DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mle and DHX9

DIOPT Version :10

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens


Alignment Length:1330 Identity:665/1330 - (50%)
Similarity:895/1330 - (67%) Gaps:105/1330 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVN 66
            |:|:|||.:|.|.::.|.::||..|.||||:|:|||:||...|.|:|||||||||:.||.|||||
Human     3 DVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVN 67

  Fly    67 YLVRVGKLNTNDVPA---------------DAGASG------GGP-----RTGLEGAGMAGGSGQ 105
            ||||:.::.:.:|||               .|.|.|      |||     ....|.....|.||.
Human    68 YLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGY 132

  Fly   106 QKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENA 170
                  |..||          ..|.|.....|......||.:...|:|..|:||.:|||||:|||
Human   133 ------GVPGP----------TWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENA 181

  Fly   171 KERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSL 235
            |.|||.|.|...|:.:||||.|||:|.|||:||::||:..|.|.:.|||.|||||.|::||||||
Human   182 KARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSL 246

  Fly   236 VRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPP 300
            ||||:||.|:|.:||..|||:.|.::||.|.||.:|.:::..:|:.|:|.::.|.      :.|.
Human   247 VRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPPP------EDPS 305

  Fly   301 IPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLR 365
            :|:.:|:.:: :..:..:::.:..|:||:|||:|||.|.:.|||||.||..:.:.:|||.:..|.
Human   306 VPVALNIGKL-AQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELM 369

  Fly   366 DRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQ 430
            .:.:.|::.:..|:.||.||:....||||.||:.|.||||||.||||||||:.|:||||:|.:.:
Human   370 YQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDR 434

  Fly   431 GGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLE 495
            ....||.|||||||||:|||||||.||.|:.|.:.||||||||:.|||:.:|:||||||||||||
Human   435 AAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLE 499

  Fly   496 AGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVP 560
            ||:||:||:|||||||||:|:|||||:|||:|..||::.::||||||||:.|.:||..||::||.
Human   500 AGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVY 564

  Fly   561 GRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRN 625
            ||.:|||::||||.||||.|||..:.::|:.:.:|.    .||.|   .|.|.:|.|:|..:||.
Human   565 GRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDG----GEDDD---ANCNLICGDEYGPETRL 622

  Fly   626 AMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPC 690
            :|:.|:|.:..|||:||||.:|::.|:|||:||||||||||:.:.|.|:....|| :.:|||||.
Human   623 SMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFG-SHRYQILPL 686

  Fly   691 HSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATV 755
            ||||||:||||||:|||.||||:|||||||||||||:|:|:|||.||.::||||:|||:|:||||
Human   687 HSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATV 751

  Fly   756 WASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHF 820
            |||||||||||||||||||||||.|||||||:.||.::|||||||||||:||:|||||||.|..|
Human   752 WASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQF 816

  Fly   821 LSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMA 885
            |:||:||||:|||||||..|||:..||||||||||||:||:||||||.||||::|.:|...|.:.
Human   817 LAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAIC 881

  Fly   886 IMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWK 950
            .:|: ::.|.|.| ::.| :||....:..:|.:.|||||::...|.|...:..||..|.|||:.|
Human   882 TIAA-ATCFPEPF-INEG-KRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHK 943

  Fly   951 GLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVH 1015
            .|.|:|:.:.|:||.||.::|..:||||:|:::.....  .|.|..|||.::||..|:|||:|.|
Human   944 RLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTN--TGPDNNLDVVISLLAFGVYPNVCYH 1006

  Fly  1016 KEKRKVLTTESKAALLHKTSVNC--SNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFG 1078
            |||||:||||.:.||:||:||||  |:..:.:|.|||||||||||||:|.|.:::|:|||::||.
Human  1007 KEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFA 1071

  Fly  1079 SRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVV 1143
            |:|:. :...||.||:|:...|..|.||.|..|:.|:|.|:......|:.|.:|:....:::.::
Human  1072 SKKVQ-SDGQIVLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMI 1135

  Fly  1144 KDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGRFTNSSFGRRGNGRTFGGGYGNN 1208
            :.:...||.  |:....|     |.::.||..|||..|::     |.|..|||.....||||   
Human  1136 RQISRPSAA--GINLMIG-----STRYGDGPRPPKMARYD-----NGSGYRRGGSSYSGGGY--- 1185

  Fly  1209 GGGYGNNGGGYGNIGGGYGNNAGGYGNNGGYGNN-GGGYR--NNGGGYGNNGGGYGNKRGGFGDS 1270
            ||||  :.||||:  ||||.:|..:  ..|||.. |||||  :.||..||:||.|....||:   
Human  1186 GGGY--SSGGYGS--GGYGGSANSF--RAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGY--- 1241

  Fly  1271 FESNRGSGGGFRNGDQG---------GRWG 1291
                |||||..|.|.:|         ||.|
Human  1242 ----RGSGGFQRGGGRGAYGTGYFGQGRGG 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM_DHX9_rpt1 2..70 CDD:380683 41/67 (61%)
DSRM_DHX9_rpt2 167..241 CDD:380684 46/73 (63%)
DEXHc_DHX9 326..559 CDD:350730 139/232 (60%)
HrpA 378..>889 CDD:441249 331/510 (65%)
OB_NTP_bind 1002..1079 CDD:400182 48/78 (62%)
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250 118/262 (45%)
DSRM_DHX9_rpt1 3..71 CDD:380683 41/67 (61%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9 2/3 (67%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 53..55 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..118 6/34 (18%)
DSRM_DHX9_rpt2 178..252 CDD:380684 46/73 (63%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYX 182..186 2/3 (67%)
Interaction with BRCA1. /evidence=ECO:0000269|PubMed:9662397 230..325 40/101 (40%)
siRNA-binding. /evidence=ECO:0000305|PubMed:23361462 234..236 1/1 (100%)
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269|PubMed:9323138 255..664 215/422 (51%)
Necessary for interaction with H2AX. /evidence=ECO:0000269|PubMed:15613478 313..952 378/650 (58%)
DEXHc_DHX9 330..563 CDD:350730 139/232 (60%)
MTAD. /evidence=ECO:0000269|PubMed:11416126 331..380 21/48 (44%)
HrpA 388..>886 CDD:441249 329/506 (65%)
Core helicase. /evidence=ECO:0000305|PubMed:25062910 398..809 273/418 (65%)
DEIH box 511..514 2/2 (100%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 586..595 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..608 5/26 (19%)
HA2. /evidence=ECO:0000269|PubMed:25062910 831..919 46/90 (51%)
OB-fold. /evidence=ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208 958..1074 62/117 (53%)
OB_NTP_bind 994..1073 CDD:400182 48/78 (62%)
RGG. /evidence=ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:9111062 1150..1270 58/144 (40%)
Nuclear localization signal (NLS2). /evidence=ECO:0000269|PubMed:16375861 1155..1173 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1248 11/25 (44%)

Return to query results.
Submit another query.