DRSC/TRiP Functional Genomics Resources

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Protein Alignment BubR1 and BUB1

DIOPT Version :9

Sequence 1:NP_477382.1 Gene:BubR1 / 35522 FlyBaseID:FBgn0263855 Length:1460 Species:Drosophila melanogaster
Sequence 2:NP_004327.1 Gene:BUB1 / 699 HGNCID:1148 Length:1085 Species:Homo sapiens


Alignment Length:1473 Identity:321/1473 - (21%)
Similarity:519/1473 - (35%) Gaps:502/1473 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 KQMEEEVRTYKGADPLGAWYTFICWIEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKL 105
            :.:|..:::|||.||||.|..:|.|:|:::|.  :...|.|:|...:.:|.|.::|..|.|.|..
Human     9 QMLEAHMQSYKGNDPLGEWERYIQWVEENFPE--NKEYLITLLEHLMKEFLDKKKYHNDPRFISY 71

  Fly   106 FIKFMEKQKDKIEFYQQMYNNGIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDL 170
            .:||.|...|..:|::.:||:||||:.:..|||||...:..|.::.|..:.:.|::.:|||.|.|
Human    72 CLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFL 136

  Fly   171 KEAHHHFGYTVGQRMLYSTGEEANAVNQELNERRLALQSLHGRRQQISNSITVGSIRTGAAVKSG 235
            ::          |..|:.|         .|.|..|..|:                 ||...:.: 
Human   137 QQ----------QYRLFQT---------RLTETHLPAQA-----------------RTSEPLHN- 164

  Fly   236 LPGVVQVEPSTTTSRRNVGRNVEVFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVA 300
                |||.....||:.|.|.|:...:  .::|            |.|..:|.|||.:|       
Human   165 ----VQVLNQMITSKSNPGNNMACIS--KNQG------------SELSGVISSACDKE------- 204

  Fly   301 WNKANAKRHKHGKIFGSNASPDLGFDIHVDEQAMPPITNYERRL----EQPFRFPTNFVAKNRPQ 361
                                                 :|.|||:    :..:...::..:|    
Human   205 -------------------------------------SNMERRVITISKSEYSVHSSLASK---- 228

  Fly   362 EPWVTPVTIEDEPNASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTG 426
                  |.:|...    :.|..|.:   |...|||.||.||..:.:.|        :::.|....
Human   229 ------VDVEQVV----MYCKEKLI---RGESEFSFEELRAQKYNQRR--------KHEQWVNED 272

  Fly   427 RVIRGIRCYPNFARYSKPQDLDELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAAKWMEK 491
            |            .|.|.::.:..::          |::..|: :|:.:|.:|..|         
Human   273 R------------HYMKRKEANAFEE----------QLLKQKM-DELHKKLHQVVE--------- 305

  Fly   492 RNVTVHGDFDMEETVCLPGNKMPRRKSFFPSSFRKSIMPRRVS-SVQEEDEKKEDEATLIVKDIP 555
               |.|.|        ||.           |..|..:.|.|:. ||..:.|.:            
Human   306 ---TSHED--------LPA-----------SQERSEVNPARMGPSVGSQQELR------------ 336

  Fly   556 SQVAPKIP----ESPCDQIDEPKIKIFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPF 616
               ||.:|    ::|.:.           ..:||:  |.|.||                      
Human   337 ---APCLPVTYQQTPVNM-----------EKNPRE--APPVVP---------------------- 363

  Fly   617 YDGDETCSTQMFNMFIKSQAVSTPKGTQKQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLR 681
                     .:.|..  |.|:.:|..:|..||                       ||..::.|:.
Human   364 ---------PLANAI--SAALVSPATSQSIAP-----------------------PVPLKAQTVT 394

  Fly   682 KQLSTILETSEHGTQSLATSGTTTKSTITSTSSPGSNAVSKLGSKIEE--NTPGQMRLQRVISAG 744
            ..:..:....         :|...||  |....|.|.|..|.|.:..:  ||..   .....:..
Human   395 DSMFAVASKD---------AGCVNKS--THEFKPQSGAEIKEGCETHKVANTSS---FHTTPNTS 445

  Fly   745 VSAVLSEPEKPGGDNFLRRELWEPNAPSVPMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPI 809
            :..|.:.|.|.           :| :|:|...::|.|                            
Human   446 LGMVQATPSKV-----------QP-SPTVHTKEALGF---------------------------- 470

  Fly   810 ALPENSMDHGSLGAENCFSAPQLPTLEDESD-----------LCGLFGKTPPKTNIFGSPKRNFD 863
                         ..|.|.||.||.:.|:.|           ....|.|....:..:|..|....
Human   471 -------------IMNMFQAPTLPDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISS 522

  Fly   864 PTSQLFKSTQGDRRSFAV-------TGNKLEAAPSISNLQDSFMCDLSFVPETQPEAVAKSGAIQ 921
            .:|.......|::.::.:       ||.:.....|:|.|           |....|.|..:    
Human   523 LSSAFHVFEDGNKENYGLPQPKNKPTGARTFGERSVSRL-----------PSKPKEEVPHA---- 572

  Fly   922 KFDIFLDDT-------------QPKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGH 973
              :.||||:             .||.......|..::|.... .|| .:.|.|.|   .:||:  
Human   573 --EEFLDDSTVWGIRCNKTLAPSPKSPGDFTSAAQLASTPFH-KLP-VESVHILE---DKENV-- 628

  Fly   974 SHMIASFMKDCTE--IGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNENVGISKQP 1036
                  ..|.||:  :.||         :.|:...|...|||           |:.|     |.|
Human   629 ------VAKQCTQATLDSC---------EENMVVPSRDGKFS-----------PIQE-----KSP 662

  Fly  1037 DEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQS------------- 1088
            .:..    ::.|::.::..:..     |.|......|..:..:...||...:             
Human   663 KQAL----SSHMYSASLLRLSQ-----PAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGL 718

  Fly  1089 HRSWSQ-SDLETPPRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLESIDFSMYIEKLPH 1152
            ...|.| |.|.|....||:                  ..||::.:||..||..:  |..:...|:
Human   719 QAEWMQMSSLGTVDAPNFI------------------VGNPWDDKLIFKLLSGL--SKPVSSYPN 763

  Fly  1153 -----CQLVGHVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVYVG-----KHLKSGKKVALKQER 1207
                 |:|    ..:.|.|..::.::...|..::|:||:..||..     ...|:.:|..||.::
Human   764 TFEWQCKL----PAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQK 824

  Fly  1208 PTNYWEFYICLEIHSRLTSEQMIPSYAHIDY----ALVGNNSSVYISEFSDYGSLIGVCNKVKSV 1268
            |.|.|||||..::..||.     ||..|:..    |.:..|.||.:.|...||:|:...|..|:.
Human   825 PANPWEFYIGTQLMERLK-----PSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNT 884

  Fly  1269 TNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNE----VSLQLIDFGV 1329
            ..:.|.:.:|:..:.:||.:::.:|...|||.|||||||:|........:|    ..|.|||.|.
Human   885 PEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQ 949

  Fly  1330 SIDMKLFPDNQTFNYVHHDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTI 1394
            ||||||||....|........|:|:||.:.:||.||:|.:|:.:.::.:|||.||:|  ::....
Human   950 SIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKV--KNEGGE 1012

  Fly  1395 WMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLRTQLK 1437
            ..|:....|.....||...|..:|||.||..:|:|..||.:||
Human  1013 CKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLK 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BubR1NP_477382.1 Mad3_BUB1_I 38..159 CDD:285506 40/117 (34%)
STKc_Bub1_BubR1 1174..1458 CDD:270883 95/277 (34%)
BUB1NP_004327.1 Necessary for kinetochore localization 1..146 49/157 (31%)
Mad3_BUB1_I 5..125 CDD:214817 40/117 (34%)
Nuclear localization signal. /evidence=ECO:0000255 58..65 2/6 (33%)
Necessary for interaction with KNL1. /evidence=ECO:0000269|PubMed:17981135 99..132 9/32 (28%)
Necessary for interaction with BUB3 229..256 10/33 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 305..333 12/58 (21%)
Essential for loading of BUBR1, MAD1L1 and MAD2L1 to kinetochores 458..476 6/59 (10%)
KEN box 1 535..537 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..570 7/42 (17%)
KEN box 2 625..627 0/1 (0%)
STKc_Bub1_vert 786..1073 CDD:270930 95/277 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141958
Domainoid 1 1.000 147 1.000 Domainoid score I4521
eggNOG 1 0.900 - - E1_KOG1166
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 277 1.000 Inparanoid score I2949
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1411806at2759
OrthoFinder 1 1.000 - - FOG0004065
OrthoInspector 1 1.000 - - otm40587
orthoMCL 1 0.900 - - OOG6_103677
Panther 1 1.100 - - LDO PTHR14030
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2052
SonicParanoid 1 1.000 - - X2819
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.830

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