Protein Alignment mle and ath

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_556838.4
• Gene: ath / 1276808
• VectorBaseID: AGAMI1_006394
• Length: 715
• Species: Anopheles gambiae
• Alignment Length: 756
• Identity: 210/756 - (27%)
• Similarity: 343/756 - (45%)
• Gaps: 134/756 - (17%)

  Fly   340 ACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVI 404
            |..:|.|..:..|  .|...|.||...:.|...:       |..|||.::|..::..:..:..:|
Mosquito    40 AVTMDSGLSSRNS--SLGNQYSRSYMKQEQAKQQ-------RLSLPIYSVRKSLMEMVRKSSTII 95

  Fly   405 IRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSV 469
            :.|.||.|||||:.|:|.:    :|..|...|.:|||||::||:||:.||:|....|||.|||:|
Mosquito    96 VLGETGSGKTTQMPQFIYE----AGLNGDKMIAITQPRRVAAITVAKWVAQEMGTNLGDLVGYTV 156

  Fly   470 RFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRD-----MV 527
            |||.: ......:.:.|.|:|.|:.  :..||..:.||:||:|||.:.:|.||.:::.     .:
Mosquito   157 RFEDM-TSENTQVKYMTDGILCREALSDRQLRNYNVIILDEVHERTIATDVLLGVVKKAQQIRAL 220

  Fly   528 DTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKE 592
            .....|.||:||||:|...|:.||..||::.:.||.:.|:      :.||.:
Mosquito   221 KRMTPLKVIIMSATMDCDHFASYFSDCPIVYLQGRTYQVK------VYQMVE------------- 266

  Fly   593 VEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAIL 657
                           :::|.:.|     .||                    ::.|......|.:|
Mosquito   267 ---------------KMHYIEAC-----LKT--------------------VVEIHQTQPAGDVL 291

  Fly   658 VFLPGWNLIFALM-KFLQNTNIFG-DTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIA 720
            |||.|...|.|.: |..:....|. |..:..:.|.::.:|:::|..||...|..|.|:|.:||||
Mosquito   292 VFLTGQEEIEATVGKMRRLAKSFSPDLPKLAVHPMYAALPQNQQLDVFNAAPGNVRKVIFATNIA 356

  Fly   721 ETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRAR 785
            ||||||:.|.:|:|..:|:::.:.....:......|.|:....||.|||||:..|.|:...|:..
Mosquito   357 ETSITINGIRYVVDCGRAKVRSYDPITGMDMLKVSWISQAQAHQRTGRAGRLSDGVCYRTYSKEV 421

  Fly   786 FQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDA-- 848
            :..||....||:.|.   .||.||..|.:..:::.....::.||.:|::..   |.|::.|:|
Mosquito   422 YGHLEKMTMPEILRC---NMAATILNLLVMGVNYKDFDFIDKPPEEAIVGG---LLELKALNAIS 480

  Fly   849 ---NDELTPLGRLLARLPIEPRLGKMMVLGAVFGC-ADLMAIMASYSSTFSEVFSLDIGQRR--L 907
               |..||.||..:||.|::|:..||::....||| .:::.|:|..|.  ..||:..:.:|.  |
Mosquito   481 SVENPILTALGTKMARFPLDPKYSKMLLSAPKFGCLEEMLTIIAMLSG--ENVFTNSVHKREQML 543

  Fly   908 ANHQKALSGTKCSDHVAMI-VASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLL 971
            ..|.|...  :..||:.:: |.::...|.|.:      .:|....|....:..:...::||.::.
Mosquito   544 IAHSKFFD--RSGDHITLLNVFNEFKTRAKPK------VWCFDNFLNERNLTHVASIREQLSEIC 600

  Fly   972 QQAGFPEE-CMISHEVDERIDGDD--PVLDVSLALLCL--GLYPNICVHKEKRKVLT-TESKAAL 1030
            :....|.. |           |.|  ||..      ||  ||:.||...:.....|| |.:..|.
Mosquito   601 KALDLPSSTC-----------GKDTTPVAK------CLLTGLFANIATKQPDHLYLTSTSALKAR 648

  Fly  1031 LHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSP 1071
            :|.:|..|..    |..|..|:.|.:.||....:.::.:.|
Mosquito   649 IHPSSAVCGK----FRPPVVVYTELVATRLNYLRNVTEIDP 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	79/225 (35%)
		HrpA	378..>889	CDD:441249	158/525 (30%)
		OB_NTP_bind	1002..1079	CDD:400182	20/73 (27%)
ath	XP_556838.4	None