DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx32

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001272959.1	Gene:	Dhx32 / 101437	MGIID:	2141813	Length:	751	Species:	Mus musculus

Alignment Length:	851	Identity:	188/851 - (22%)
Similarity:	342/851 - (40%)	Gaps:	192/851 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 DEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGN 408
            :||.||..       |.|.:..|.....:.|.:.|:.||:|||...:...:.::..|.||::.|:
Mouse    36 EEGVLACE-------DLELNPFDGLPYSSRYYKLLKEREELPIWKEKYSFMESLLQNQVVVVSGD 93

  Fly   409 TGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFES 473
            :.|||::|:.|:.. :|..|....:..:..||..:.:|:.:|.|||.|....:|..|||.:.||:
Mouse    94 SKCGKSSQVPQWCA-EYCLSIHYQHGGVICTQAHKQTAVQLALRVADEMDVNIGHEVGYVIPFEN 157

  Fly   474 VFPRPYGAIL-FCTVGVLLRKLEA----GLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDL 533
            .....  .|| :||..:|.|::.:    |..||  ||:|::|||.:.:|.||.:|:|::...|:|
Mouse   158 CCTTE--TILRYCTDDMLQREMMSNPFLGSYGV--IILDDVHERSLATDVLLGLLKDVLLARPEL 218

  Fly   534 HVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQ 598
            .:|:..:.:.|:|.|.|:|..||:||..: .||:..:|.
Mouse   219 KLIVNCSPLLTSKLSSYYGDVPVIEVRNK-HPVEVVYLS-------------------------- 256

  Fly   599 LLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW 663
              ...||                              |||.:..|:..|......|.::|||...
Mouse   257 --GAQKD------------------------------SFESVIRLIFEIHRSGEKGDVVVFLACE 289

  Fly   664 NLIFALMKFL--QNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEG-------VTKIILSTNI 719
            ..|....:.:  :.:|:..|.....::|.:.:    |:..:|.||.|.       ..:::|:|:.
Mouse   290 QDIEKTYELVCQEGSNLNPDVGDLVVIPLYPK----EKCSLFRPVDETEKRCQVYQRRVVLTTSC 350

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            .|:.|....:.||||:...|.:::.......|......|::..|.||...|....|..|.|.:.
Mouse   351 GESLIWSHTVKFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTE- 414

  Fly   785 RFQALEDNLTP----EMFRTPLHEMALTIKLLRLGSIHH--FLSKALEPPPVDAVIEAEVLLREM 843
              :....::.|    ||....|..|.|.:|.:.:..:..  |:::    |..:::::|...|..:
Mouse   415 --EFASKDMRPLKPAEMQEANLTSMVLFMKRVDIAGLGRCDFMNR----PAPESLMQALEDLDYL 473

  Fly   844 RCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLM---AIMASYSSTFSEVFSLDIGQR 905
            ..||.:..|:..|.:::..|::|:|.|.::....|.|.|.|   |.|.:..|.|..|
Mouse   474 AALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHV-------- 530

  Fly   906 RLANHQKALSGTKC--------SDHVAMIVASQMWRRE--KQRGEHMEARFCDWKGLQMSTMNVI 960
               .|....:...|        .||..:|.....::..  ....||....:|....|..|.:.:.
Mouse   531 ---PHGAEEAAVTCWKTFLHPEGDHFTLINVYNAYQDTVLNSANEHCVEMWCHDCFLSCSALRMA 592

  Fly   961 WDAKQQLLDLLQQAGFP--EECMISHEVDERIDGDDPVLDVSLALLCLGLYPNIC--VHKEKRKV 1021
            ...:.:||:::::...|  |....|.|     :|    |::..|||. |.:..|.  |......:
Mouse   593 DVIRAELLEIIKRIELPYAEPAFGSKE-----NG----LNIKKALLS-GYFMQIARDVDGSGNYL 647

  Fly  1022 LTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAA 1086
            :.|..:.|.||.    .|:.::|...|                        :.:||  .:..::.
Mouse   648 MLTHKQVAQLHP----LSSYSITKKMP------------------------EWVLF--HQFSISE 682

  Fly  1087 NNIVRVDNWLNFDIEPELAAKI------GALKPA-LEDLITVACDN-PSDILRLEEPYAQLVKVV 1143
            ||.:||.:    .:.|||..::      ..|.|: .:|::..|..: |::.:..::
Mouse   683 NNYIRVAS----AVSPELFMQLVPQYYFSNLPPSESKDILQQAAGHLPTETVNKDQ--------- 734

  Fly  1144 KDLCVK 1149
             |:|.|
Mouse   735 -DVCDK 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	59/180 (33%)
		DEXDc	402..542	CDD:238005	47/144 (33%)
		ATP-synt_B	<584..644	CDD:304375	5/59 (8%)
		Helicase_C	643..772	CDD:278689	30/137 (22%)
		HA2	842..926	CDD:214852	21/94 (22%)
		OB_NTP_bind	974..1078	CDD:285018	20/107 (19%)
Dhx32	NP_001272959.1	HrpA	19..687	CDD:224557	175/783 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900