DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BubR1 and BUBR1

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	NP_001189668.1	Gene:	BUBR1 / 817921	AraportID:	AT2G33560	Length:	396	Species:	Arabidopsis thaliana

Alignment Length:	408	Identity:	111/408 - (27%)
Similarity:	184/408 - (45%)	Gaps:	49/408 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KENIQPLASGRNVSLLQASLSQDSTH--GQELLAQRKQMEEEVRTYKGADPLGAWYTFICWIEQS 69
            |||::||..||||.:|..:|...|.|  .:.|:.:|:.:.|.:..|:|.|||..|...|.|::::
plant    31 KENVRPLKRGRNVGILNHALKSHSDHQLRKNLIEKRRNLIEAIDEYEGDDPLSPWIECIKWVQEA 95

  Fly    70 YPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGTMLAD 134
            :|.||..|||..:..||:.||...|||:.|.|.:|:::::.|...|....|:.:..|.||...|.
plant    96 FPPGGECSGLLVIYEQCVRKFWHSERYKDDLRYLKVWLEYAEHCADAEVIYKFLEVNEIGKTHAV 160

  Fly   135 FYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANAVNQE 199
            :|||:|...:....::.|:|||.||:...|:|:|.|.:|:..|.... .|...:..|:....|.:
plant   161 YYIAYALHIEFKNKVKTANEIFNLGISRDAKPVEKLNDAYKKFMVRT-MRRSNTADEQEPKENND 224

  Fly   200 LNERR----LALQSLHGRRQQISNSITVGSIRTGAAVKSGLPGVVQVEPSTTTSRRNVGRNVEVF 260
            |..|.    |:....:.|||               |:.|..|...:::|: .:|:.......:..
plant   225 LPSRSFGTLLSRGDNNARRQ---------------ALGSSNPQAKKLKPN-QSSKTPFAIYADAV 273

  Fly   261 NDENSEGNIPISN-SETEVKSSLRSIIDSACSQENIKEPVAWNKANAKRHKHGKIFGSNASPDLG 324
            :|..| ||.|.|: |..|..|.|.....:..::||...|..|  |:.|..:...:....|:....
plant   274 SDTTS-GNQPESDKSRPEFGSWLMLGGRAERNKENNSLPRKW--ASFKVPQKPIVRTVAAASAST 335

  Fly   325 FDIHVDEQAMPPITNYERRLEQPFRFPTNFVAKNRPQEPWVTPVTIEDEPNASGLPCYNKCLLYP 389
            |::.|||:........:::.::.....:|.:..|..:|       |:.|..          ||..
plant   336 FEVFVDEEECTEEEEEKKKNDETISSSSNVLPLNGGRE-------IKKETE----------LLRQ 383

  Fly   390 RPNIEFSPEEYRAYSFLK 407
            .|...|.|.     |||:
plant   384 NPLRHFPPN-----SFLR 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	41/120 (34%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883
BUBR1	NP_001189668.1	Mad3_BUB1_I	64..185	CDD:285506	41/120 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	93	1.000	Domainoid score	I2569
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1411806at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14030
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920