Protein Alignment mle and dhx34

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001121459.1
• Gene: dhx34 / 100158553
• XenbaseID: XB-GENE-1009178
• Length: 1133
• Species: Xenopus tropicalis
• Alignment Length: 1088
• Identity: 287/1088 - (26%)
• Similarity: 459/1088 - (42%)
• Gaps: 268/1088 - (24%)

  Fly   164 NWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSAS 228
            ||...|.:.:|.     .....:..|.....|.::.|.    ::.....|....::.|...|..:
 Frog    11 NWDCPNTRRQLE-----ELFFSEQGYIKANSEDSKEFW----VFFDRFQRFQKMQKRGDKCKGRT 66

  Fly   229 KSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLP-VVNPRNI 292
            ..               |.:||:||                             ||| |.:||
 Frog    67 DK---------------EKYSGSLK-----------------------------DLPKVYDPR-- 85

  Fly   293 KIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLS 357
                      ..:|.|.|.|  :|.||.:.:.|..:.            :.|...:....:::..
 Frog    86 ----------YRINFSIIQS--KDVEKSRHNHVKEYR------------SRDCRSIPREKLEEFK 126

  Fly   358 MDYERSLR-DRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYI 421
            |.....|. .::|:..:..:..:.|..|||...:.:|::.::.:.||::.|:|||||:||:.||:
 Frog   127 MSVLHYLDFTQKQSFAKLVKLRKERSSLPIFQYKEKIISMVHKHQVVVVAGDTGCGKSTQVPQYL 191

  Fly   422 LDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCT 486
            |       ..|:.:|..||||||:.||:|:||..|...|.|..|||.:|||| ...|...|:|.|
 Frog   192 L-------AAGFGHIACTQPRRIACISLAKRVGFESLNQYGSKVGYQIRFES-SRSPATKIVFIT 248

  Fly   487 VGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSK 549
            .|:|||::  ::.|.....|||||:|||.::|||||.:||.::...|||.||||||||:...||.
 Frog   249 EGLLLRQIQRDSTLPQYQVIIVDEVHERHLHSDFLLGVLRQLLILRPDLKVILMSATINIKLFSG 313

  Fly   550 YFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKV 614
            ||...|||:||||.||:|..:..        :|..|:..|.::::....|          :..:.
 Frog   314 YFEQAPVLQVPGRLFPIQVIYQP--------IPQEETVSKSEKLDPRPYL----------HVLQA 360

  Fly   615 CEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIF 679
            .:.||....|                             |.:|:||.|...|.::.:.:|   ::
 Frog   361 IDHKYPPDER-----------------------------GDLLIFLSGVTEISSVQEAVQ---VY 393

  Fly   680 G-DTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLF 743
            . .|.::.:||.||.:...:|.|||:..|.||.|.|:||||||||:|||.:.||:|..|.:...|
 Frog   394 ATHTQRWIVLPLHSTLSIADQDKVFDLAPVGVRKCIISTNIAETSVTIDGVRFVLDSGKVKEMSF 458

  Fly   744 TSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALT 808
            .....:......|.|:.:.|||||||||..||.|:.|.:.:.:.|......||:.|..|..:.|.
 Frog   459 DPKAKMQRLQEFWISRASAEQRKGRAGRTGPGVCYRLYAESDYDAFSPYPVPEIQRVALDSLVLQ 523

  Fly   809 IKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMV 873
            :|.:.||:..||  ..:|.|.:.::..|...||:...||.|:||||:|:|||:||::..:|||::
 Frog   524 MKSMELGNPRHF--PFIEQPSMSSIETAIFYLRDQGALDINEELTPIGKLLAKLPVDVVIGKMLI 586

  Fly   874 LGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQR 938
            ||::|...:.:..:||..|..|.:.............:|.|. ::..|...::.....|.:.|..
 Frog   587 LGSLFSLVEPVLTIASALSVQSPILRNSTSNPEWGTARKPLE-SEHGDPFTLLNIFNEWVQVKAN 650

  Fly   939 GEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMI--------------------- 982
            ......::|..:||:...:..:.:.::|..:||:..|..||.:.
 Frog   651 QRSNSRKWCRRRGLEEQRLYEMANLRRQFKELLKDHGLLEENVAQRGDRNSRQRQHKERKELHQL 715

  Fly   983 --SHE-VDER---------------IDGDD---------------PVLDVSLAL----------- 1003
              .|| |::|               .||::               .:.||...|
 Frog   716 KRQHERVEKRKRKVLKLQDEGAGSSSDGEEQYHTEKHRKDRKDSIDIQDVKFKLRHNIHELHASS 780

  Fly  1004 -----------------LCLGLYPNICV-------HKEKRKVLTTESK-AALLHKTSV-NCS--- 1039
                             :|.||||.:.|       .|:..:|..|::| ..:||.|.| :|:
 Frog   781 STGQDLSSQEVSLLKLIVCHGLYPQLGVPDSFNSCRKDSDQVFHTKNKQGVVLHPTCVFSCNPEL 845

  Fly  1040 ---------------NLAVTFPYPFFVFGEKIRTR---AVSCKQLSMVSPLQVILFGSRKIDLAA 1086
                           |...:..:....|...:.|.   .|:|.:|   |.||..|..:|.||.:|
 Frog   846 LQVNSEEESAGNESGNKGQSSRHQIVAFVSLLETNKPYLVNCVRL---SALQGFLLLARCIDTSA 907

  Fly  1087 N--NIVRVDNWLNFDIE-PE----LAAKIGALKPALEDLITVACDNPS 1127
            :  .|| .|.|:..::: ||    |..:...|:.|||.|:....:.||
 Frog   908 DCCRIV-CDKWMEMNVDNPESALCLITEAVQLRVALEKLLKSRLEKPS 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	8/73 (11%)
		DEXHc_DHX9	326..559	CDD:350730	87/235 (37%)
		HrpA	378..>889	CDD:441249	184/513 (36%)
		OB_NTP_bind	1002..1079	CDD:400182	26/134 (19%)
dhx34	NP_001121459.1	HrpA	152..>616	CDD:441249	187/523 (36%)
		OB_NTP_bind	794..903	CDD:400182	26/111 (23%)