DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mle and Dhx57

DIOPT Version :9

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_001157231.1 Gene:Dhx57 / 106794 MGIID:2147067 Length:1388 Species:Mus musculus


Alignment Length:1007 Identity:341/1007 - (33%)
Similarity:502/1007 - (49%) Gaps:181/1007 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   271 LINKIDEVIKGL-------DLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPW 328
            |:.:..|::|.|       .:|.||.         ||:|....:|:         ......|:| 
Mouse   414 LLEEESEIVKLLTHTQHKYSVPPVNV---------PPVPSETRISK---------PAYRKPVVP- 459

  Fly   329 APPQANWNTWHACNIDEGELATTSIDDLSMD-----------------------YERSLR----- 365
                  .||:.:..:.|||..:...:|...|                       |:|..:     
Mouse   460 ------SNTFLSNQMLEGERLSELEEDADEDEGPASIIVENESYVNLKKRSYKRYDRPAKSLFAE 518

  Fly   366 --------DRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYIL 422
                    ..:|...::...|:.|:.||....|..||..::.:.||:|.|.|||||||||.|:||
Mouse   519 NSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFIL 583

  Fly   423 DDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTV 487
            |:.:.......|||..||||||||||||||||:||.|::|.||||.:|.||| ......:|:||.
Mouse   584 DNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESV-KSSATRLLYCTT 647

  Fly   488 GVLLRKLE--AGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKY 550
            |||||:||  |.|:||:||||||:|||...|||||::|:|:|.....|.|||||||:|...||||
Mouse   648 GVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGLFSKY 712

  Fly   551 FGICPVLEVPGRAFPVQQFFLEDIIQMTDFV-------------------PSAESRRKRKEVEDE 596
            |..|||:.:|||||||.||||||.:.:|.:|                   .:..:|..::|||::
Mouse   713 FSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSPYMRSMKQIAKEKLKARHNRTAQEEVEED 777

  Fly   597 EQLLSEDKDEAE-----------------INYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALL 644
            .:|....:||.|                 |.|..|     |:.....|:::....|:.||:||||
Mouse   778 LRLSLHLQDEEESVKDTIPDQQLDFKQLLIRYKGV-----SKSVIKTMSVMDFEKVNLELIEALL 837

  Fly   645 MHI---KSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQ--ILPCHSQIPRDEQRKVFE 704
            ..|   |....|||:||||||...|..|.:.||:.::|.:...::  |.|.||.:..:||:.||.
Mouse   838 EWIVDGKHAYPPGAVLVFLPGLAEIKMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFV 902

  Fly   705 PVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRA 769
            ..|.||||||:|||||||||||||:|:|||..|.:.|.:.:...:.|....:.|:.|..||||||
Mouse   903 KPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRA 967

  Fly   770 GRVRPGFCFTLCSRARF--QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHF---LSKALEPPP 829
            |||..|.||.|.:...:  |.|:..| ||:.|.||.::.|.||:|.:.|.|:.   .|:.:|||.
Mouse   968 GRVASGVCFHLFTSHHYNHQLLKQQL-PEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPH 1031

  Fly   830 VDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTF 894
            :|::..::|.||::..|..:::|||||..||.||::.|:||:|:||::|.|.| .|:..:.|..|
Mouse  1032 IDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLD-PALTIAASLAF 1095

  Fly   895 SEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNV 959
            ...|.....::..||.:|.......||::|::.|.:.|:...:........:|....|...|:..
Mouse  1096 KSPFVSPWDKKEEANQKKLEFAFANSDYLALLCAYKGWQLSTKESARASYNYCRQNFLSGRTLQE 1160

  Fly   960 IWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVS--------------LALLCLGLYP 1010
            :...|:|..:||...||.:|.:.:.|:::|..|.|.|||.:              .|:||..|||
Mouse  1161 MASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYP 1225

  Fly  1011 NIC--------VHKEKRKVLTTESKAALL------------HKTSVNCSNLAVTFPYPFFVFGEK 1055
            |:.        ..|....|:..:.|:|.|            |.:|||..  ...|..|:.::.||
Mouse  1226 NVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSVNYQ--VRHFDSPYLLYHEK 1288

  Fly  1056 IRTRAVSCKQLSMVSPLQVILFGSRKIDLAANN---IVRVDN-WLNF-DIEPELAAKIGALKPAL 1115
            |:|..|..:..||||...::|||..::::....   :|.:|: |:.| ....::|..:..|:..|
Mouse  1289 IKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGAFVVSLDDGWIRFVAASHQVAELVKELRCEL 1353

  Fly  1116 EDLITVACDNPSDILRLEEPYAQLVKVVKDLC 1147
            :.|:.....|||                .|||
Mouse  1354 DQLLQDKIKNPS----------------MDLC 1369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM 4..68 CDD:214634
DSRM 170..240 CDD:214634
DEXDc 393..569 CDD:214692 105/177 (59%)
DEXDc 402..542 CDD:238005 86/141 (61%)
ATP-synt_B <584..644 CDD:304375 18/76 (24%)
Helicase_C 643..772 CDD:278689 62/133 (47%)
HA2 842..926 CDD:214852 29/83 (35%)
OB_NTP_bind 974..1078 CDD:285018 38/137 (28%)
Dhx57NP_001157231.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..154
UBA_DHX57 181..218 CDD:270502
RWD 246..419 CDD:368608 1/4 (25%)
HrpA 501..1298 CDD:224557 300/806 (37%)
DEVH box 669..672 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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