Protein Alignment mle and DHX15

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001349.2
• Gene: DHX15 / 1665
• HGNCID: 2738
• Length: 795
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 199/678 - (29%)
• Similarity: 330/678 - (48%)
• Gaps: 93/678 - (13%)

  Fly   374 YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYV 438
            |...|:.|.:||:...:......:..:...::.|.||.||||||.|:.: :|:.|..|....:..
Human   127 YYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCV-EYMRSLPGPKRGVAC 190

  Fly   439 TQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAIL-FCTVGVLLRKL--EAGLRG 500
            |||||::|:|||:|||.|....||..||||:|||......  .|| :.|.|:|||:.  :..|..
Human   191 TQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAK--TILKYMTDGMLLREAMNDPLLER 253

  Fly   501 VSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFP 565
            ...||:||.|||.:.:|.|:.:|:::|....||.||:||||:|..||..||..||:|.:|||..|
Human   254 YGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHP 318

  Fly   566 VQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAML 630
            |:.|          :.|..|                .|..||.|            :|...:.|.
Human   319 VEIF----------YTPEPE----------------RDYLEAAI------------RTVIQIHMC 345

  Fly   631 SESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQN--TNIFGDTSQYQILPCHSQ 693
            .|.:                   |.:|:||.|...|....|.::.  .::..:....:|:|.:|.
Human   346 EEEE-------------------GDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYST 391

  Fly   694 IPRDEQRKVFEPVP----EGV--TKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSY 752
            :|..:|:::|||.|    .|.  .|:::||||||||:|||.:|||||...|:.|::.....:.|.
Human   392 LPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESL 456

  Fly   753 ATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQA-LEDNLTPEMFRTPLHEMALTIKLLRLGS 816
            .....||.:.:||.|||||.|||.||.|.:...::. ::||..||:.|:.|..:.|.:|.|.:..
Human   457 LVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDD 521

  Fly   817 IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCA 881
            :.||  ..::||..:.::.|..||..:..|:.:.:||.||.::|..|::|:|.||::....:.|:
Human   522 LVHF--DFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCS 584

  Fly   882 -DLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEAR 945
             ::::|.|..|  ..:.|......::.|:..|........||:.::.....:::..:..:.....
Human   585 NEVLSITAMLS--VPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDN 647

  Fly   946 FCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYP 1010
            |.:::.| ||..||    :|||..::.:...|..   |.:...|    |..:::..||: .|.:.
Human   648 FINYRSL-MSADNV----RQQLSRIMDRFNLPRR---STDFTSR----DYYINIRKALV-TGYFM 699

  Fly  1011 NICVHKEK--RKVLTTESKAALLHKTSV 1036
            .: .|.|:  ..:...:::...||.::|
Human   700 QV-AHLERTGHYLTVKDNQVVQLHPSTV 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	75/187 (40%)
		HrpA	378..>889	CDD:441249	170/523 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	8/37 (22%)
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108
		HrpA	136..>763	CDD:441249	196/669 (29%)
		DEAH box	260..263		2/2 (100%)