRTRAVSCKQLSMVSP---LQVI--LFGSRKIDLAAN 1087
            .:.|.....:::|.:..   |:|.  .:..|:::.|.|
 Worm   955 LVFTSKEFMREMSEIESGWLLEVAPHYYKGRELEDATN 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	17/72 (24%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	20/91 (22%)
		DEXHc_DHX9	326..559	CDD:350730	78/242 (32%)
		HrpA	378..>889	CDD:441249	169/515 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	16/91 (18%)
mog-4	NP_497027.1	PTZ00121	<107..363	CDD:173412	58/362 (16%)
		HrpA	355..>980	CDD:441249	206/719 (29%)