DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and dhx32a

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001189401.3	Gene:	dhx32a / 100006246	ZFINID:	ZDB-GENE-130613-6	Length:	728	Species:	Danio rerio

Alignment Length:	666	Identity:	148/666 - (22%)
Similarity:	266/666 - (39%)	Gaps:	127/666 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 GELATTSIDDLSM-----DYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVII 405
            |||.....|..::     |.|.:..|.....:.|.:.|:.|:.||:...|.|.:|.:.:|.::|:
Zfish     9 GELGKEEEDSENLFEFGDDLELNQFDGLPYSSRYYRLLQERKTLPVWKYRHEFMTLLENNQILIV 73

  Fly   406 RGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVR 470
            .|.|..||:|||.|:.. ::..|.|..:..:..:|.:|..|:.:|.|||.|....:|..:|||:.
Zfish    74 SGTTKTGKSTQIPQWCA-EFCLSAQYQHGVVVCSQIQRRQAVDLALRVADEMDVNIGHEIGYSIP 137

  Fly   471 FESVFPRPYGAIL-FCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPD 532
            .|:....  ..|| :||..:|||::.:.  |.....::||:.|||.|::|.||.:||:::...|:
Zfish   138 LETCCSN--DTILRYCTDDILLREMMSDPLLEQYGVVLVDQAHERTVSTDVLLGLLREVLLQRPE 200

  Fly   533 LHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEE 597
            |.::::||.........::|..|.|.:.                    .|||
Zfish   201 LRLVVLSAPPTPETLLTHYGSVPRLHLE--------------------APSA------------- 232

  Fly   598 QLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPG 662
                     .|:.::.                 |.|..||.....|.:.:.....||.:.|||.
Zfish   233 ---------GEVIHSS-----------------SSSSESFYSALRLALEVHRSREPGDVAVFLA- 270

  Fly   663 WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRK------------------VFEPV--- 706
                               |.|..:..|:. |.::..|.                  :..||
Zfish   271 -------------------TEQEVVCACNI-ITKEASRMSVSLGELLAVPMCSGHAGICPPVTES 315

  Fly   707 PEGVTKIILS-TNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAG 770
            |:...:|.:| :.:.:...::|.|.||||....:..::......:|......||...|.||...|
Zfish   316 PQMSRRIFVSCSQLEDLFWSVDSIAFVIDTGVEKRLVYNPRLRASSEVIRPISKCQAEMRKQLTG 380

  Fly   771 RVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLR-LGSIH-HFLSKALEPPPVDAV 833
            ..  |.||  |.......|...:.|.:..:.:...||.:|.:. .|..| ||:::    |..:.:
Zfish   381 ST--GKCF--CLYPEDVQLPAEIHPRILESNITSTALFLKRMEAAGVTHCHFINR----PDPEGL 437

  Fly   834 IEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVF 898
            ::|...|..:..||.:..|:.:|.:::.||:||::.|.::....|.||..|..:|:..:..|...
Zfish   438 MQALEELDYLAALDNDGNLSEMGIIMSELPLEPQMAKALLASCEFDCASEMLTIAAMLTAPSCFI 502

  Fly   899 SLDIGQ--RRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIW 961
            ...:|.  ..:..|.|.....  .||..:|.....::|.::.....:.::|:...|..:.:....
Zfish   503 EPPVGMLTEVMRCHMKFQHPE--GDHFTLINIYNTFKRSQREPYFSQEQWCEQYYLCCAALQTAD 565

  Fly   962 DAKQQLLDLLQQAGFP 977
            ..:.||.|:|::...|
Zfish   566 AIRSQLSDVLKRIELP 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	52/178 (29%)
		DEXDc	402..542	CDD:238005	47/142 (33%)
		ATP-synt_B	<584..644	CDD:304375	6/59 (10%)
		Helicase_C	643..772	CDD:278689	29/150 (19%)
		HA2	842..926	CDD:214852	20/85 (24%)
		OB_NTP_bind	974..1078	CDD:285018	1/4 (25%)
dhx32a	NP_001189401.3	HrpA	14..>610	CDD:224557	145/661 (22%)
dhx32a	NP_001189401.3	OB_NTP_bind	569..678	CDD:311586	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900