Protein Alignment mle and dhx57

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001163976.1
• Gene: dhx57 / 100124795
• XenbaseID: XB-GENE-976876
• Length: 1180
• Species: Xenopus tropicalis
• Alignment Length: 948
• Identity: 308/948 - (32%)
• Similarity: 471/948 - (49%)
• Gaps: 173/948 - (18%)

  Fly   143 IQEQRDMNEAEAFDVNAAIHGN----------WTI----ENAKERLNIYKQTNNIRDDYKYTP-- 191
            ::|..:..:.||| |..:|.|.          ||:    :...:||...|:.::.:|.::..|
 Frog   245 VEECLERRQEEAF-VLQSICGEKFVERIPNKVWTVGLEMDYLTKRLQKPKKKDSDKDLFQQMPRN 308

  Fly   192 -----VGPEHAR----------------------------SFLAELSIYVPALNR---TVTARES 220
                 :..|:.|                            :.|.||.:..|..|:   .......
 Frog   309 ICKYYMKGENCRFGSKCRFKHEAPKQNFKDESHLCANGNNNCLYELEVRFPKDNKYPYQAPLLAF 373

  Fly   221 GSNKKSASKSCALSLVRQLFH--LNVI---EPFSGTL---KKKKDEQLK-----------PYPVK 266
            .|..::.|..|.|.:...|:.  ||:.   :|...||   .:.:||.:|           |.|:.
 Frog   374 YSVNENLSMGCRLHITEYLYEKALNIAQTSDPAVYTLVSCLEDEDEIVKLLANTHHKYSIPPPLL 438

  Fly   267 LSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPI------------PLIVNLSRIDSSQQDG-E 318
            |:.....:.:.||. ::.||..        |.|.:            |:.:::|:.:.:.:|. :
 Frog   439 LTATSDTRKNPVIT-INKPVAP--------DKPSLLSYPSGARKGQKPIKMDISKPNDTDEDSLD 494

  Fly   319 KRQESSVIPWAPPQAN----------WNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNE 373
            ..:..||:......||          :|:..|...:..::.            :..|.::...|
 Frog   495 DLESESVLVENESYANLKKKQAKKYSFNSNKAVAAENAKIC------------KHYRAKKTTRN- 546

  Fly   374 YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYV 438
            |:..||.|:|||....:.:||..::...|:::.|.|||||||||.|:|||..:.......:||..
 Frog   547 YQSMLEERQKLPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNIIC 611

  Fly   439 TQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGV 501
            ||||||||||||||||:||.|::|.:|||.:|.||| ......:|:||.|||||:||..  |:.|
 Frog   612 TQPRRISAISVAERVAQERAERVGISVGYQIRLESV-KSAATRLLYCTTGVLLRRLEGDTTLQNV 675

  Fly   502 SHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPV 566
            :|::|||:|||...|||||::|:|::...|||.:||||||::...||.||..||||.:|||.|||
 Frog   676 THVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATLNAELFSCYFQDCPVLHIPGRTFPV 740

  Fly   567 QQFFLEDIIQMTDFV--------------PSAESRRKRK-----EVEDE-EQLLSEDKDEAEINY 611
            .|:||||.|..|.:|              |..:|.|.:|     |:.|| ||.:|   ....|..
 Frog   741 DQYFLEDAIAKTRYVLEDGSPYQRSSKQLPGPDSARGKKGNSYNELLDELEQQIS---SSLRIQD 802

  Fly   612 NKVCED--------------KYSQKTRNAMAMLSESD---VSFELLEALLMHIKSKN---IPGAI 656
            :|:.:|              :|:..:::.:..||..|   ::.:|:||||..|.:.:   .|||:
 Frog   803 SKIVKDSVPDQQLNVKELSVRYNGISKSVIKTLSSMDLDKINLDLIEALLEWIVNGDHSYPPGAV 867

  Fly   657 LVFLPGWNLIFALMKFLQNTNIFGD--TSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            ||||||...|..|...||:..:|.:  :.:..|.|.||.:..|||:.||...|.||||||:||||
 Frog   868 LVFLPGLAEIKTLYDQLQSNALFNNRRSKRCVIYPLHSSLSSDEQQSVFLKPPPGVTKIIISTNI 932

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            |||||||||:|:|||..|.|.|.:....::.|....|.|:.|..|||||||||..|.||.|.:..
 Frog   933 AETSITIDDVVYVIDSGKMREKRYDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSH 997

  Fly   785 RFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGS---IHHFLSKALEPPPVDAVIEAEVLLREMRC 845
            .:| .|.|...||:.|.||.::.|.||:|.:.|   :....::.:|||.::::..:::.|:::..
 Frog   998 HYQYQLLDQQLPEIQRIPLEQLCLRIKILEMFSECRLDLVFARLIEPPRMESLHASKIRLQDLGA 1062

  Fly   846 LDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANH 910
            |...::|||||..||.||::.|:||:|:.||:|.|.| .|:..:.|..|...|.....::..||.
 Frog  1063 LTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLD-PALTIAASLAFKSPFVCPWDKKEEANK 1126

  Fly   911 QKALSGTKCSDHVAMIVASQMWR---REKQRGEHMEAR 945
            :|....|..|||:|::.|.|.|.   :|..|..:...|
 Frog  1127 KKQEFATANSDHLALLQAYQAWSSVIKESSRAAYQYCR 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	17/115 (15%)
		DEXHc_DHX9	326..559	CDD:350730	102/244 (42%)
		HrpA	378..>889	CDD:441249	236/558 (42%)
		OB_NTP_bind	1002..1079	CDD:400182
dhx57	NP_001163976.1	UBA_DHX57	185..222	CDD:270502
		RWD_DHX57	246..424	CDD:467661	34/178 (19%)
		zf-CCCH_4	308..329	CDD:465626	2/20 (10%)
		HrpA	557..>1109	CDD:441249	233/556 (42%)