DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BubR1 and Bub1

DIOPT Version :9

Sequence 1:	NP_477382.1	Gene:	BubR1 / 35522	FlyBaseID:	FBgn0263855	Length:	1460	Species:	Drosophila melanogaster
Sequence 2:	NP_001285621.1	Gene:	Bub1 / 33758	FlyBaseID:	FBgn0031696	Length:	1099	Species:	Drosophila melanogaster

Alignment Length:	1479	Identity:	339/1479 - (22%)
Similarity:	543/1479 - (36%)	Gaps:	465/1479 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SQDSTHGQELLAQRKQMEEEVRTYKGADPLGAWYTFICWIE---QSYPAGGSGSGLQTVLHQCLT 88
            |.|..||  .|..::..|..:..|:|.|||..||.:|||.|   ||.|.    ...:..|.:|||
  Fly    29 SPDEMHG--FLNDKQAWEHAISLYQGPDPLDHWYNYICWYENHAQSDPE----LKYRETLERCLT 87

  Fly    89 KFEDDERYRQDKRLIKLFIKFMEKQKDKIEFYQQMYNNGIGTMLADFYIAWAYSYDLSGNMRKAD 153
            .:|.::.||||.||::|::|::..|.|.:.|||.::..|.|..:|.|||.||..|:.....:.|:
  Fly    88 VYEHNDYYRQDVRLVRLWLKYIAMQTDPLHFYQVLFQRGTGRQVAAFYIGWAAYYESREEYKDAE 152

  Fly   154 EIFRLGLECRAEPLEDLKEAHHHFGYTVGQRMLYSTGEEANAVNQELNER---RLALQSL-HGRR 214
            .:|.|..:.:|:...:|:.||..|.|.   |.|:...::.....|:.:::   :.|||.| :..:
  Fly   153 AVFNLAFQEKAQSTSELQHAHTKFAYA---RSLFYQRQQQQQQQQQQHQQHPPQDALQQLTNYAQ 214

  Fly   215 QQISNSITVGSIRT----------------------GAAVKSGLPGVVQVEPSTTTSRRNVGRNV 257
            ||:..|......:.                      ..|.:..||...||...|....|   ...
  Fly   215 QQMPQSYNQHRPQPYQQNVYQQYHPQAQAHQAPQPHQPAPQQQLPPEQQVPYQTHYQER---PRY 276

  Fly   258 EVFNDENSEGNIPISNSETEVKSSLRSIIDS--ACSQENIKEP--VAWNKANAKRHKHGKIFGSN 318
            |......|...||  .|:.:.:|....:.:|  |.:|::...|  ....:.:|::.:..:....|
  Fly   277 EPHPATQSPTAIP--PSQVQQQSHYAPVAESHYAPAQQSQLPPQQTTVPQLHAQQPQQQQNGNGN 339

  Fly   319 ASPDLGFDIHVDEQAMPPITNYERRLEQPFRFPTNFVAKNR-PQEPWVTPVTIEDEPNASGLPCY 382
            ..|          |..||:||....|    |.|.||.|..| ..|.|...:|:|:..:.|.:..|
  Fly   340 PPP----------QQSPPVTNEVAGL----RLPRNFHAYGRNNHETWKPALTLEEPDDPSRVCHY 390

  Fly   383 NKCLLY-PRPNIEFSPEEYRAYSFLKHRNPQHPFIHRNDDWWGTGRVIRGIRCYPNFARYSKPQD 446
            .|.|:| |...:|:||||..|..|                                      .|.
  Fly   391 AKQLVYPPGAGVEYSPEEILARKF--------------------------------------KQL 417

  Fly   447 LDELDKFWKPPLVPGLQVVFDKIYNEVEQKEYQPEELLAAKWMEKRNVTVHGDFDMEETVCLPGN 511
            :|:..|..:||              |.||:                  |::..::.|
  Fly   418 MDQKAKPSEPP--------------EQEQQ------------------TLYDSYETE-------- 442

  Fly   512 KMPRRKSFFPSSFRKSIMPRRVSSVQEEDEKKEDEATLIVKDIPSQVAPKIPESPCDQIDEPKIK 576
                 ||::.::...::..:..||.| |:..:|||                 ::..::.:|.
  Fly   443 -----KSYYMTAVDGALYGQNTSSGQ-ENTGEEDE-----------------DNDAEEGEEE--- 481

  Fly   577 IFEDSGSPRDNFAVPAVPVPKIEIYEDSEEPQPTPKTRPFYDGDETCSTQMFNMFIKSQAVSTPK 641
              ||.|...:.              :||:|.:         :.||
  Fly   482 --EDGGEENEE--------------DDSDEEE---------EDDE-------------------- 501

  Fly   642 GTQKQAPSRQFGTVLKELPLPEEAAHSVESPVETRSPTLRKQLSTILETSEHGTQSLATSGTTTK 706
                                 ||..||  .|.                     |..:..|..||.
  Fly   502 ---------------------EEEEHS--GPY---------------------TNGVQFSAQTTF 522

  Fly   707 STITSTSSPGSNAVSKLGSKIEENTPGQMRLQRVISAGVSAVLSEPEKPGGDNFLRRELWEPNAP 771
            .                    :||...:::.::..|:..||...|       |..:::..:
  Fly   523 E--------------------QENRSIKIKFRKEPSSTYSAYTIE-------NVYQQQQQQ---- 556

  Fly   772 SVPMLKSLRFQEDKTETIPRPLACFQEDKTETLPQMPIALPENSMDHGSLGAENCFSAPQLPTLE 836
                      |:::.:.|.:|.........:..|..||  |.....:||
  Fly   557 ----------QQEQHQIIHQPPQAVHHPSPDPAPASPI--PIQRQRNGS---------------- 593

  Fly   837 DESDLCGLFGKTPPKTNIFGSPKRNFDPTSQLFKSTQGDRRSFAVTGNKLEAAPSISNLQDSFMC 901
                                  ..:|.|                                  :|.
  Fly   594 ----------------------HHHFHP----------------------------------YML 602

  Fly   902 DLSFVPETQPEAVAKSGAIQKFDIFLDDTQPKLTKSKPVALMVSSFDLDCTLPETQQVAIKEPGT 966
            ..:..|:::.....::....|...|..|.......:..||.:.||           .|....|||
  Fly   603 GQTSTPKSEANGYRRARTKVKRSKFQPDLCSNSNSASSVADVASS-----------SVLAGAPGT 656

  Fly   967 QQENIGHSHMIASFMKDCTEIGSCPSQMPASVVKTNISSTSNKIKFSNDSMSESSRKAPVNENVG 1031
            ..:|...|      ....|.:.:..|.:..:|.:.|...|           |:.....|||:.:.
  Fly   657 FNDNANFS------FSSATALDNSNSSLALAVDRLNFRDT-----------SQQQILHPVNKTLQ 704

  Fly  1032 ISKQPDEFFELNAATEMFATNISMIKNSTLLIPNAKVAEASELSIYYKTTPLTPKQSHRSWSQSD 1096
            |....:.....|..|...|...:..:||                 |:.|             |.|
  Fly   705 IHNNNNNTSNNNNGTSTMADFSTFQENS-----------------YFAT-------------QHD 739

  Fly  1097 LETPPRENFVHPTSNGDQTVLNETLADANKNPFNVELISSLLESIDF--------SMYIEKLPHC 1153
            .|...|.     .|...:|:......:| .:|||.||..:.|..:||        |..|.:.| .
  Fly   740 TEAQERR-----LSKAVETIARHMDKEA-IDPFNSELCRAFLAKLDFPGNHDAHASYKIVQTP-L 797

  Fly  1154 QLVGHVKRLHPNTHLEVHNEKFEVSKMIGKGAYGSVYVGKHLKSGKKVALKQERPTNYWEFYICL 1218
            ..:.:.:.|:     .:....|.:.|.:|:|:|||||.....::|..||||.::|.|.||.|||.
  Fly   798 PKISNTRTLN-----VLEGVTFSIDKEVGRGSYGSVYKATDSRTGNVVALKYQKPPNTWEIYICD 857

  Fly  1219 EIHSRLTSEQMIPSYAHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHLSC 1283
            ::..|:...:::|....|..|::..|:|:..:|||.:|||:.:.||::..|.:.|.|.:|||.|.
  Fly   858 QVLKRIKEPEVLPGVMDISTAIIAPNASLIATEFSPFGSLLDINNKIRQATTKVMHESLVMHFSA 922

  Fly  1284 QMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNEVSLQLIDFGVSIDMKLFPDNQ--TFNYVH 1346
            |:.:||||||...||||||||||||||:....|....||:|||||.:|||.||||.:  .|..|.
  Fly   923 QICNIVDHLHRQHIIHADIKPDNFLLMRVPNVDSPLPSLRLIDFGCAIDMTLFPDGEKTKFRKVV 987

  Fly  1347 HDDLFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIWMPKTNVPRYFQRTMWE 1411
            ..|.|.||||:.||.|:|:.||:.:.:.:||:|||.||:..::..|  |..:..:|||.::.:|.
  Fly   988 QTDGFTCIEMQEGRSWSYETDLFCIAATVHVMLFGDYMQPQKKGSS--WEIRQKLPRYLKKHVWT 1050

  Fly  1412 NIFRTLLNIRDCRTMPNLQQLRTQLKCALAEKEKYVAEAISKFNTILQK 1460
            ..|..|||:: ...:|.|.::|     .:.|:|.|      :.::.|||
  Fly  1051 KFFGDLLNMQ-ADKLPALHEMR-----LIFEEEAY------RMDSELQK 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BubR1	NP_477382.1	Mad3_BUB1_I	38..159	CDD:285506	44/123 (36%)
BubR1	NP_477382.1	STKc_Bub1_BubR1	1174..1458	CDD:270883	115/285 (40%)
Bub1	NP_001285621.1	Mad3_BUB1_I	38..158	CDD:214817	44/123 (36%)
Bub1	NP_001285621.1	STKc_Bub1_BubR1	813..1096	CDD:270883	118/289 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442662
Domainoid	1	1.000	113	1.000	Domainoid score	I2040
eggNOG	1	0.900	-	-		E1_KOG1166
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I1216
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1411806at2759
OrthoFinder	1	1.000	-	-		FOG0004065
OrthoInspector	1	1.000	-	-		otm26507
orthoMCL	1	0.900	-	-		OOG6_103677
Panther	1	1.100	-	-	P	PTHR14030
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2819
	10	9.890