DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BubR1 and bub1ba

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	XP_005160972.1	Gene:	bub1ba / 567931	ZFINID:	ZDB-GENE-041014-120	Length:	722	Species:	Danio rerio

Alignment Length:	717	Identity:	138/717 - (19%)
Similarity:	267/717 - (37%)	Gaps:	176/717 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 RRELWEPNAPSVPMLKSLRFQEDKTE---TIPRPL-ACFQEDKTETLPQMPIALPENSMDHGSLG 822
            :|:|.:.::.:.|   ..||.|||.|   :|.||. :|  |...:|:...|:.:....
Zfish   103 QRKLHQRSSTAAP---QQRFPEDKREASSSIQRPTGSC--ESAADTVKSAPLVIYSEQ------- 155

  Fly   823 AENC-FSAPQLPTLEDESDLCGLFGKTPPKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVT-GNK 885
            .|.| .|:....:.||:.:..|...|.          ::...|.:...:|||.::.|.:|: .::
Zfish   156 EEGCAVSSSSSVSREDDMNQSGSDAKL----------QKTAKPFTIYDESTQTNKISSSVSREDE 210

  Fly   886 LEAAPSISNLQDSFMCDLSFVPETQPEAVA-------------------KSGAIQKFDIFLDDTQ 931
            :..:.|.:.||.:......:...:|...::                   |:|..:.|.:|.|:.|
Zfish   211 INQSGSDAKLQKTAKTFTIYDENSQTNKISTSVSREDDMNQSGSDAKLQKTGTGKPFTMFEDNAQ 275

  Fly   932 PKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGTQQENIGHSHMIASFMKDCTEIGSCPSQMPA 996
            ...|.|       |:......||   .:::|.|.::.|.:             |:..:..|:...
Zfish   276 TSKTSS-------STNRKSLKLP---TLSLKAPKSKAELV-------------TDKDASISRSEE 317

  Fly   997 SVV-----KTNISSTSNKIKFSNDSMSESSRKAPVNENVGISKQPDEFFELNAATEMFATNISMI 1056
            :::     ||...|.::..:|:..:...||..|.|:.    .|.|:               ..::
Zfish   318 AIINGHRNKTLCRSPNDTCEFARAAQLASSPFAGVDR----QKTPE---------------TGLM 363

  Fly  1057 KNSTLLIP-NAKVAEASELSIYYKTTPLTPKQSHRSWSQSDLETPPRENFVHPTSNGDQTVLNET 1120
            :|.:...| :.|.|..:|.....|.:|:.  :..:.|..|.....|.:......|:.........
Zfish   364 ENLSPADPESTKAANINETPEEKKLSPIL--EISQEWGGSTFCQDPTKRLNDAESSRSAERPETE 426

  Fly  1121 LADANK--NPFNVELISSLLESIDFSMYIEKLPHCQLVGHVKR-LHPNTHLEVH---NEKFEVSK 1179
            |.:.:|  :..::.:.|.:.:..|    :..||:.    |.|. |.|:|..::|   .:.|..||
Zfish   427 LENVSKWQDVCSLHVRSRIFDQSD----VTSLPNF----HRKAGLLPDTSDDLHLDGEQLFYCSK 483

  Fly  1180 MIGKGAYGSVYVGKHLKSG-KKVALKQERPTNYWEFYICLEIHSRLTSEQM---IPSYAHIDYAL 1240
            :      |||.......|| ..|.||.:|.:..|:|:|..::.||...::.   :....|
Zfish   484 L------GSVKDFSLYSSGTAAVLLKTDRSSVPWDFFIISQLRSRGCCDEQGCDVQISCH----- 537

  Fly  1241 VGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHLSC----QMLDIVDHLHAMGIIHAD 1301
            :..|.||.:.......:|..:           :.|.:..|.:|    .:|::|...|:..::|..
Zfish   538 MFENGSVTLWRIPHGDTLQDL-----------LCEPLARHDACLLVILLLELVRCFHSCRLLHGG 591

  Fly  1302 IKPDNFLLMKPICADPNEVSLQLIDFGVSIDMKL---------FPDNQTFNYVHHDDLFKCIEMR 1357
            :||::....        ...|..:||..|:|:.|         .|..|.|           |:..
Zfish   592 LKPESLYFY--------HSGLTALDFSDSVDLHLQTDVTEAQDLPSAQQF-----------IQQG 637

  Fly  1358 TGRPWT--YQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIW-MPKTNVPRYF--QRTMWENIFRTL 1417
            ...|..  ||:||..:..:.|.|||...::|  :...::| :.:.:..::.  ...:|...|..:
Zfish   638 LLAPSASPYQVDLISVAEITHRLLFNAPLQV--KLVDSVWRLDEDSASQHGCPVEPLWREFFHMI 700

  Fly  1418 LN 1419
            ||
Zfish   701 LN 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883	56/268 (21%)
bub1ba	XP_005160972.1	PKc_like	499..714	CDD:304357	48/241 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830