Protein Alignment mle and Dhx57

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001157231.1
• Gene: Dhx57 / 106794
• MGIID: 2147067
• Length: 1388
• Species: Mus musculus
• Alignment Length: 1007
• Identity: 341/1007 - (33%)
• Similarity: 502/1007 - (49%)
• Gaps: 181/1007 - (17%)

  Fly   271 LINKIDEVIKGL-------DLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPW 328
            |:.:..|::|.|       .:|.||.         ||:|....:|:         ......|:|
Mouse   414 LLEEESEIVKLLTHTQHKYSVPPVNV---------PPVPSETRISK---------PAYRKPVVP- 459

  Fly   329 APPQANWNTWHACNIDEGELATTSIDDLSMD-----------------------YERSLR----- 365
                  .||:.:..:.|||..:...:|...|                       |:|..:
Mouse   460 ------SNTFLSNQMLEGERLSELEEDADEDEGPASIIVENESYVNLKKRSYKRYDRPAKSLFAE 518

  Fly   366 --------DRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYIL 422
                    ..:|...::...|:.|:.||....|..||..::.:.||:|.|.|||||||||.|:||
Mouse   519 NSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFIL 583

  Fly   423 DDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTV 487
            |:.:.......|||..||||||||||||||||:||.|::|.||||.:|.||| ......:|:||.
Mouse   584 DNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESV-KSSATRLLYCTT 647

  Fly   488 GVLLRKLE--AGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKY 550
            |||||:||  |.|:||:||||||:|||...|||||::|:|:|.....|.|||||||:|...||||
Mouse   648 GVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGLFSKY 712

  Fly   551 FGICPVLEVPGRAFPVQQFFLEDIIQMTDFV-------------------PSAESRRKRKEVEDE 596
            |..|||:.:|||||||.||||||.:.:|.:|                   .:..:|..::|||::
Mouse   713 FSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSPYMRSMKQIAKEKLKARHNRTAQEEVEED 777

  Fly   597 EQLLSEDKDEAE-----------------INYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALL 644
            .:|....:||.|                 |.|..|     |:.....|:::....|:.||:||||
Mouse   778 LRLSLHLQDEEESVKDTIPDQQLDFKQLLIRYKGV-----SKSVIKTMSVMDFEKVNLELIEALL 837

  Fly   645 MHI---KSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQ--ILPCHSQIPRDEQRKVFE 704
            ..|   |....|||:||||||...|..|.:.||:.::|.:...::  |.|.||.:..:||:.||.
Mouse   838 EWIVDGKHAYPPGAVLVFLPGLAEIKMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFV 902

  Fly   705 PVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRA 769
            ..|.||||||:|||||||||||||:|:|||..|.:.|.:.:...:.|....:.|:.|..||||||
Mouse   903 KPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRA 967

  Fly   770 GRVRPGFCFTLCSRARF--QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHF---LSKALEPPP 829
            |||..|.||.|.:...:  |.|:..| ||:.|.||.::.|.||:|.:.|.|:.   .|:.:|||.
Mouse   968 GRVASGVCFHLFTSHHYNHQLLKQQL-PEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPH 1031

  Fly   830 VDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTF 894
            :|::..::|.||::..|..:::|||||..||.||::.|:||:|:||::|.|.| .|:..:.|..|
Mouse  1032 IDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLD-PALTIAASLAF 1095

  Fly   895 SEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNV 959
            ...|.....::..||.:|.......||::|::.|.:.|:...:........:|....|...|:..
Mouse  1096 KSPFVSPWDKKEEANQKKLEFAFANSDYLALLCAYKGWQLSTKESARASYNYCRQNFLSGRTLQE 1160

  Fly   960 IWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVS--------------LALLCLGLYP 1010
            :...|:|..:||...||.:|.:.:.|:::|..|.|.|||.:              .|:||..|||
Mouse  1161 MASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYP 1225

  Fly  1011 NIC--------VHKEKRKVLTTESKAALL------------HKTSVNCSNLAVTFPYPFFVFGEK 1055
            |:.        ..|....|:..:.|:|.|            |.:|||..  ...|..|:.::.||
Mouse  1226 NVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSVNYQ--VRHFDSPYLLYHEK 1288

  Fly  1056 IRTRAVSCKQLSMVSPLQVILFGSRKIDLAANN---IVRVDN-WLNF-DIEPELAAKIGALKPAL 1115
            |:|..|..:..||||...::|||..::::....   :|.:|: |:.| ....::|..:..|:..|
Mouse  1289 IKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGAFVVSLDDGWIRFVAASHQVAELVKELRCEL 1353

  Fly  1116 EDLITVACDNPSDILRLEEPYAQLVKVVKDLC 1147
            :.|:.....|||                .|||
Mouse  1354 DQLLQDKIKNPS----------------MDLC 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	114/270 (42%)
		HrpA	378..>889	CDD:441249	246/558 (44%)
		OB_NTP_bind	1002..1079	CDD:400182	29/96 (30%)
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD_DHX57	243..425	CDD:467661	3/10 (30%)
		zf_CCCH_4	305..323	CDD:465719
		HrpA	545..>1172	CDD:441249	260/634 (41%)
		DEVH box	669..672		2/2 (100%)
		OB_NTP_bind	1215..1312	CDD:400182	29/98 (30%)