DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx29

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_002729053.2	Gene:	Dhx29 / 100362324	RGDID:	2318361	Length:	1366	Species:	Rattus norvegicus

Alignment Length:	1105	Identity:	346/1105 - (31%)
Similarity:	564/1105 - (51%)	Gaps:	155/1105 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PLNHDGGDGGNRYSVIDR----IQEQ----RDMNEAEAFDVNAAIHGNWTIENAKE------RLN 175
            ||..||....| :::.::    .:|:    ::.::...||..|.   :||.::.|:      |.|
  Rat   328 PLATDGESALN-FNLFEKPAAATEEEKGKKKEPHDVRNFDYTAR---SWTGKSPKQFLIDWVRKN 388

  Fly   176 IYKQTNNIRDDYKYTPVGPE---HARSFLAELSIYV--PALNRTVTARESGSNKKSASKSCAL-- 233
            :.|..|   ..::..|||..   ..|...:|..:.|  |.:     ..|.|...:....:.||
  Rat   389 LPKSPN---PSFEKVPVGRYWKCRVRVVKSEDDVLVVCPTI-----LTEDGMQAQHLGATLALYR 445

  Fly   234 ----SLVRQLF---HLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRN 291
                ..|.||.   :.:|...:|...|||::              :||::         ...||:
  Rat   446 LVKGQSVHQLLPPTYRDVWVEWSDEEKKKEE--------------LNKME---------TNKPRD 487

  Fly   292 IKI-ELDGPPIPLIVNLSRIDSSQQDGEKRQ--ESSVIPWAPPQANWNTWHACNIDEGELATTSI 353
            :.| :|          ||::...||..::||  |:.......|:.:|...    :.:.:|:..|:
  Rat   488 LFIAKL----------LSKLKQQQQLQQQRQHPENKTETAEDPEESWENL----VSDEDLSALSL 538

  Fly   354 DDL-SMDYE--RSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTT 415
            :.. :.|.|  |:|..|.|:..:|::.|:.|::||:...|:.|:..:..:.||::.|.||.||:|
  Rat   539 EPTGAEDLEPVRNLFRRLQSTPKYQRLLKERQQLPVFKHRASIVETLKRHRVVVVAGETGSGKST 603

  Fly   416 QIAQYILDDYICSGQGG-YANIYVTQPRRISAISVAERVARERCEQLG---------DTVGYSVR 470
            |:..::|:|.:.:..|. ..||..||||||||:|:|.||    ||:||         ...||.:|
  Rat   604 QVPHFLLEDLLLNDCGARKCNIVCTQPRRISAVSLATRV----CEELGCEGGPGGRNSLCGYQIR 664

  Fly   471 FESVFPRPYGAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDL 533
            .||..... ..:|:||.|||||||:..  |..|||:||||:|||.|.||||||||::::....||
  Rat   665 MESRASES-TRLLYCTTGVLLRKLQEDGLLADVSHVIVDEVHERSVQSDFLLVILKEILQKRSDL 728

  Fly   534 HVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQ 598
            |:||||||:|:.|||.||..||:|.:.||::||:.|.||||::.|.|:...:|...:|.:|:||:
  Rat   729 HLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHLEDIVEETGFILEKDSEYCQKFLEEEEE 793

  Fly   599 L-LSEDKDEAEINYNKVC--------------EDKYSQKTRNAMAMLSESDVSFELLEALLMHI- 647
            : ::.......|...:.|              ..|||.:|:.|:..::...::.:|:..||:::
  Rat   794 ITINVTSKAGGIKKYQECIPVQSGASPELSPFYQKYSSRTQYAVLYMNPHKINLDLILELLVYLD 858

  Fly   648 KS---KNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEG 709
            ||   :||.||:|:||||...|..|...|.|...| .:.:||::..||.:...:|...|...|.|
  Rat   859 KSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRF-YSERYQLIALHSVLSTQDQAAAFMLPPPG 922

  Fly   710 VTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRP 774
            |.||:|:||||||.|||.|:|||||..:.:...:...:.::|....:.||.:..||:|||||||.
  Rat   923 VRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRD 987

  Fly   775 GFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVL 839
            ||||.|.:|.||:...:...||:.|.||.|:.|.|....|||...||||||:||....:..|..|
  Rat   988 GFCFRLYTRERFEGFLEYSVPEILRVPLEELCLHIMKCDLGSPEDFLSKALDPPQPQVISNAMNL 1052

  Fly   840 LREM-RCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIG 903
            ||:: .|..:..:|||||:.||.||:..::|||::.||:|||.:.:|.:|:. .|....|...||
  Rat  1053 LRKIGACEPSEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAV-MTEKSPFITPIG 1116

  Fly   904 QRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGE-HMEARFCDWKGLQMSTMNVIWDAKQQL 967
            ::..|:..|:......|||:.:..|...|::.:|.|. ..|..:|....|..:::..:.|.||:|
  Rat  1117 RKDEADLAKSSLAVADSDHLTIYNAYLGWKKAQQEGGFRSEISYCQRNFLNRTSLLTLEDVKQEL 1181

  Fly   968 LDLLQQAGFPEECMISHEVDERIDGDDPV--LDVSL--ALLCLGLYPNICVHKEKRKVLTTESKA 1028
            :.|::.|||.     |....|...|...:  .|::|  |:|..|||.::......:.|..||..|
  Rat  1182 MKLVRAAGFS-----SSTSWEGKKGPQALSFQDIALLKAVLAAGLYDSVGKIMCTKSVDVTEKLA 1241

  Fly  1029 ---------ALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDL 1084
                     |.:|.:||| .:|..   |.:.::.||:|...|..::.::::|..|:|||.   |:
  Rat  1242 CMVETAQGKAQVHPSSVN-RDLQT---YGWLLYQEKVRYARVYLRETTLITPFPVLLFGG---DI 1299

  Fly  1085 AANN---IVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDL 1146
            ...:   ::.||.|:.|....::|.....|:..::.::....:||.  :.||..  ::::::.:|
  Rat  1300 EVQHRERLLSVDGWIYFQAPVKIAVIFKQLRVLIDSVLRKKLENPK--MSLEND--KILQIITEL 1360

Fly 1147 1146
Rat 1361 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	18/86 (21%)
		DEXDc	393..569	CDD:214692	88/187 (47%)
		DEXDc	402..542	CDD:238005	73/151 (48%)
		ATP-synt_B	<584..644	CDD:304375	13/74 (18%)
		Helicase_C	643..772	CDD:278689	54/132 (41%)
		HA2	842..926	CDD:214852	29/84 (35%)
		OB_NTP_bind	974..1078	CDD:285018	31/116 (27%)
Dhx29	XP_002729053.2	HrpA	531..1314	CDD:224557	287/801 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820