Protein Alignment mle and TDRD9

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_694591.2
• Gene: TDRD9 / 122402
• HGNCID: 20122
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 916
• Identity: 278/916 - (30%)
• Similarity: 422/916 - (46%)
• Gaps: 187/916 - (20%)

  Fly   294 IELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSM 358
            :||.|.|.......:|.:..:||        |.|.|.|.|          ....||.......:.
Human    23 VELLGAPPAFPAGAAREEVQRQD--------VAPGAGPAA----------QAPALAQAPARPAAA 69

  Fly   359 DYERSLRDRR---QNDNEYRQFLEFRE------------------------------------KL 384
             :||||..|.   :..|:||| ||.:|                                    .|
Human    70 -FERSLSQRSSEVEYINKYRQ-LEAQELDVCRSVQPTSGPGPRPSLAKLSSVTCIPGTTYKYPDL 132

  Fly   385 PIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISV 449
            ||:..:.|:::.|..|.||||.|.||.||:||:.|||||.|:  .:..|.:|.|||||:|.|.|:
Human   133 PISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQYILDHYV--QRSAYCSIVVTQPRKIGASSI 195

  Fly   450 AERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEA--GLRGVSHIIVDEIHER 512
            |..:::||...||..|||.|..|.:.... ..:::.|.||||:|:.:  .|...:|||:||:|||
Human   196 ARWISKERAWTLGGVVGYQVGLEKIATED-TRLIYMTTGVLLQKIVSAKSLMEFTHIIIDEVHER 259

  Fly   513 DVNSDFLLVILRDMVDTYPD-LHVILMSATIDTTKFSKYFGICPV---------LEVPGRAFPVQ 567
            ....||||:::|.::.|... :.|:||||||...:|:.||.: ||         .||.|:...|:
Human   260 TEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFAV-PVQNKMNPAYIFEVEGKPHSVE 323

  Fly   568 QFFLEDI--IQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAML 630
            :::|.|:  |..:...|...          ||.::::|..|..::..::.:|...:::.|.
Human   324 EYYLNDLEHIHHSKLSPHLL----------EEPVITKDIYEVAVSLIQMFDDLDMKESGNK---- 374

  Fly   631 SESDVSFELLEALLMHIKSKNIPGAILVFLPGW---NLIFALMKFLQNTNIFGDTSQYQILPCHS 692
            :.|...|.|..:            ::||||||.   |.:..|:..|.:..:       |:.|.||
Human   375 AWSGAQFVLERS------------SVLVFLPGLGEINYMHELLTSLVHKRL-------QVYPLHS 420

  Fly   693 QIPRDEQRKVF-EPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVW 756
            .:..:||..|| .||| |..||||||||||:|:|:.|:.:|||.|..|..:.....|..|....|
Human   421 SVALEEQNNVFLSPVP-GYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSW 484

  Fly   757 ASKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHF 820
            ||||:..|||||||||..|:|:.|..:..: .::.|::.|||.|.||....|.:|||.:|.....
Human   485 ASKTSCNQRKGRAGRVSRGYCYRLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDMGEPRAL 549

  Fly   821 LSKALEPPPVDAVIEAEVLLREMRCL-------DAN---DELTPLGRLLARLPIEPRLGKMMVLG 875
            |:.||.||.:..:....:||:|:..|       |.|   .|||.|||:||:||:..:|||::|||
Human   550 LATALSPPGLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLG 614

  Fly   876 AVFGCAD---LMAIMASYSSTFSEVF--SLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRRE 935
            .||||.|   ::|...|..:.|:..|  .|| |.|...|    .||:..||.:|::.|.:.|:..
Human   615 HVFGCLDECLIIAAALSLKNFFAMPFRQHLD-GYRNKVN----FSGSSKSDCIALVEAFKTWKAC 674

  Fly   936 KQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERI-------DGD 993
            :|.||           |:.....:.|..    |:.:|.....|...:..|:..||       |..
Human   675 RQTGE-----------LRYPKDELNWGR----LNYIQIKRIREVAELYEELKTRISQFNMHVDSR 724

  Fly   994 DPVLD---------VSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPF 1049
            .||:|         :...:|....|||.....:..:.:.....|....||:|...::.   ||.|
Human   725 RPVMDQEYIYKQRFILQVVLAGAFYPNYFTFGQPDEEMAVRELAGKDPKTTVVLKHIP---PYGF 786

  Fly  1050 FVFGEKIRTRAVSCKQLSMVSPLQVILFGSRK--IDLAANNIVRVDNWLNFDIEPE--LAAKIGA 1110
            ..: :::::....|.|      ::.|:|...|  ::.:.|...|      |...|.  :|.|:..
Human   787 LYY-KQLQSLFRQCGQ------VKSIVFDGAKAFVEFSRNPTER------FKTLPAVYMAIKMSQ 838

  Fly  1111 LKPALE 1116
            ||.:||
Human   839 LKVSLE 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	94/283 (33%)
		HrpA	378..>889	CDD:441249	199/578 (34%)
		OB_NTP_bind	1002..1079	CDD:400182	15/76 (20%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..62		10/43 (23%)
		HrpA	130..>716	CDD:441249	222/643 (35%)
		DEXHc_TDRD9	132..315	CDD:350746	76/186 (41%)
		DEAH box. /evidence=ECO:0000250|UniProtKB:Q14BI7	254..257		2/2 (100%)
		Tudor_TDRD9	905..1005	CDD:410502