DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx9

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_011246220.1	Gene:	Dhx9 / 13211	MGIID:	108177	Length:	1384	Species:	Mus musculus

Alignment Length:	1386	Identity:	681/1386 - (49%)
Similarity:	915/1386 - (66%)	Gaps:	144/1386 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVN 66
            |||:|||.:|.|.::.|.::||..|.||||:|:||||||...|.|:|||||||||:.||.|||||
Mouse     3 DIKNFLYAWCGKRKMTPAYEIRAVGNKNRQKFMCEVRVEGFNYAGMGNSTNKKDAQSNAARDFVN 67

  Fly    67 YLVRVGKLNTNDVPA--------------DAGASG--------GGP-------------RTGLEG 96
            ||||:.::.:.:|||              |:.||.        |||             .:|:|.
Mouse    68 YLVRINEVKSEEVPAVGIVPPPPILSDTSDSTASAAEGLPAPMGGPLPPHLALKAEAENNSGVES 132

  Fly    97 AGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAI 161
            :|.            |..||          ..|.|.....|......||.:...|:|..|:||.:
Mouse   133 SGY------------GSPGP----------TWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGL 175

  Fly   162 HGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKS 226
            |||||:||||.|||.|.|...|:.:||||.|||:|.|||:||::||:..|.|.:.|||.|||||.
Mouse   176 HGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKL 240

  Fly   227 ASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRN 291
            |::||||||||||:||.|||.:||..|||:.|:::||.|.|||:|..::..|::.|||.:|.|
Mouse   241 AAQSCALSLVRQLYHLGVIEAYSGLTKKKEGERVEPYKVFLSPDLELQLQNVVQELDLEIVPP-- 303

  Fly   292 IKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDL 356
               .:| |.:|:|:|:.:: :..:..:::....|:||:|||:|||.|.:.|||||.||..|.:.:
Mouse   304 ---PVD-PSMPVILNIGKL-AHFEPSQRQNAVGVVPWSPPQSNWNPWTSSNIDEGPLAYASTEQI 363

  Fly   357 SMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYI 421
            |||.:..|..:.:.|:..:..|:.||.||:....:|||.||:.|.||||||.||||||||:.|||
Mouse   364 SMDLKNELTYQMEQDHNLQSVLQERELLPVKKFEAEILEAISSNSVVIIRGATGCGKTTQVPQYI 428

  Fly   422 LDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCT 486
            |||:|.:.:....||.|||||||||::||||||.||.|:.|.:.||||||||:.|||:.:|:|||
Mouse   429 LDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFCT 493

  Fly   487 VGVLLRKLEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYF 551
            |||||||||||:||:||:|||||||||:|:|||||:|||:|..||::.::|||||||||.|.:||
Mouse   494 VGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYF 558

  Fly   552 GICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCE 616
            ..||::||.||.||||::||||.||||.|:|..:. :|:|:.||:.   .||.|   .|.|.:|.
Mouse   559 FNCPIIEVYGRTFPVQEYFLEDCIQMTQFIPPPKD-KKKKDKEDDG---GEDDD---ANCNLICG 616

  Fly   617 DKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGD 681
            |:|..:|:.:|:.|:|.:..|||:||||.:|::.|:|||:||||||||||:.:.|.|:|.:.||
Mouse   617 DEYGPETKLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLENNSHFG- 680

  Fly   682 TSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSH 746
            :.:|||||.||||||:||||||:|||:||||:|||||||||||||:|:|:|||.||.::||||:|
Mouse   681 SHRYQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAH 745

  Fly   747 NNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKL 811
            ||:|:|||||||||||||||||||||||||||.|||||||..||.::|||||||||||:||:|||
Mouse   746 NNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFDRLETHMTPEMFRTPLHEIALSIKL 810

  Fly   812 LRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGA 876
            ||||.|..||:||:||||:|||||||..|||:..||||||||||||:||:||||||.||||::|.
Mouse   811 LRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGC 875

  Fly   877 VFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEH 941
            :|...|.:..: |.::.|.|.|..:  .:||....:..:|.:.|||||::...|.|...:..||.
Mouse   876 IFYVGDAVCTI-SAATCFPEPFISE--GKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMSGEE 937

  Fly   942 MEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCL 1006
            .|.|||:.|.|.|:|:.:.|:||.||.::|..:||||:|:::.....  .|.|..|||.::||..
Mouse   938 AEIRFCEQKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTN--TGPDNNLDVVISLLAF 1000

  Fly  1007 GLYPNICVHKEKRKVLTTESKAALLHKTSVNC--SNLAVTFPYPFFVFGEKIRTRAVSCKQLSMV 1069
            |:|||:|.||||||:||||.:.||:||:||||  |:..:.:|.|||||||||||||:|.|.:::|
Mouse  1001 GVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLV 1065

  Fly  1070 SPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEE 1134
            :|||::||.|:|:. :...||.:|:|:...|..|.||.|.||:.|:|.|:......|:.|.:|:.
Mouse  1066 TPLQLLLFASKKVQ-SDGQIVFIDDWIRLQISHEAAACITALRAAMEALVVEVSKQPNIISQLDP 1129

  Fly  1135 PYAQLVKVVKDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGR------------- 1186
            ....::..::.:...||.  |:....|     |.::.||..|||..|::.|.
Mouse  1130 VNEHMLNTIRQISRPSAA--GINLMIG-----SVRYGDGPRPPKMARYDNGSGYRRGYGGGGYGG 1187

  Fly  1187 ------FTNSSFGRR-GNGRTFGGGYGNNGGGYGNNGGGYGNIGGGY------------------ 1226
                  :.:..||.. |:|..||||:.:.|||:|:.|||:|:.|||:
Mouse  1188 GGYGGGYGSGGFGGGFGSGGGFGGGFNSGGGGFGSGGGGFGSGGGGFGGGGGGFSGGGGGGFGGG 1252

  Fly  1227 -GNNAGGYGNNGGYGNNGGGYRNNGGGY-GNNGGGYGNKRGGFG----------------DSFES 1273
             |...||:|.:||:|:.||||...|||| |..|||||...||:|                :|:..
Mouse  1253 RGGGGGGFGGSGGFGSGGGGYGVGGGGYGGGGGGGYGGGSGGYGGGGGGYGGGEGYSISPNSYRG 1317

  Fly  1274 N-RGSGGGFRNGDQGGRWGNF 1293
            | .|.|||:|.|.|||...||
Mouse  1318 NYGGGGGGYRGGSQGGYRNNF 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	39/63 (62%)
		DSRM	170..240	CDD:214634	43/69 (62%)
		DEXDc	393..569	CDD:214692	120/175 (69%)
		DEXDc	402..542	CDD:238005	97/139 (70%)
		ATP-synt_B	<584..644	CDD:304375	21/59 (36%)
		Helicase_C	643..772	CDD:278689	93/128 (73%)
		HA2	842..926	CDD:214852	40/83 (48%)
		OB_NTP_bind	974..1078	CDD:285018	57/105 (54%)
Dhx9	XP_011246220.1	DSRM_DHX9_rpt1	3..71	CDD:380683	43/67 (64%)
		DSRM_DHX9_rpt2	181..255	CDD:380684	46/73 (63%)
		DEXHc_DHX9	333..566	CDD:350730	140/232 (60%)
		HrpA	337..>1055	CDD:224557	430/730 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838208
Domainoid	1	1.000	220	1.000	Domainoid score	I2620
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1039
Inparanoid	1	1.050	1274	1.000	Inparanoid score	I167
Isobase	1	0.950	-	0	Normalized mean entropy	S1936
OMA	1	1.010	-	-		QHG45656
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006547
OrthoInspector	1	1.000	-	-		oto95000
orthoMCL	1	0.900	-	-		OOG6_105518
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2487
SonicParanoid	1	1.000	-	-		X4785
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740