DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and DHX8

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_004932.1	Gene:	DHX8 / 1659	HGNCID:	2749	Length:	1220	Species:	Homo sapiens

Alignment Length:	973	Identity:	251/973 - (25%)
Similarity:	423/973 - (43%)	Gaps:	207/973 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 NAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCAL 233
            |...|.|:..:||  .:.....|..|.|. |.::...:...:|.|....|.|...|..
Human   347 NPNRRRNLVGETN--EETSMRNPDRPTHL-SLVSAPEVEDDSLERKRLTRISDPEKWE------- 401

  Fly   234 SLVRQLFHLNVI--EPF------SGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPR 290
              ::|:...||:  |.|      :|.|.|..||:.:...::    |:.:....::|
Human   402 --IKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIE----LVEEEPPFLRG--------- 451

  Fly   291 NIKIELDGPPIPLIVN----LSRIDSSQ----------QDGEKRQESSVIP------WAPPQANW 335
            :.|..:|..||.::.|    ||:....|          :..::..|...||      |..|..:
Human   452 HTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPD- 515

  Fly   336 NTWHACNIDEGELATTSIDDLSMDYERSLRDRRQND-NEYRQ-----------------FLEFRE 382
                    .||.....::..:.|         ..|| .|:::                 .||.||
Human   516 --------AEGRQIAANMRGIGM---------MPNDIPEWKKHAFGGNKASYGKKTQMSILEQRE 563

  Fly   383 KLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN---IYVTQPRRI 444
            .|||..::.:::.|::||.::|:.|.||.||||||.||:       .:.||.:   |..|||||:
Human   564 SLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYL-------AEAGYTSRGKIGCTQPRRV 621

  Fly   445 SAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVD 507
            :|:|||:||:.|....||..|||::|||.. ..|...|.:.|.|:|||:  ::..|...:.|::|
Human   622 AAMSVAKRVSEEFGCCLGQEVGYTIRFEDC-TSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLD 685

  Fly   508 EIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLE 572
            |.|||.:::|.|..:|:..|....|:.:|:.|||:|..|||:||...|:..:|||.:||
Human   686 EAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPV------ 744

  Fly   573 DIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSF 637
                                               ||.|.|..|..|               :..
Human   745 -----------------------------------EILYTKEPETDY---------------LDA 759

  Fly   638 ELLEALLMHIKSKNIPGAILVFLPG-------WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIP 695
            .|:..:.:|:...  ||.|||||.|       ..:::..||     ::..|..:..|||.:|.:|
Human   760 SLITVMQIHLTEP--PGDILVFLTGQEEIDTACEILYERMK-----SLGPDVPELIILPVYSALP 817

  Fly   696 RDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKT 760
            .:.|.::|:|.|.|..|::::|||||||:|||.|.:|:|....:.|::.|...:........|:.
Human   818 SEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQA 882

  Fly   761 NLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLT---PEMFRTPLHEMALTIKLLRLGSIHHFLS 822
            ..:||.|||||..||.|:.|.:...::  ::.||   ||:.||.|....|::|.:.:..:..|
Human   883 QAKQRAGRAGRTGPGKCYRLYTERAYR--DEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSF-- 943

  Fly   823 KALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIM 887
            ..::.||::.:|.|...|..:..||....||.|||.:|..|:||.|.||:::....||::.|..:
Human   944 DFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTI 1008

  Fly   888 ASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGL 952
            .|..|. ..||.....::.||:.:||.......||:.::.....|:..|     ....:|....:
Human  1009 VSMLSV-QNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNK-----FSNPWCYENFI 1067

  Fly   953 QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKE 1017
            |..::....|.::|:|.::.:          |::|....|...| .|..| :|.|.:.| ...|:
Human  1068 QARSLRRAQDIRKQMLGIMDR----------HKLDVVSCGKSTV-RVQKA-ICSGFFRN-AAKKD 1119

  Fly  1018 KRKVLTT--ESKAALLHKTSVNCSNLAVTFPYP-FFVFGEKIRTRAVSCKQLSMVSPLQVILF 1077
            .::...|  :.:...:|.:|      |:....| :.|:.|.:.|.....::::.:.|..::.|
Human  1120 PQEGYRTLIDQQVVYIHPSS------ALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEF 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	14/69 (20%)
		DEXDc	393..569	CDD:214692	73/180 (41%)
		DEXDc	402..542	CDD:238005	57/144 (40%)
		ATP-synt_B	<584..644	CDD:304375	7/59 (12%)
		Helicase_C	643..772	CDD:278689	45/135 (33%)
		HA2	842..926	CDD:214852	27/83 (33%)
		OB_NTP_bind	974..1078	CDD:285018	20/107 (19%)
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..266
		RpsA	<263..422	CDD:223613	19/86 (22%)
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..372		7/26 (27%)
		HrpA	557..1219	CDD:224557	206/720 (29%)
		DEAH box	685..688		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810