Protein Alignment mle and mog-5

DIOPT Version :9

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_495019.1
• Gene: mog-5 / 173920
• WormBaseID: WBGene00003393
• Length: 1200
• Species: Caenorhabditis elegans
• Alignment Length: 1096
• Identity: 279/1096 - (25%)
• Similarity: 453/1096 - (41%)
• Gaps: 266/1096 - (24%)

  Fly    37 VRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVGKLNTNDVPADAGASGGGPRTGLEGAGM-- 99
            |:|:.|.......|.:.|:.::|:..|          ||..:...:..|.|..|||.......
 Worm   287 VKVKVNKIENGKISLSMKEVDQNSGED----------LNPRETDLNPDAIGVRPRTPPASTSSWM 341

  Fly   100 ---AGGSGQQKRVFDGQSGPQ-DLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEA------ 154
               |.|.||         ||. .:|         ||....|.|..:| .|.|.|..|..
 Worm   342 NPEASGVGQ---------GPSTSIG---------GGKARVRISTPER-WELRQMQGAGVLTATDM 387

  Fly   155 --FDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSF---LAELSIYVPALNRT 214
              ||....:..|:..|:..|.:.|    ..:.|:       |:..|.:   .||:.   |.   .
 Worm   388 PDFDEEMGVLRNYDDESDGEDIEI----ELVEDE-------PDFLRGYGKGGAEIE---PV---K 435

  Fly   215 VTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVI 279
            |.....||..::|....|||                  |::|:.:::.              :..
 Worm   436 VVKNPDGSLAQAALMQGALS------------------KERKETKIQA--------------QRE 468

  Fly   280 KGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIP-WAPPQANWNTWHACNI 343
            :.:|.......|.:| ||    |:..|.|...|:.:..::..:...:| |..           ::
 Worm   469 RDMDTQKGFSSNARI-LD----PMSGNQSTAWSADESKDRNNKMKEMPEWLK-----------HV 517

  Fly   344 DEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGN 408
            ..|..||..              ||.|    ...:|.||.|||.|::..::.|:.||.::::.|.
 Worm   518 TAGGKATYG--------------RRTN----LSMVEQRESLPIFALKKNLMEAMIDNQILVVVGE 564

  Fly   409 TGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFES 473
            ||.|||||:.||.::    :|.|....|..|||||::|:|||:|||.|...:||..|||::|||.
 Worm   565 TGSGKTTQMTQYAIE----AGLGRRGKIGCTQPRRVAAMSVAKRVAEEYGCKLGTDVGYTIRFED 625

  Fly   474 VFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVI 536
            ...:. ..|.:.|.|:|||:  ::..|.|.|.|::||.|||.:::|.|..:|:......|:|.:|
 Worm   626 CTSQD-TIIKYMTDGMLLRECLIDPDLSGYSLIMLDEAHERTIHTDVLFGLLKAAARKRPELKLI 689

  Fly   537 LMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLS 601
            :.|||:|:.|||:||...|:..:|||.|||
 Worm   690 ITSATLDSVKFSEYFLEAPIFTIPGRTFPV----------------------------------- 719

  Fly   602 EDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPG---- 662
                  ||.|.:..|..|                 .|.....:|.|.....||.:||||.|
 Worm   720 ------EILYTREPESDY-----------------LEAAHITVMQIHLTEPPGDVLVFLTGQEEI 761

  Fly   663 ---WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSI 724
               ..:::..||     ::..|..:..|||.:..:|.:.|.::|:|.|.|..|::::|||||||:
 Worm   762 DTSCEVLYERMK-----SMGPDVPELIILPVYGALPSEMQTRIFDPAPAGKRKVVIATNIAETSL 821

  Fly   725 TIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQAL 789
            |||.|.:|:|....:.|::...:.:.|......|:...:||.|||||..||.|:.|.:.   :|.
 Worm   822 TIDGIFYVVDPGFVKQKIYNPKSGMDSLVVTPISQAAAKQRSGRAGRTGPGKCYRLYTE---RAF 883

  Fly   790 EDNL----TPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDAND 850
            .|.:    .||:.||.|....|.:|.:.:.::..|  ..::.||:|::|.|...|..:..||.:.
 Worm   884 RDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDF--DFMDAPPLDSMITALNTLHTLSALDGDG 946

  Fly   851 ELTPLGRLLARLPIEPRLGKMMVLGAVFGCA-DLMAIMASYSSTFSEVFSLDIGQRRLANHQKAL 914
            .||.|||.:|..|:||.|.|::::....||: :::.|:|..:  ...:|.....::..|:.:||.
 Worm   947 LLTKLGRRMAEFPLEPSLSKLLIMSVDLGCSEEVLTIVAMLN--VQNIFYRPKEKQDHADQKKAK 1009

  Fly   915 SGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQ------ 973
            ......||:.::.....|     :..|....:|....:|:.:|....|.::|||.::.:
 Worm  1010 FHQPEGDHLTLLAVYNSW-----KNHHFSQPWCFENFIQVRSMKRAQDIRKQLLGIMDRHKLLMV 1069

  Fly   974 --------------AGF--------PEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHK 1016
                          :||        |:|     ......||.:..:..|.|  |....|...|:.
 Worm  1070 SCGRDVSRVQKAICSGFFRNAAKRDPQE-----GYRTLTDGQNVYIHPSSA--CFQQQPEWVVYH 1127

  Fly  1017 EKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPL 1072
            |  .|:||  |..:...|:::...| |.|...||..|:.  |:..:.|:...:.||
 Worm  1128 E--LVMTT--KEYMREVTAIDPKWL-VEFAPSFFKIGDS--TKLSTFKRNQKIDPL 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	7/30 (23%)
		DSRM	170..240	CDD:214634	15/72 (21%)
		DEXDc	393..569	CDD:214692	74/177 (42%)
		DEXDc	402..542	CDD:238005	57/141 (40%)
		ATP-synt_B	<584..644	CDD:304375	6/59 (10%)
		Helicase_C	643..772	CDD:278689	44/135 (33%)
		HA2	842..926	CDD:214852	23/84 (27%)
		OB_NTP_bind	974..1078	CDD:285018	27/107 (25%)
mog-5	NP_495019.1	S1_DHX8_helicase	234..311	CDD:240189	6/23 (26%)
		DEXDc	534..721	CDD:214692	81/232 (35%)
		DEXDc	557..695	CDD:238005	57/142 (40%)
		HELICc	766..870	CDD:197757	36/108 (33%)
		HA2	939..1021	CDD:214852	23/83 (28%)
		OB_NTP_bind	1055..1154	CDD:285018	23/110 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810