DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BubR1 and bub1bb

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	XP_695384.3	Gene:	bub1bb / 567006	ZFINID:	ZDB-GENE-030829-51	Length:	427	Species:	Danio rerio

Alignment Length:	444	Identity:	122/444 - (27%)
Similarity:	204/444 - (45%)	Gaps:	48/444 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDNAKENIQPLASGRNVSLLQASLSQDSTHGQELLAQRKQ-MEEEVRTYKGADPLGAWYTFICW 65
            :::.:|||||||..||:||.|..:|.|........|..:|| .|.|:|.|.|.|||..|..:|.|
Zfish     7 EWEYSKENIQPLRQGRSVSALHQALCQQQEGNHTALNLKKQEFESELRLYDGDDPLDVWVRYIKW 71

  Fly    66 IEQSYPAGGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGT 130
            .:|:||.||..|.:..:|.:.:.:|..:::|..|.|.::|:|:|.|...|.::.::.|...||||
Zfish    72 AKQTYPQGGKESNISVLLERAVMRFTAEQKYHNDVRYVELWIQFAESSSDPMDVFRYMQAQGIGT 136

  Fly   131 MLADFYIAWAYSYDLSGNMRKADEIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANA 195
            |.|.|||||:..::..|||:.||.:|:.|::|.|||.:.|...|......|.::|:.|..|:...
Zfish   137 MQAVFYIAWSEEHEKRGNMKMADSVFQDGVKCGAEPSDKLHAFHRALQARVCRQMMTSMTEQHRN 201

  Fly   196 VNQELNE--RRLALQSLHGRRQQISNSITVGSIRTGAAVKSGLPGVVQVEPSTTTSRRNVGRNVE 258
            .:.|.:|  :|.:|..|..:.:: ..::.:..::.......||.....:.|...:       .:.
Zfish   202 DDDEDDEEPQRASLAELKAKGKK-KATVPINRVKASVGYARGLQFKQPLGPKQNS-------RLM 258

  Fly   259 VFNDENSEGNIPISNSETEVKSSLRSIIDSACSQENIKEPVAWNKANAKRHKHGKIFGSNASPDL 323
            :| |||...:.|     .|.:..:.:...:|.::||.::...|:...........:..:...|..
Zfish   259 IF-DENKAESEP-----QEPRFEVWTAPPAARAKENQQKVEKWSNVKLPLKSRSGLSVAVPPPKP 317

  Fly   324 GFDIHVDEQAMPPITNYERRLEQPFRF---PTNFVAKNRPQEPWVTPV---------TIED-EPN 375
            .|...|:|...||...       |.:.   ..:.::..:|.....||:         |:|| |..
Zfish   318 SFQPFVEEDDQPPAVT-------PCKINPAVNSVLSARKPSRLEQTPLKKLQEKQMQTLEDGESR 375

  Fly   376 ASGLPCYNKCLLYPRPNIEFSPEEYRAYSFLK-H--RNPQHPF-----IHRNDD 421
            ...:.|  :.|||.... ||..||.||..:|: |  .|.:.|.     :|.|.|
Zfish   376 EQSMYC--RDLLYSGAT-EFCFEELRAQRYLQTHTIHNLKTPHTSTHCLHTNTD 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	47/121 (39%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883
bub1bb	XP_695384.3	Mad3_BUB1_I	45..165	CDD:285506	47/119 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574862
Domainoid	1	1.000	88	1.000	Domainoid score	I7929
eggNOG	1	0.900	-	-		E1_KOG1166
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1411806at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2052
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.780