Protein Alignment mle and let-355

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_491604.3
• Gene: let-355 / 172199
• WormBaseID: WBGene00020263
• Length: 856
• Species: Caenorhabditis elegans
• Alignment Length: 926
• Identity: 229/926 - (24%)
• Similarity: 390/926 - (42%)
• Gaps: 235/926 - (25%)

  Fly   220 SGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKK--------KDEQLKPYPVKLSPNLINKID 276
            :|:::::..:.      ::..:|..::..:..||||        |:|:|.....:::..::.| :
 Worm    44 NGNSRQTGGQE------QKFQNLEALKKKTMLLKKKKKQMNNFQKEEELLSSTFRITNGILKK-E 101

  Fly   277 EVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHAC 341
            :.|:...:....|:.:      |..|:....:..:::.....|...|.   .:||....|
 Worm   102 KKIEVTTISTQTPKKL------PKTPISTPSNSKNATPMSTRKHSSSQ---QSPPHFEAN----- 152

  Fly   342 NIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIR 406
                                            |.:|  .|.:|||.|:..:::..:.....:|:.
 Worm   153 --------------------------------YEKF--SRPQLPIDAVEQQLMYELASQETLIVI 183

  Fly   407 GNTGCGKTTQIAQYILDDYICSGQGGYAN---IYVTQPRRISAISVAERVARERCEQLGDTVGYS 468
            |.||.||:||:.|      :|. :.|.||   |.||||||::|||:|.|||.|....:|..|||.
 Worm   184 GETGSGKSTQVPQ------LCV-RAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGYH 241

  Fly   469 VRFESVFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVD--- 528
            ||||:..... ..|.:.|.|::|||  :...|...|.:|:||.|||.::||.|:.|||...|
 Worm   242 VRFENATCHK-TKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDVLMCILRQCQDQRR 305

  Fly   529 -TYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDII----QMTDFVPSAESRR 588
             |...|.:|:||||:...||..||....|:.|.||.||::.|.:...|    ..||:|
 Worm   306 ETNNPLRLIIMSATLQAEKFQSYFNNAKVVLVAGRTFPIEVFHVNPKINKSFSSTDYV------- 363

  Fly   589 KRKEVEDEEQLLSEDKDEAEINYNKVCEDKY----SQKTRNAMAMLSESDVSFELLEALLMHIKS 649
                                  ||.|...||    ..|.|:.:..|:.|    |.:||:...:..
 Worm   364 ----------------------YNAVICVKYVHLTEPKGRDILVFLTGS----EEIEAVASQLAE 402

  Fly   650 KN--IPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTK 712
            .|  :|.:..|.:|                          :|.::.:..::|::.|...|:|..|
 Worm   403 LNGSLPASADVLMP--------------------------VPLYAALRPEKQKEAFRKTPQGARK 441

  Fly   713 IILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFC 777
            :|:||||||||:||..|..|||..|.:.|.|.:.|.:........||...:||.|||||..||.|
 Worm   442 VIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDVLKVHNVSKAQAKQRAGRAGRDAPGKC 506

  Fly   778 FTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLRE 842
            :.|.||..|...|....||:.|..|  .|..::|::||..:....|.::||..|.:..|   |.|
 Worm   507 YRLYSREDFHKFEAENMPEILRCNL--SATFLELMKLGMKNPHRLKLIDPPETDNINAA---LLE 566

  Fly   843 MRCLDA----NDE-----LTPLGRLLARLPIEPRLGKMMVLGAVFGC-ADLMAIMASYSSTFSEV 897
            :..|.|    |.:     ||.:|......|:.|...:::......|| .:.:.|:|:..:  ..:
 Worm   567 LTSLGAIRPVNSDRSKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQT--DAL 629

  Fly   898 FS----------LDIGQRRLANHQKALSGTKCSDHVAM----IVASQMWRREKQRGEHMEAR--- 945
            ||          :|..:||..        |:..||:.:    :|.:|.:.:..::.| .:||
 Worm   630 FSGAGDSKSDADVDRIRRRFE--------TREGDHITLLKLVLVTNQFFDQLNKKTE-SDARYGK 685

  Fly   946 ---------------FCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERID---- 991
                           ||:        .|:|.:..      |:.|...||.:....:::::.
 Worm   686 ANKSLEREYNQTIRKFCN--------DNMINEQH------LKTASMIEEQLKQIAIEQKVTFSTC 736

  Fly   992 GDDPVLDVSLALLCLGLYPNICVH---KEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFG 1053
            |.| .:.:..| |.||::.|.|.:   :::.:::...:....:|.:|  |  |:.:.| .:.||.
 Worm   737 GAD-FMKMRKA-LALGMFLNSCEYDRQEDRYRLMINPAITLKIHPSS--C--LSRSKP-AYIVFS 794

  Fly  1054 EKIRTRAVSCKQLSMV 1069
            |.::|..:...|::::
 Worm   795 ELMKTNDLFALQVTLI 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	1/20 (5%)
		DEXHc_DHX9	326..559	CDD:350730	79/241 (33%)
		HrpA	378..>889	CDD:441249	168/539 (31%)
		OB_NTP_bind	1002..1079	CDD:400182	16/71 (23%)
let-355	NP_491604.3	HrpA	159..>636	CDD:441249	170/550 (31%)
		OB_NTP_bind	743..815	CDD:400182	16/74 (22%)