Protein Alignment mle and mle

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_316626.5
• Gene: mle / 1277182
• VectorBaseID: AGAMI1_002111
• Length: 1320
• Species: Anopheles gambiae
• Alignment Length: 1348
• Identity: 768/1348 - (56%)
• Similarity: 945/1348 - (70%)
• Gaps: 95/1348 - (7%)

  Fly     1 MDIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFV 65
            ||:||||..:|.|:..||.||:|..|||:|||||||||:....||||||||||||:||||.||||
Mosquito    10 MDMKSFLLCWCQKNVCEPAFDVRPLGPKHRQRFLCEVRIPGINYIGVGNSTNKKDSEKNASRDFV 74

  Fly    66 NYLVRVGKLNTNDVPADAGASGGG-PRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHD 129
            |||||:||:....||.|..|..|| .|....|..||.....|..:|.....|||||:||||
Mosquito    75 NYLVRIGKVPEGSVPQDPSAPAGGIDRADAAGPSMARAPAGQGNIFMKGFVPQDLGQAYRP---- 135

  Fly   130 GGDGGNRY--SVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPV 192
                   |  |..|..:||.:|..||:.||||:|||||||||||.:||.:.|.:.|:.::|||.:
Mosquito   136 -------YVPSKEDIKREQDNMEAAESLDVNASIHGNWTIENAKSKLNQWLQHHKIKAEFKYTSI 193

  Fly   193 GPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKK-KK 256
            ||:||:||:||:.:||..||||:|.|||||||:||||||||||:|||:||.|||.|:|:||. ..
Mosquito   194 GPDHAKSFIAEMIVYVRELNRTITGRESGSNKQSASKSCALSLIRQLYHLGVIEAFTGSLKSATA 258

  Fly   257 DEQLKPYPVKLSPNLINKIDEVIKGLDL-PV-VNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEK 319
            .|||..||||:|..|..::.|.:..:.: || |||   ..|.....:.|:.....:....|....
Mosquito   259 SEQLAAYPVKISNQLAQRVHETLLEMGVQPVKVNP---AAENPKESVSLLHPSDDVHFKPQSTNL 320

  Fly   320 RQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKL 384
            .|.:|||.|:||..|||.|..||||||.|||.|:|.||.|.......|.::|.|.::.:..||||
Mosquito   321 HQPASVISWSPPVPNWNAWLGCNIDEGYLATASLDQLSEDLLNESSSRLKDDLELQKSMRTREKL 385

  Fly   385 PIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISV 449
            ||:|||..|:.|||::|||:|||||||||||||||:||:|||.||||.|.|:.||||||||||||
Mosquito   386 PISAMRKPIMEAINEHPVVLIRGNTGCGKTTQIAQFILEDYINSGQGAYCNVCVTQPRRISAISV 450

  Fly   450 AERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAGLRGVSHIIVDEIHERDV 514
            :||:|.||||.||.||||||||:||.|||||:|||||:||||||||.|||||||:||||||||||
Mosquito   451 SERIANERCENLGVTVGYSVRFDSVLPRPYGSILFCTIGVLLRKLEGGLRGVSHVIVDEIHERDV 515

  Fly   515 NSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTD 579
            ||||:||:|||||.|||||.||||||||||:.||:|||.|||||||||||||:|.||||.|::..
Mosquito   516 NSDFILVVLRDMVHTYPDLRVILMSATIDTSLFSRYFGDCPVLEVPGRAFPVEQLFLEDCIELLK 580

  Fly   580 FVPS----AESRRKR-KEVEDE------EQLLSEDKDEAEI-NYNKVC-EDKYSQKTRNAMAMLS 631
            |.||    ...|||| |:.||:      |.    |.|..|. |.|:|. |.|||.:|:.||||:.
Mosquito   581 FRPSPPEGGAGRRKRGKDGEDDGGDGGGEC----DADMPECGNLNEVIDESKYSPQTKQAMAMMI 641

  Fly   632 ESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQ-NTNIFGDTSQYQILPCHSQIP 695
            |:|..|||:.||:.::..:..|||:||||.|||:|||||:.|| ..|:.       :||.|||:|
Mosquito   642 EADTPFELITALVDYVDQQGRPGAVLVFLAGWNMIFALMRQLQPRQNLV-------VLPLHSQLP 699

  Fly   696 RDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKT 760
            |::|||||....:. .|:||:||||||||||||:|:|||.|||||||||||||:|:||||||::|
Mosquito   700 REDQRKVFNHYGQR-RKVILATNIAETSITIDDVVYVIDTCKARMKLFTSHNNMTNYATVWAART 763

  Fly   761 NLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKAL 825
            ||||||||||||.||.||||||||||..||:|||||||||||||:||:|||||||:|..|||||:
Mosquito   764 NLEQRKGRAGRVSPGMCFTLCSRARFAKLEENLTPEMFRTPLHELALSIKLLRLGAIGKFLSKAI 828

  Fly   826 EPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASY 890
            ||||:||||||||||:||||||..::|||.||:||||||||||||||||..:||..|.:..||:|
Mosquito   829 EPPPLDAVIEAEVLLKEMRCLDEEEQLTPFGRILARLPIEPRLGKMMVLSTLFGLCDTLTTMAAY 893

  Fly   891 SSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMS 955
            |.||||||.|::|||||.||||||||..|||:|||:.|.:||.:::..||..|.||||||||||.
Mosquito   894 SGTFSEVFLLELGQRRLMNHQKALSGQTCSDYVAMLTAFEMWSKKRAIGEEAEMRFCDWKGLQMP 958

  Fly   956 TMNVIWDAKQQLLDLLQQAGFPEECMISHEVD-ERIDGDDPVLDVSLALLCLGLYPNICVHKEKR 1019
            |:..|.:||:||::.|..||||::.|:....| |..|.|   |::::||||:|||||:|.|||||
Mosquito   959 TLRSIAEAKKQLIENLCLAGFPQDTMMPLRFDSENPDSD---LEMAMALLCIGLYPNVCYHKEKR 1020

  Fly  1020 KVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDL 1084
            :||||||:|||:|||||||||...||||||||||||||||||||||:|||:|:.::|||.:|::.
Mosquito  1021 RVLTTESRAALMHKTSVNCSNAPTTFPYPFFVFGEKIRTRAVSCKQMSMVTPIHLLLFGCKKVEW 1085

  Fly  1085 AANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVK 1149
             .:..||:|||||.:::|..||.|.||:|.|::|:....:||.....|:..:.:|::|:|:||..
Mosquito  1086 -CHGSVRIDNWLNLNMDPCDAAMILALRPCLQELLVRISENPESTTSLDGKHVKLLQVIKELCAF 1149

  Fly  1150 SAGDFGLQRE------SGILPHQ---SRQFSDGGGPPKRGRFETG----------RFTNSSFGRR 1195
            :|||..::|.      .|:..||   .|...|.||....||...|          ::..:....|
Mosquito  1150 NAGDHEIERPKGSTFGQGVRSHQPKVPRMDEDDGGRGNYGRMGGGGGGGGNSGMYQYGGNGGNFR 1214

  Fly  1196 GNGRTFGGGYGNNGGGYGNNG--GG------YGNIGGGYGNNAGGY----GNNGG-YGNNGGGYR 1247
            |:|..:|.||||.|||.|..|  ||      |.|.|...||:..||    |:||| ||..||.|:
Mosquito  1215 GDGNRYGSGYGNGGGGGGGGGYDGGSRSNFRYFNSGANPGNSGDGYMRGGGDNGGQYGGGGGNYQ 1279

  Fly  1248 NNGGGYGNNG---GGY-GNKRGGFGDSFESNRGSGGGFRNGDQG-GRW 1290
              |.|||.|.   ||| |..|||:|..     |.|||..|..:| |.|
Mosquito  1280 --GSGYGGNSGYRGGYQGGNRGGYGGG-----GYGGGNNNYGRGQGGW 1320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	47/67 (70%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	47/73 (64%)
		DEXHc_DHX9	326..559	CDD:350730	168/232 (72%)
		HrpA	378..>889	CDD:441249	360/524 (69%)
		OB_NTP_bind	1002..1079	CDD:400182	61/76 (80%)
mle	XP_316626.5	None