DRSC/TRiP Functional Genomics Resources

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Protein Alignment BubR1 and BUB1B

DIOPT Version :10

Sequence 1:NP_477382.1 Gene:BubR1 / 35522 FlyBaseID:FBgn0263855 Length:1460 Species:Drosophila melanogaster
Sequence 2:NP_001202.5 Gene:BUB1B / 701 HGNCID:1149 Length:1050 Species:Homo sapiens


Alignment Length:1474 Identity:309/1474 - (20%)
Similarity:507/1474 - (34%) Gaps:514/1474 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQMEEEVRTYKGADPLGAWYTFICWI 66
            :::.:|||:|||..||.:|.||.:|:|:|.....|..|::..|.|:|.|.|.|||..|..:|.|.
Human    21 EWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWT 85

  Fly    67 EQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGTM 131
            ||:||.||..|.:.|:|.:.:...:.::||..|.|.:.|::|......:.::.|..::|.|||..
Human    86 EQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVS 150

  Fly   132 LADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVG-QRMLYSTGEEANA 195
            ||.|||:||..|:...|.||||.||:.|::.:|||||.|:..|..|...|. |.:|....||...
Human   151 LAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEE 215

  Fly   196 VNQELNERRLALQSLHGRRQQISNSITVGSIRTGAAVKSGLPGVVQVEPSTTTSRRNV------- 253
            |.:....:|..|..|..:.::.:.:   ..||.|.|:|:         ||.....:|.       
Human   216 VFESSVPQRSTLAELKSKGKKTARA---PIIRVGGALKA---------PSQNRGLQNPFPQQMQN 268

  Fly   254 GRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVAWNKANAKRHKHGKIFGSN 318
            ...:.|| |||::.......|:..|:..:...:..|  :||..:...||...:..|:..   |:.
Human   269 NSRITVF-DENADEASTAELSKPTVQPWIAPPMPRA--KENELQAGPWNTGRSLEHRPR---GNT 327

  Fly   319 ASPDLGFDIHVDEQAMPPITNYERRLEQPFRFPTNFVAKNRPQEPWVTPVTIEDEPNASGLPCYN 383
            ||      :......:|..|.|   :|:..|            :|.:||..||        |..|
Human   328 AS------LIAVPAVLPSFTPY---VEETAR------------QPVMTPCKIE--------PSIN 363

  Fly   384 KCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTGRVIRGIRCYPNFARYSKPQDLD 448
            ..|...:|..|                                                      
Human   364 HILSTRKPGKE------------------------------------------------------ 374

  Fly   449 ELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAAKWMEKRNVTVHGDFDMEETVCLPGNKM 513
            |.|     ||        .::.:..:..|.:.|:::..|  ||....| |:|..||         
Human   375 EGD-----PL--------QRVQSHQQASEEKKEKMMYCK--EKIYAGV-GEFSFEE--------- 414

  Fly   514 PRRKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIVKDIPSQVAPKIPESPCDQIDEPKIKIF 578
                 .....|||.:..:|.:.:....||:            :::..:|.|.      |.|:|..
Human   415 -----IRAEVFRKKLKEQREAELLTSAEKR------------AEMQKQIEEM------EKKLKEI 456

  Fly   579 EDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPFYDGDETCSTQMFNMFIKSQAVSTPKGT 643
            :.:...|..              :..||..||.:|                             |
Human   457 QTTQQERTG--------------DQQEETMPTKET-----------------------------T 478

  Fly   644 QKQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGTQSLATSGTTTKST 708
            :.|.                 |:.|.:.|..|.|.::.:......|||                 
Human   479 KLQI-----------------ASESQKIPGMTLSSSVCQVNCCARETS----------------- 509

  Fly   709 ITSTSSPGSNAVSKLGSKIEENTPGQMRLQRVISAGVSAVLSEPEKPGGDNFLRRELWEPNAPSV 773
                          |...|.:..|.        |.|.|...|.     .|.||..|....:.|:.
Human   510 --------------LAENIWQEQPH--------SKGPSVPFSI-----FDEFLLSEKKNKSPPAD 547

  Fly   774 PMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPIALPENSMDHGSLGAENCFSAPQLPTLEDE 838
            |               ||.||          .:.|:|:.:.|              ..:.:.||.
Human   548 P---------------PRVLA----------QRRPLAVLKTS--------------ESITSNEDV 573

  Fly   839 S-DLCGLFGKTPPKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVTG-NKLEAAPSISNLQDSFMC 901
            | |:|..|      |.|        :|.|:          ...:|| ..:...|   |.:|:  |
Human   574 SPDVCDEF------TGI--------EPLSE----------DAIITGFRNVTICP---NPEDT--C 609

  Fly   902 DLS----FVPETQPEAVAKSGAIQKFDIFLDDTQPKLTKSKPVALMVSSFDLDCTLPETQQVAIK 962
            |.:    ||.....|.::           |.|     ..|.|..|:... |||....|.||.|. 
Human   610 DFARAARFVSTPFHEIMS-----------LKD-----LPSDPERLLPEE-DLDVKTSEDQQTAC- 656

  Fly   963 EPGTQQENIGHSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVN 1027
              ||                                    |.|.:..||          :.:|:.
Human   657 --GT------------------------------------IYSQTLSIK----------KLSPII 673

  Fly  1028 ENVGISKQPDEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQSHRSW 1092
            |:   |::              ||:.|....|     :|.||..|.:..                
Human   674 ED---SRE--------------ATHSSGFSGS-----SASVASTSSIKC---------------- 700

  Fly  1093 SQSDLETPPRENFVHPTSNGDQTVLNETLADANKNP----FNVELISSLLE-SIDFSMYIEKLPH 1152
                |:.|.:           ..:.|||..:..::|    :..:|:.||.| |....:.||..| 
Human   701 ----LQIPEK-----------LELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRP- 749

  Fly  1153 CQLVGHVKRLHPNTHLEVHNEKFEVSK--MIGKGAYGSVYVGKHLKSGKKVALKQERPTNYWEFY 1215
                  :.:|.....:|:.||.:.:.:  :|.:. |...:|... .|.:...:|.......|:||
Human   750 ------MPKLEIEKEIELGNEDYCIKREYLICED-YKLFWVAPR-NSAELTVIKVSSQPVPWDFY 806

  Fly  1216 ICLEIHSRLTS--EQMIPSYAHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVV 1278
            |.|::..||..  :.....|.:.|..:|.:.   ||:           |..::.:...:  ||:.
Human   807 INLKLKERLNEDFDHFCSCYQYQDGCIVWHQ---YIN-----------CFTLQDLLQHS--EYIT 855

  Fly  1279 MHLSC----QMLDIVDHLHAMGIIHADIKPDNFLLMK----PICADPNEVSLQLIDFGVSIDMKL 1335
            ..::.    .:|.||:.||...|:|.|:.|...:|..    |...:.|..:|:::||..|:|:::
Human   856 HEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV 920

  Fly  1336 FPDNQTFNYVHHDDLFKCIEMRTGR--------PWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPS 1392
            ..|..|.:.      |:.:::..|:        |  ||:||:|:..:.|:|||..:::|..  ..
Human   921 QLDVFTLSG------FRTVQILEGQKILANCSSP--YQVDLFGIADLAHLLLFKEHLQVFW--DG 975

  Fly  1393 TIWMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLRTQL 1436
            :.|....|:.......:|...|..:||..|..|:..|.:|..::
Human   976 SFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEM 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BubR1NP_477382.1 Mad3_BUB1_I 38..159 CDD:214817 47/120 (39%)
STKc_Bub1_BubR1 1174..1458 CDD:270883 62/283 (22%)
BUB1BNP_001202.5 Mad3_BUB1_I 57..179 CDD:462420 47/121 (39%)
Nuclear localization signal. /evidence=ECO:0000255 111..118 2/6 (33%)
Necessary for interaction with KNL1. /evidence=ECO:0000269|PubMed:17981135 152..185 16/32 (50%)
D-box 224..232 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..393 7/91 (8%)
PTZ00121 <369..>488 CDD:173412 37/280 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..480 7/66 (11%)
STKc_BubR1_vert 750..1045 CDD:270931 66/298 (22%)

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