Protein Alignment mle and kz

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_312236.6
• Gene: kz / 1273275
• VectorBaseID: AGAMI1_001604
• Length: 1224
• Species: Anopheles gambiae
• Alignment Length: 1235
• Identity: 283/1235 - (22%)
• Similarity: 478/1235 - (38%)
• Gaps: 364/1235 - (29%)

  Fly   140 IDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYK-----QTNNIRDDYKYTPVGPEHARS 199
            :::|.:|:...|..:..:.:.:    .::.:|:.|:.::     ||..::..:|....|..:..:
Mosquito    75 LEKIVDQKKKKENRSSLIASLV----AVQASKDDLSGFRKLSEVQTKGLKQHFKEQKYGVTYVNN 135

  Fly   200 FLAELSIYVPALNRTVTARESGSNK-KS--ASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLK 261
                             |:|:|..| ||  .|:...|:|:||....:| |...|
Mosquito   136 -----------------AKEAGVAKIKSLVGSRRKRLALLRQAGPASV-EEVEG----------- 171

  Fly   262 PYPVKLSPNLINKIDEVIKGLDLP--VVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESS 324
                :..||::        ||:.|  ..:....::|.:|..          .:.|::.|..|||:
Mosquito   172 ----EYDPNVV--------GLNDPSSSEDESEEEVEEEGEE----------GNEQEEEESEQESA 214

  Fly   325 VIPWAPPQANWNTWHACNIDEGELATTSI-DDLSMDYERS-LRDRRQNDNEYRQ----------- 376
                   |.:.|.    .:|:.:....|| ::.|...|.: ..|.:|.:.|..:
Mosquito   215 -------QEDENE----EVDKNQPEQESITEESSKKVENAPPEDVKQPNGEKEKPTVVDRKPATY 268

  Fly   377 --------FLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGY 433
                    ....|.||||......|:..|::|.:.|:.|.||.||||||.|::.:    :|.|..
Mosquito   269 IHVERDPAIQAARLKLPILGEEQIIMETISENKITILAGETGSGKTTQIPQFLYE----AGYGER 329

  Fly   434 ANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFE-SVFPRPYGAILFCTVGVLLRKLEAG 497
            ..|.||:|||::|:|:::|||.| .....|.|.|.:|:| :|..|.  .|.|.|.||||:::|..
Mosquito   330 GLIGVTEPRRVAAVSMSKRVAHE-MNLSTDVVSYLIRYEGNVTDRT--KIKFMTDGVLLKEIEVD 391

  Fly   498 --LRGVSHIIVDEIHERDVNSDFL------LVILRDMVDTYPDLHVILMSATI---DTTKFSKYF 551
              |...|.||:||.|||.|.:|.|      :|.||:.....| |.||:||||:   |.|:..|.|
Mosquito   392 FLLNKYSCIILDEAHERSVYTDILMGLLSRIVRLREKRGNNP-LRVIIMSATLRVQDFTENKKLF 455

  Fly   552 -GICPVLEVPGRAFPV-------------QQFFLEDI---------------------------- 574
             ...||:.:..|.|||             ::.||:.:
Mosquito   456 LDTPPVINIDSRQFPVTVHFNKTTPDDYLREAFLKTVKIHTKLPDGGILVFLTGQKEVNTMVRKL 520

  Fly   575 IQMTDFVPSAESRRKRKEV-EDEEQLLSEDKDEAEINY-----NKVCEDKYSQK-TRNAMAML-- 630
            .:|.......|..|..|:| |.:|:::.:::||.:..|     :|..:.|.|:: .|:.:.:|
Mosquito   521 RKMFPLRGDKEGVRTGKKVDEKKEEVVRDEEDEFDNVYRGKPAHKPPKAKSSKRQKRDQLPVLPQ 585

  Fly   631 -------------------SESDVSFEL-------------LEALLMHIKSKNIPGAILVFLPGW 663
                               .|:|.:.||             |.|.:..::...         |.|
Mosquito   586 INLDAYDLPHVDDTEGDRAEENDTASELDSDDDDDELNAANLSASVSELRKSQ---------PLW 641

  Fly   664 NLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDD 728
                                   :||.:|.:..|:|:.:|:|.|||....:::||:||||:||.|
Mosquito   642 -----------------------VLPLYSMLSPDKQQLIFQPPPEGARLCVVATNVAETSLTIPD 683

  Fly   729 IVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDN 792
            |.:|:|..:.:.||:.....:|::...:.||.:..||.||||||.||.|:.|.|.|.| ....:.
Mosquito   684 IKYVVDTGRQKTKLYDKTTGVTAFVVTYTSKASANQRAGRAGRVAPGHCYRLYSSAVFNDEFVEF 748

  Fly   793 LTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAV--IEAEVLLREMRCLD-------- 847
            ..||:.:.|:..:.|.:|.:.:..:.:|..    |.|.|.|  :.||..|.::..|:
Mosquito   749 APPEVQQKPVDGLMLQMKCMGIDKVLNFPF----PSPPDPVQLMSAEQRLLQLGALEQVIVRNGG 809

  Fly   848 ----ANDEL---TPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQR 905
                .|..|   |.|||.:|..|:.||.|||:.|.........:..:.:..|.
Mosquito   810 QKVQKNQTLTRVTELGRTMAAFPVAPRFGKMLALSHQHALLPYVICLVAALSV------------ 862

  Fly   906 RLANHQKALSGTKCSDHVAMIVASQMWRREKQ----------------------RGEHMEAR--- 945
                 |:.|.....|:......:.:.||::::                      ..||..::
Mosquito   863 -----QEVLEEVSLSEEANNTESGKRWRQKRKIWAGTGESLLLGDPMILLKAVGAAEHAHSKGVL 922

  Fly   946 --FCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLA------ 1002
              ||...|:::..:..|...:.||               ::||:..:.|.:..:|..:|
Mosquito   923 EEFCTENGIRLKAIREIRKLRIQL---------------TNEVNANLLGMNLAVDPDMAPPTATQ 972

  Fly  1003 ------LLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPY---PFFVFGEKIRT 1058
                  ||.:|....|.     ||:..::.|.    ||.......|...|.   |.|:....:..
Mosquito   973 IRLLRQLLLIGNADQIA-----RKLPESDIKL----KTDARKLKHAYNLPMIDEPVFLHASSVLR 1028

  Fly  1059 RAVS---CKQ--LSMVSPLQVILFGSRKIDLAANNIVRVD-NWLNFDIEPELAAKIGALKPALED 1117
            |...   |.|  ...:.|..|...||.|..:....|..:: :||     |:....:......||:
Mosquito  1029 REQPEWVCYQEAYEAIVPGVVGEEGSDKTKMFVRGITAIEPDWL-----PKFVPNVCNAIDVLEE 1088

  Fly  1118 LITVACDNPSDILRLE----------EPYAQLVKVVKDL--CVKSAGDFGLQRESGILPHQSRQF 1170
            .|..|.:..:|.:...          |..|.:|::.|::  | |....|.||   ||:..|.:.|
Mosquito  1089 PIPPAYNAATDTIECHVRATFGKTSWELPASVVEMPKNMLRC-KYLLKFILQ---GIVFKQLKPF 1149

  Fly  1171  1170
            Mosquito  1150  1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	17/81 (21%)
		DEXHc_DHX9	326..559	CDD:350730	87/266 (33%)
		HrpA	378..>889	CDD:441249	176/623 (28%)
		OB_NTP_bind	1002..1079	CDD:400182	19/96 (20%)
kz	XP_312236.6	None