Sequence 1: | NP_477382.1 | Gene: | BubR1 / 35522 | FlyBaseID: | FBgn0263855 | Length: | 1460 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_004327.1 | Gene: | BUB1 / 699 | HGNCID: | 1148 | Length: | 1085 | Species: | Homo sapiens |
Alignment Length: | 1473 | Identity: | 321/1473 - (21%) |
---|---|---|---|
Similarity: | 519/1473 - (35%) | Gaps: | 502/1473 - (34%) |
- Green bases have known domain annotations that are detailed below.
Fly 41 KQMEEEVRTYKGADPLGAWYTFICWIEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKL 105
Fly 106 FIKFMEKQKDKIEFYQQMYNNGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDL 170
Fly 171 KEAHHHFGYTVGQRMLYSTGEEANAVNQELNERRLALQSLHGRRQQISNSITVGSIRTGAAVKSG 235
Fly 236 LPGVVQVEPSTTTSRRNVGRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVA 300
Fly 301 WNKANAKRHKHGKIFGSNASPDLGFDIHVDEQAMPPITNYERRL----EQPFRFPTNFVAKNRPQ 361
Fly 362 EPWVTPVTIEDEPNASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTG 426
Fly 427 RVIRGIRCYPNFARYSKPQDLDELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAAKWMEK 491
Fly 492 RNVTVHGDFDMEETVCLPGNKMPRRKSFFPSSFRKSIMPRRVS-SVQEEDEKKEDEATLIVKDIP 555
Fly 556 SQVAPKIP----ESPCDQIDEPKIKIFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPF 616
Fly 617 YDGDETCSTQMFNMFIKSQAVSTPKGTQKQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLR 681
Fly 682 KQLSTILETSEHGTQSLATSGTTTKSTITSTSSPGSNAVSKLGSKIEE--NTPGQMRLQRVISAG 744
Fly 745 VSAVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPI 809
Fly 810 ALPENSMDHGSLGAENCFSAPQLPTLEDESD-----------LCGLFGKTPPKTNIFGSPKRNFD 863
Fly 864 PTSQLFKSTQGDRRSFAV-------TGNKLEAAPSISNLQDSFMCDLSFVPETQPEAVAKSGAIQ 921
Fly 922 KFDIFLDDT-------------QPKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGH 973
Fly 974 SHMIASFMKDCTE--IGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNENVGISKQP 1036
Fly 1037 DEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQS------------- 1088
Fly 1089 HRSWSQ-SDLETPPRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLESIDFSMYIEKLPH 1152
Fly 1153 -----CQLVGHVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVYVG-----KHLKSGKKVALKQER 1207
Fly 1208 PTNYWEFYICLEIHSRLTSEQMIPSYAHIDY----ALVGNNSSVYISEFSDYGSLIGVCNKVKSV 1268
Fly 1269 TNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNE----VSLQLIDFGV 1329
Fly 1330 SIDMKLFPDNQTFNYVHHDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTI 1394
Fly 1395 WMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLRTQLK 1437 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
BubR1 | NP_477382.1 | Mad3_BUB1_I | 38..159 | CDD:285506 | 40/117 (34%) |
STKc_Bub1_BubR1 | 1174..1458 | CDD:270883 | 95/277 (34%) | ||
BUB1 | NP_004327.1 | Necessary for kinetochore localization | 1..146 | 49/157 (31%) | |
Mad3_BUB1_I | 5..125 | CDD:214817 | 40/117 (34%) | ||
Nuclear localization signal. /evidence=ECO:0000255 | 58..65 | 2/6 (33%) | |||
Necessary for interaction with KNL1. /evidence=ECO:0000269|PubMed:17981135 | 99..132 | 9/32 (28%) | |||
Necessary for interaction with BUB3 | 229..256 | 10/33 (30%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 305..333 | 12/58 (21%) | |||
Essential for loading of BUBR1, MAD1L1 and MAD2L1 to kinetochores | 458..476 | 6/59 (10%) | |||
KEN box 1 | 535..537 | 0/1 (0%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 538..570 | 7/42 (17%) | |||
KEN box 2 | 625..627 | 0/1 (0%) | |||
STKc_Bub1_vert | 786..1073 | CDD:270930 | 95/277 (34%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C165141958 | |
Domainoid | 1 | 1.000 | 147 | 1.000 | Domainoid score | I4521 |
eggNOG | 1 | 0.900 | - | - | E1_KOG1166 | |
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 277 | 1.000 | Inparanoid score | I2949 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D1411806at2759 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0004065 | |
OrthoInspector | 1 | 1.000 | - | - | otm40587 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_103677 | |
Panther | 1 | 1.100 | - | - | LDO | PTHR14030 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2052 |
SonicParanoid | 1 | 1.000 | - | - | X2819 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
13 | 12.830 |